volume 25, issue 7, P949-955 2012
DOI: 10.1038/modpathol.2012.37
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Gulnur Guler, Serdar Balci, Stefan Costinean, Cigdem Himmetoglu Ussakli, Cigdem Irkkan, Dinc Suren, Ebru Sari, Kadri Altundag, Yavuz Ozisik, Susie Jones, Jason Bacher, Charles L Shapiro, Kay Huebner

Abstract: It has been reported previously that: 1) normal breast epithelial cells that are CD24-/44+ express higher levels of stem/progenitor cell associated genes; 2) cancer cells that have undergone epithelial to mesenchymal transition display CD24-/44+ cell surface expression, a marker for breast cancer stem cells; 3) loss of E-cadherin is a preliminary step in epithelial to mesenchymal transition; and 4) vimentin is a marker of mesenchymal phenotype.We hypothesized that stem cell subpopulations would be more frequen…

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