Stem Cell- and Cell-Based Therapies for Ischemic Stroke

Nistor-Cseppentö, Delia Carmen; Jurcău, Maria Carolina; Jurcău, Anamaria; Andronie‐Cioara, Felicia Liana; Marcu, Florin

doi:10.3390/bioengineering9110717

Cited by 11 publications

(10 citation statements)

References 122 publications

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“…Cell therapy, which involves the use of primary cells, cell lines and various stem cells, has been a promising method for the treatment of difficult diseases in recent years 34 . Through transplantation and local infusion of autologous or allogeneic cells, cells and/or biologically active molecules are used to repair or enhance the biological function of damaged tissues 35 .…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Cai,

Li,

Gao

et al. 2024

Sci Rep

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Ischaemic bowel disease (ICBD) is a group of intestinal ischaemia syndromes caused by various aetiologies of reduced intestinal blood flow or vascular occlusion. ICBD can present as abdominal pain, bloody stool, and diarrhoea. This disease often occurs in middle-aged and elderly individuals with cardiovascular and cerebrovascular diseases. The incidence of ischaemic bowel disease has been increasing for decades, and it is difficult to diagnose, resulting in rapid disease progression and a high mortality rate. Therefore, fully understanding this disease, improving the diagnosis rate of this disease, and finding appropriate treatment methods are urgently needed to improve the condition and prognosis of patients. Umbilical cord blood stem cells are accessible, have weak immunogenicity, and have various biological functions, such as angiogenesis, inflammation and immune regulation. Many studies have confirmed that cord blood stem cells can relieve ischaemia, and these cells have attracted tremendous amounts of attention in regenerative medicine in recent years. In this paper, we discuss the clinical characteristics of ICBD, analyse the characteristics of human umbilical cord blood mononuclear cells (HUCB-MNCs), and use its to treat ischaemic bowel disease. Additionally, we compare the clinical manifestations and related indicators before and after treatment to evaluate the efficacy and safety of these methods.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Cai,

Li,

Gao

et al. 2024

Sci Rep

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show abstract

“…Cell transplantation is a research hotspot in the field of ischemic stroke treatment. Stem cells have the advantage of low immunogenicity, can differentiate into many types of cells as needed, and can replace damaged brain cells, thus making them the first choice for cell transplantation [ 126 ]. There are various types of stem cells used in stroke research, such as neural stem cells and mesenchymal stem cells (MSCs).…”

Section: Applications Of Plga-based Nanostructures In Cell Transplant...mentioning

confidence: 99%

The Recent Applications of PLGA-Based Nanostructures for Ischemic Stroke

Yan,

Huang,

Feng

et al. 2023

Pharmaceutics

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With the accelerated development of nanotechnology in recent years, nanomaterials have become increasingly prevalent in the medical field. The poly (lactic acid–glycolic acid) copolymer (PLGA) is one of the most commonly used biodegradable polymers. It is biocompatible and can be fabricated into various nanostructures, depending on requirements. Ischemic stroke is a common, disabling, and fatal illness that burdens society. There is a need for further improvement in the diagnosis and treatment of this disease. PLGA-based nanostructures can facilitate therapeutic compounds’ passage through the physicochemical barrier. They further provide both sustained and controlled release of therapeutic compounds when loaded with drugs for the treatment of ischemic stroke. The clinical significance and potential of PLGA-based nanostructures can also be seen in their applications in cell transplantation and imaging diagnostics of ischemic stroke. This paper summarizes the synthesis and properties of PLGA and reviews in detail the recent applications of PLGA-based nanostructures for drug delivery, disease therapy, cell transplantation, and the imaging diagnosis of ischemic stroke.

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“…Honmou et al reported that there were no major side events after the intravenous infusion of autologous BMSCs expanded in human serum into 12 participants 36-133 days post-stroke (Honmou et al, 2011). Overwhelming evidence supports the safety of the approach, although data on its efficacy are scarce or indicate only a transient improvement (Nistor-Cseppentö et al, 2022). Majority of the adverse events in these clinical trials were minor (Kvistad et al, 2022).…”

Section: Clinical Application Prospect Of Stem Cells In Strokementioning

confidence: 99%

Research hotspots and frotiers of stem cells in stroke: A bibliometric analysis from 2004 to 2022

et al. 2023

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Background: Stroke is one of the leading causes of mortality and permanent disability worldwide. However, the current stroke treatment has a limited effect. Therefore, a new treatment is urgently needed. Stem cell therapy is a cutting-edge treatment for stroke patients. This study aimed to gain better understanding of global stem cell trends in stroke via a bibliometric analysis.Methods: We used the Web of Science Core Collection to search pertinent articles about stem cells in stroke published between 2004 and 2022. Analysis was conducted using CiteSpace, VOSviewer, and the R package “bibliometrix” to identify publication outputs, countries/regions, institutions, authors/co-cited authors, journals/co-cited journals, co-cited references, and keywords.Results: A total of 6,703 publications were included in the bibliometric analysis. The total number of citations significantly and rapidly increased between 2004 and 2022, with the most pronounced growth pattern observed in the period of 2008–2009. In terms of authoritarian countries, the USA had the most publications among the countries. As for institutions and authors, the most prolific institution was the University of South Florida, followed by Oakland University and then Shanghai Jiao Tong University, and Chopp, M. and Borlongan, Cesario V, had the most output among the authors. Regarding the journals, Cell Transplantation had the highest publication, followed by Brain Research. As for references, “Mesenchymal stem cells as trophic mediators” was the most frequently cited (2,082), and the article entitled Neuronal replacement from endogenous precursors in the adult brain after stroke had the strongest burstiness (strength = 81.35). Emerging hot words in the past decade included “adhesion molecule,” “mesenchymal stromal cell,” “extracellular vesicle,” “pluripotent stem cells,” “signaling pathway,” “plasticity,” and “exosomes.”Conclusion: Between 2004 and 2022, the terms “neurogenesis,” “angiogenesis,” “mesenchymal stem cells,” “extracellular vesicle,” “exosomes,” “inflammation,” and “oxidative stress” have emerged as the hot research areas for research on stem cells in stroke. Although stem cells exert a number of positive effects, the main mechanisms for mitigating the damage caused by stroke are still unknown. Clinical challenges may include complicating factors that can affect the efficacy of stem cell therapy, which are worth a deep exploration.

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Stem Cell- and Cell-Based Therapies for Ischemic Stroke

Cited by 11 publications

References 122 publications

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

The Recent Applications of PLGA-Based Nanostructures for Ischemic Stroke

Research hotspots and frotiers of stem cells in stroke: A bibliometric analysis from 2004 to 2022

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