Stem cells and regenerative medicine

Tatullo, Marco; Gargiulo, Isacco Ciro; Dipalma, Gianna; Ballini, Andrea; Inchingolo, Angelo Michele; Paduanelli, Gregorio; Nguyen, Cao đẳng Kinh; Inchingolo, Alessio Danilo; Makeeva, Irina; Scacco, Salvatore; Nuzzolese, Manuel; Vito, Danila De; Inchingolo, Francesco

doi:10.1016/b978-0-12-813762-8.00017-7

Cited by 14 publications

(7 citation statements)

References 86 publications

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“…Stem cells are classified into two categories: embryonic (totipotent and pluripotent) and nonembryonic (multipotent, oligopotent, and unipotent), based on where they are derived [ 185 ]. Self-renewing pluripotent stem cells express transcription factors for the blastula formation that generate the three germ layers: ectoderm, mesoderm, and endotherm [ 186 , 187 , 188 , 189 ]. The ectoderm gives rise to the nervous system, the mesoderm gives rise to connective and muscular tissue, and the endoderm gives rise to organ systems throughout the body [ 190 ].…”

Section: Neurotrophic Support In Neuropathy Treatmentmentioning

confidence: 99%

“…The ectoderm gives rise to the nervous system, the mesoderm gives rise to connective and muscular tissue, and the endoderm gives rise to organ systems throughout the body [ 190 ]. Multipotent stem cells, commonly derived from bone marrow, adipose tissue, or dental pulp, experience differentiation into several cell types within one designated germ line [ 186 , 187 , 188 , 191 ]. Once within a specific lineage, differentiation is flexible [ 185 ].…”

Section: Neurotrophic Support In Neuropathy Treatmentmentioning

confidence: 99%

“…Due to increased plasticity, self-renewal, and proliferative properties, totipotent, pluripotent, and multipotent stem cells are most advantageous in tissue engineering [ 188 ]. However, there are limitations associated, primarily moral objections when harvesting embryonic stem cells and uncontrolled teratoma formation and immunorejection, once clinically applied [ 187 , 188 , 192 ].…”

Section: Neurotrophic Support In Neuropathy Treatmentmentioning

confidence: 99%

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Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications

Berry,

Ene,

Nathani

et al. 2024

Biomedicines

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The peripheral nervous system undergoes sufficient stress when affected by diabetic conditions, chemotherapeutic drugs, and personal injury. Consequently, peripheral neuropathy arises as the most common complication, leading to debilitating symptoms that significantly alter the quality and way of life. The resulting chronic pain requires a treatment approach that does not simply mask the accompanying symptoms but provides the necessary external environment and neurotrophic factors that will effectively facilitate nerve regeneration. Under normal conditions, the peripheral nervous system self-regenerates very slowly. The rate of progression is further hindered by the development of fibrosis and scar tissue formation, which does not allow sufficient neurite outgrowth to the target site. By incorporating scaffolding supplemented with secretome derived from human mesenchymal stem cells, it is hypothesized that neurotrophic factors and cellular signaling can facilitate the optimal microenvironment for nerve reinnervation. However, conventional methods of secretory vesicle production are low yield, thus requiring improved methods to enhance paracrine secretions. This report highlights the state-of-the-art methods of neuropathy treatment as well as methods to optimize the clinical application of stem cells and derived secretory vesicles for nerve regeneration.

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Section: Neurotrophic Support In Neuropathy Treatmentmentioning

confidence: 99%

Section: Neurotrophic Support In Neuropathy Treatmentmentioning

confidence: 99%

Section: Neurotrophic Support In Neuropathy Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications

Berry,

Ene,

Nathani

et al. 2024

Biomedicines

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“…For doctors, orthopedists and dentists, the use of pluripotent and multipotent stem cells, such as MSCs, constitute a superior quality method that exponentially improves the body’s regenerative capacity and ability. In fact, stem cells (SCs) are generally able not only to differentiate into new tissue but also coordinate, modulate and manage the entire chain of events of both repair and regenerative responses—just think of their role on M1 pro-inflammatory macrophages [ 291 , 292 , 293 , 294 , 295 , 296 ]. The M1s under pressure from MSCs trigger the recruitment of interleukins and pro-inflammatory cytokines involved in the first phase of the repair process, such as IL-1β, IL-2, IL-6, IL-17, TNFα and IFNγ, while M2 initiate recruitment in the second phase of anti-inflammatory interleukins, such as IL-10, IL-4 and IL-13, prostaglandin E2, oncostatin and bone morphogenetic protein 2 (BMP-2).…”

Section: Stem Cells Therapies For Regenerative and Translational Medi...mentioning

confidence: 99%

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

et al. 2022

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Background: For decades, regenerative medicine and dentistry have been improved with new therapies and innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review the recent innovations in the field of bone regeneration with a focus on the healing potentials and clinical protocols of bone substitutes combined with engineered constructs, growth factors and photobiomodulation applications. Methods: A Boolean systematic search was conducted by PubMed/Medline, PubMed/Central, Web of Science and Google scholar databases according to the PRISMA guidelines. Results: After the initial screening, a total of 304 papers were considered eligible for the qualitative synthesis. The articles included were categorized according to the main topics: alloplastic bone substitutes, autologous teeth derived substitutes, xenografts, platelet-derived concentrates, laser therapy, microbiota and bone metabolism and mesenchymal cells construct. Conclusions: The effectiveness of the present investigation showed that the use of biocompatible and bio-resorbable bone substitutes are related to the high-predictability of the bone regeneration protocols, while the oral microbiota and systemic health of the patient produce a clinical advantage for the long-term success of the regeneration procedures and implant-supported restorations. The use of growth factors is able to reduce the co-morbidity of the regenerative procedure ameliorating the post-operative healing phase. The LLLT is an adjuvant protocol to improve the soft and hard tissues response for bone regeneration treatment protocols.

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“…HSCs can further differentiate to form oligopotent stem cells/progenitors with limited differentiation ability to form cells for specific lineage, such as myeloid and lymphoid ( Ebihara et al, 1997 ; Coulombel, 2004 ). Finally, fully specialised cells that can reproduce to generate more tissue-specific cells are defined as unipotent stem cells such as skin, cornea, muscle, pancreas, etcetera ( Tatullo et al, 2019 ).…”

Section: An Overview Of Cells and Stem Cellsmentioning

confidence: 99%

Future stem cell analysis: progress and challenges towards state-of-the art approaches in automated cells analysis

Zamani

Zaki

Hamid

et al. 2022

PeerJ

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Background and Aims A microscopic image has been used in cell analysis for cell type identification and classification, cell counting and cell size measurement. Most previous research works are tedious, including detailed understanding and time-consuming. The scientists and researchers are seeking modern and automatic cell analysis approaches in line with the current in-demand technology. Objectives This article provides a brief overview of a general cell and specific stem cell analysis approaches from the history of cell discovery up to the state-of-the-art approaches. Methodology A content description of the literature study has been surveyed from specific manuscript databases using three review methods: manuscript identification, screening, and inclusion. This review methodology is based on Prism guidelines in searching for originality and novelty in studies concerning cell analysis. Results By analysing generic cell and specific stem cell analysis approaches, current technology offers tremendous potential in assisting medical experts in performing cell analysis using a method that is less laborious, cost-effective, and reduces error rates. Conclusion This review uncovers potential research gaps concerning generic cell and specific stem cell analysis. Thus, it could be a reference for developing automated cells analysis approaches using current technology such as artificial intelligence and deep learning.

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Stem cells and regenerative medicine

Cited by 14 publications

References 86 publications

Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications

Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

Future stem cell analysis: progress and challenges towards state-of-the art approaches in automated cells analysis

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