Stem cell therapeutics—reality versus hype and hope

Zech, Nicolas H.; Preisegger, Karl‐Heinz; Hollands, Peter

doi:10.1007/s10815-010-9520-6

Cited by 4 publications

(2 citation statements)

References 32 publications

(28 reference statements)

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“…Stem cells are undifferentiated cells characterized by their ability to self‐renew and to differentiate into multiple lineages [Zech et al, 2011]. In contrast to embryonic stem cells (ESCs), adult stem cells are immune‐compatible and there are no ethical issues related to their use [Brignier and Gewirtz, 2010].…”

mentioning

confidence: 99%

Human adipose CD34⁺CD90⁺ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues

Ferraro

Francesco

Nicoletti

et al. 2013

J of Cellular Biochemistry

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Stem cell based therapies for the repair and regeneration of various tissues are of great interest for a high number of diseases. Adult stem cells, instead, are more available, abundant and harvested with minimally invasive procedures. In particular, mesenchymal stem cells (MSCs) are multi-potent progenitors, able to differentiate into bone, cartilage, and adipose tissues. Human adult adipose tissue seems to be the most abundant source of MSCs and, due to its easy accessibility; it is able to give a considerable amount of stem cells. In this study, we selected MSCs co-expressing CD34 and CD90 from adipose tissue. This stem cell population displayed higher proliferative capacity than CD34(-) CD90(-) cells and was able to differentiate in vitro into adipocytes (PPARγ(+) and adiponectin(+)) and endothelial cells (CD31(+) VEGF(+) Flk1(+)). In addition, in methylcellulose without VEGF, it formed a vascular network. The aim of this study was to investigate differentiation potential of human adipose CD34(+) /CD90(+) stem cells loaded onto commercial collagen sponges already used in clinical practice (Gingistat) both in vitro and in vivo. The results of this study clearly demonstrate that human adult adipose and loose connective tissues can be obtained in vivo, highlighting that CD34(+) /CD90 ASCs are extremely useful for regenerative medicine.

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confidence: 99%

Human adipose CD34⁺CD90⁺ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues

Ferraro

Francesco

Nicoletti

et al. 2013

J of Cellular Biochemistry

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“…Engineering bone tissue was only made possible with the discovery and utilization of stem cells that are capable of self-renewal and differentiation into a bevy of lineages. 6 The implementation of stem cells for the purpose of bone regeneration potentially eliminates the aforementioned problems associated with autologous and allogenic grafts. 5 Because of their high differentiation potential and low morbidity during harvesting, bone marrow stem cells (BMSCs) have been considered the gold standard in bone tissue engineering.…”

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confidence: 99%

Review of the Pathways Involved in the Osteogenic Differentiation of Adipose-Derived Stem Cells

Asserson

Orbay²,

Sahar³

2019

Journal of Craniofacial Surgery

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Grafts and prosthetic materials used for the repair of bone defects are often accompanied by comorbidity and rejection. Therefore, there is an immense need for novel approaches to combating the issues surrounding such defects. Because of their accessibility, substantial proportion, and osteogenic differentiation potential, adipose-derived stem cells (ASCs) make for an ideal source of bone tissue in regenerative medicine. However, efficient induction of ASCs toward an osteoblastic lineage in vivo is met with challenges, and many signaling pathways must come together to secure osteoblastogenesis. Among them are bone morphogenic protein, wingless-related integration site protein, Notch, Hedgehog, fibroblast growth factor, vascular endothelial growth factor, and extracellular regulated-signal kinase. The goal of this literature review is to conglomerate the present research on these pathways to formulate a better understanding of how ASCs are most effectively transformed into bone in the context of tissue engineering.

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Clinical Applications of Stem Cells in Women’s Reproductive Health

Mousa

Shazly

Nassr

2016

Stem Cell Biology and Regenerative Medicine

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Stem cell therapeutics—reality versus hype and hope

Cited by 4 publications

References 32 publications

Human adipose CD34⁺CD90⁺ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues

Human adipose CD34⁺CD90⁺ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues

Review of the Pathways Involved in the Osteogenic Differentiation of Adipose-Derived Stem Cells

Clinical Applications of Stem Cells in Women’s Reproductive Health

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Stem cell therapeutics—reality versus hype and hope

Cited by 4 publications

References 32 publications

Human adipose CD34+CD90+ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues

Human adipose CD34+CD90+ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues

Review of the Pathways Involved in the Osteogenic Differentiation of Adipose-Derived Stem Cells

Clinical Applications of Stem Cells in Women’s Reproductive Health

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Product

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Human adipose CD34⁺CD90⁺ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues

Human adipose CD34⁺CD90⁺ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues