2012
DOI: 10.1155/2012/921082
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Abstract: The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovar… Show more

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Cited by 24 publications
(43 citation statements)
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“…We have generated data to show that similar two distinct populations of stem cells exist in mammalian gonads also. Interestingly similar stem cell biology persists in the mammalian gonads irrespective of sex and is possibly an evolutionarily conserved phenomenon as we have reported the same in mice, rabbits, sheep, monkey and humans [48,50].…”
Section: Our Studies On Vsels In Cord Blood and Bone Marrowsupporting
confidence: 77%
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“…We have generated data to show that similar two distinct populations of stem cells exist in mammalian gonads also. Interestingly similar stem cell biology persists in the mammalian gonads irrespective of sex and is possibly an evolutionarily conserved phenomenon as we have reported the same in mice, rabbits, sheep, monkey and humans [48,50].…”
Section: Our Studies On Vsels In Cord Blood and Bone Marrowsupporting
confidence: 77%
“…We have reported for the first time the presence of a distinct population of VSELs with nuclear OCT-4 in adult mouse [48] and human [47] testis, located towards the basement membrane of the seminiferous tubules. Besides, we also detected a progenitor stem cell population with cytoplasmic OCT-4, which was slightly bigger and had abundant cytoplasm.…”
Section: Vsels In Mammalian Testismentioning
confidence: 85%
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“…We have earlier proposed that neo-oogenesis occurs from the stem cells and surrounding epithelial cells undergo epithelial-mesenchymal transition to result in primordial follicle assembly. 2,29 Both these processes appear to be affected by chemotherapy and as mentioned earlier, further research is required in higher animal species to develop strategies to restore these processes in chemoablated ovary.…”
Section: Differentiation Potential Of Vsels That Survive Chemotherapymentioning
confidence: 97%
“…Moreover, within the adult ovarian surface epithelium, pluripotent, quiescent, very small embryonic-like stem cells (VSELs) appear to give rise to proliferating progenitor ovarian germ stem cells (OGSCs) capable of neo-oogenesis if appropriate somatic cell endocrine/paracrine signaling exists (259). If so, chemotherapy-or radiation-induced destruction of proliferating OGSCs haploid gametes, with concomitant damage to the somatic microenvironment, could impair differentiation of residual VSELs into functional gametes.…”
Section: Neo-oogenesismentioning
confidence: 99%