2004
DOI: 10.1096/fj.03-1080fje
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Given the recent demonstration that oleoylethanolamide (OEA), a cannabinoid receptor-inactive N-acylethanolamine, decreases food intake by activating the nuclear receptor PPARalpha (peroxisome proliferator-activated receptor alpha) in the periphery, we here evaluated the effects of both saturated and unsaturated C18 N-acylethanolamides (C18:0; C18:1; C18:2) in mice feeding behavior after overnight starvation. Our results show stearoylethanolamide (SEA, C18:0) exerts, unlike other unsaturated C18 homologs, a ma… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
62
1
3

Year Published

2005
2005
2007
2007

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 99 publications
(66 citation statements)
references
References 40 publications
(58 reference statements)
0
62
1
3
Order By: Relevance
“…Recent work has shown that PEA reduces inflammation in a PPAR-a-dependent manner [68]. Is this true also for other FAEs such as stearoylethanolamide, or do these molecules interact with additional members of the nuclear transcription factor family [69,70]? As these questions are progressively unraveled, we may not only gain insight on the OEA signaling system, but also identify new potential drug targets for the treatment of appetite disorders and obesity.…”
Section: Discussionmentioning
confidence: 99%
“…Recent work has shown that PEA reduces inflammation in a PPAR-a-dependent manner [68]. Is this true also for other FAEs such as stearoylethanolamide, or do these molecules interact with additional members of the nuclear transcription factor family [69,70]? As these questions are progressively unraveled, we may not only gain insight on the OEA signaling system, but also identify new potential drug targets for the treatment of appetite disorders and obesity.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, it was shown that the anti-inflammatory action of this compound could be mediated by the activation of peroxisome proliferator-activated receptor-a (PPAR-a) [11]. Furthermore, N-oleoylethanolamine has an anorexic effect via PPAR-a [12,13], and N-stearoylethanolamine is pro-apoptotic [14] and anorexic [15]. It has also been noted that these Nacylethanolamines increase markedly in degenerating tissues and cells [16 -19].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, it was shown that the anti-inflammatory action of N-palmitoylethanolamine could be mediated by the activation of peroxisome proliferator-activated receptor-␣ (PPAR-␣) (21). Furthermore, N-oleoylethanolamine was shown to be anorexic via PPAR-␣ (22,23) and N-stearoylethanolamine to be pro-apoptotic (24) and anorexic (25). In addition, NAEs have been noted to increase markedly in degenerating tissues and cells (6, 26 -28).…”
mentioning
confidence: 99%