Stem cell quiescence and its clinical relevance

Luo, Meng; Li, Jin-Fan; Yang, Qi; Zhang, Kun; Wang, Zhanwei; Zheng, Shu; Zhou, Jiaojiao

doi:10.4252/wjsc.v12.i11.1307

Cited by 27 publications

(18 citation statements)

References 147 publications

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“…These findings support a speculation that higher stemness features in CCSCs are associated with treatment failure. In addition to driving cells to an undifferentiated stage with high proliferative capacity, stemness can poise cells to enter a senescence/quiescent state to escape death and reach a state of reversible cell cycle arrest (60,61).…”

Section: Discussionmentioning

confidence: 99%

Cervical Cancer Stem-Like Cell Transcriptome Profiles Predict Response to Chemoradiotherapy

et al. 2021

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Cervical cancer (CC) represents a major global health issue, particularly impacting women from resource constrained regions worldwide. Treatment refractoriness to standard chemoradiotheraphy has identified cancer stem cells as critical coordinators behind the biological mechanisms of resistance, contributing to CC recurrence. In this work, we evaluated differential gene expression in cervical cancer stem-like cells (CCSC) as biomarkers related to intrinsic chemoradioresistance in CC. A total of 31 patients with locally advanced CC and referred to Mário Penna Institute (Belo Horizonte, Brazil) from August 2017 to May 2018 were recruited for the study. Fluorescence-activated cell sorting was used to enrich CD34+/CD45- CCSC from tumor biopsies. Transcriptome was performed using ultra-low input RNA sequencing and differentially expressed genes (DEGs) using Log2 fold differences and adjusted p-value < 0.05 were determined. The analysis returned 1050 DEGs when comparing the Non-Responder (NR) (n=10) and Responder (R) (n=21) groups to chemoradiotherapy. These included a wide-ranging pattern of underexpressed coding genes in the NR vs. R patients and a panel of lncRNAs and miRNAs with implications for CC tumorigenesis. A panel of biomarkers was selected using the rank-based AUC (Area Under the ROC Curve) and pAUC (partial AUC) measurements for diagnostic sensitivity and specificity. Genes overlapping between the 21 highest AUC and pAUC loci revealed seven genes with a strong capacity for identifying NR vs. R patients (ILF2, RBM22P2, ACO16722.1, AL360175.1 and AC092354.1), of which four also returned significant survival Hazard Ratios. This study identifies DEG signatures that provide potential biomarkers in CC prognosis and treatment outcome, as well as identifies potential alternative targets for cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Cervical Cancer Stem-Like Cell Transcriptome Profiles Predict Response to Chemoradiotherapy

et al. 2021

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“…For instance, leukemia inhibitory factor (LIF), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HMOX-1) were secreted from pericytes and worked as inhibitory cytokines during inflammation [ 45 , 46 ]. Moreover, pericytes induce stem-cell quiescence and protect them from exhaustion and senescence by releasing quiescence-inducing factors such as bone morphogenetic protein-4, 6, 7 (Bmp-4, 6, 7), which preserves stem-cell regenerative capabilities [ 47 , 48 ].…”

Section: Characteristics Of Pericytesmentioning

confidence: 99%

Emerging Role of Pericytes and Their Secretome in the Heart

Cantrell

Zeng

et al. 2021

Cells

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Pericytes, as mural cells covering microvascular capillaries, play an essential role in vascular remodeling and maintaining vascular functions and blood flow. Pericytes are crucial participants in the physiological and pathological processes of cardiovascular disease. They actively interact with endothelial cells, vascular smooth muscle cells (VSMCs), fibroblasts, and other cells via the mechanisms involved in the secretome. The secretome of pericytes, along with diverse molecules including proinflammatory cytokines, angiogenic growth factors, and the extracellular matrix (ECM), has great impacts on the formation, stabilization, and remodeling of vasculature, as well as on regenerative processes. Emerging evidence also indicates that pericytes work as mesenchymal cells or progenitor cells in cardiovascular regeneration. Their capacity for differentiation also contributes to vascular remodeling in different ways. Previous studies primarily focused on the roles of pericytes in organs such as the brain, retina, lung, and kidney; very few studies have focused on pericytes in the heart. In this review, following a brief introduction of the origin and fundamental characteristics of pericytes, we focus on pericyte functions and mechanisms with respect to heart disease, ending with the promising use of cardiac pericytes in the treatment of ischemic heart failure.

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“…Dormancy-competent CSCs are the subset of cancer stem cells that can plastically switch between dormancy and proliferation [ 16 ]. The authors propose that dormancy-competent cancer stem cells may be present at the initial phases of tumor development but as genetic alterations accumulate, they progressively lose their dormant potential so that more advanced tumors mostly contain highly mutated dormancy-incompetent CSCs, which fuel uncontrolled proliferation [ 16 , 17 ].…”

Section: Cellular and Tumor Dormancy: Terminologymentioning

confidence: 99%

Tumor Dormancy: Implications for Invasion and Metastasis

Gomatou

Syrigos

Vathiotis

et al. 2021

IJMS

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Tumor dormancy refers to a critical stage of cancer development when tumor cells are present, but cancer does not progress. It includes both the concept of cellular dormancy, indicating the reversible switch of a cancer cell to a quiescent state, and that of tumor mass dormancy, indicating the presence of neoplastic masses that have reached cell population equilibrium via balanced growth/apoptosis rates. Tumor dormancy provides the conceptual framework, potentially explaining a major challenge in clinical oncology, tumor recurrence, which may occur years after cancer diagnosis. The mechanisms by which tumors are kept dormant, and what triggers their reawakening, are fundamental questions in cancer biology. It seems that a plethora of intracellular pathways and extracellular factors are involved in this process, rewiring the cells to plastically alter their metabolic and proliferative status. This phenomenon is highly dynamic in space and time. Mechanistic insights into both cellular and tumor dormancy have provided the rationale for targeting this otherwise stable period of cancer development, in order to prevent recurrence and maximize therapeutic benefit.

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Stem cell quiescence and its clinical relevance

Cited by 27 publications

References 147 publications

Cervical Cancer Stem-Like Cell Transcriptome Profiles Predict Response to Chemoradiotherapy

Cervical Cancer Stem-Like Cell Transcriptome Profiles Predict Response to Chemoradiotherapy

Emerging Role of Pericytes and Their Secretome in the Heart

Tumor Dormancy: Implications for Invasion and Metastasis

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