2016
DOI: 10.1177/1756283x16642190 View full text |Buy / Rent full text
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Abstract: Inflammatory bowel disease (IBD) is a chronic, often relapsing, condition that deeply impacts the quality of life for many patients. Although there have been significant advances in medical treatments, a large proportion of patients become refractory to available therapeutic options. Stem-cell therapy through hematopoietic stem cells (HSCs) or mesenchymal stem (stromal) cells (MSCs) is a promising therapeutic option for severe refractory cases especially when surgery is not feasible. In HSC transplantation, th… Show more

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“…However, staining for α-SMA, a marker of differentiated MSC, demonstrated that, at least in UC, the majority of PD-L1 expressing cells were identified as myofibroblasts. Further, the reduction of PD-L1 in CD may serve as a scientific rationale for the use of “PD-L1 competent” MSCs for the treatment of perianal CD where the major objective is to deposit these stem cells locally in fistulizing tracts to suppress the local inflammatory responses ( 52 ).…”
Section: Discussionmentioning
“…Transplant data from 2013 show that over 320,000 patients have received either autologous or allogeneic stem-cell transplants for various indications. 14,15 There are only a few studies reporting mesenchymal stem cell transplantation (MSCT) in IBD patients, especially in UC and several publications about MSCT in patients with pyoderma gangrenosum, but not in combination ogf these diseases. [16][17][18] In this clinical case we tried to analyze some peculiarities of clinical course in patient with UC and PG the consequences of standard treatment algorithm and MSCT applied for this patient.…”
Section: Discussionmentioning
“…Transplantation of HSCs and MSCs have shown beneficial effects in treating certain types of CD in clinical trials (Forbes et al, ; Hawkey, ; Panés et al, ), although they are believed to mainly possess immunomodulatory actions (Duran & Hommes, ; Okamoto & Watanabe, ). Nonetheless, MSCs appear indirectly to be able to promote epithelial repair by contributing to the ISCs' niche and by regulating claudin expression in TJs (Tanaka et al, ; Yabana et al, ).…”
Section: Re‐establishing Epithelial Barrier Integrity By Means Of Stementioning
“…Cell-based therapeutic strategies have been used in the clinic and are being developed for the treatment of av ariety of ailments, including Crohn's and other inflammatoryd iseases, [11] stroke, [12] cancer, [13] ando steoarthritis. [14] Taking these approachesa si nspiration, drug delivery systems where circulatory cells are used as biological vehicles are emerging as active therapeutic carriers.C ellular delivery systems have severald istinct advantages over others in terms of circulation time, inherent biocompatibility,a nd excellent in vivo distribution characteristics.…”
Section: Introductionmentioning
“…Cell‐based therapeutic strategies have been used in the clinic and are being developed for the treatment of a variety of ailments, including Crohn's and other inflammatory diseases, stroke, cancer, and osteoarthritis . Taking these approaches as inspiration, drug delivery systems where circulatory cells are used as biological vehicles are emerging as active therapeutic carriers.…”
Section: Introductionmentioning