‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption

PEGylation of magnetic poly(glycidyl methacrylate) microparticles for microfluidic bioassays

“…The difference in ZP before and after PEG-coating reached 13 mV in KCl and 14 mV in phosphate buffer, which is probably caused by the presence of a methoxy group at the end of the PEG. The results correspond with those in previously published reports 49,50 and proved that PEG was present on the microspheres. In addition to ZP, pI values of both neat and PEGylated PGMA microspheres were determined.…”

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

“…More surveys have shown that the degree to which proteins (opsonins) adsorb on to nanoparticles surface can be reduced by means of mounting the PEG density on the particle surface. Increasing the molecular weight of the PEG chains has also been shown to reduce opsonization of nanoparticles and improve retention in the circulation (Gref et al, 2000;Mahapatro and Singh, 2011). High surface density and long chain lengths of PEG are required for low protein adsorption.…”

Impact of PEG and PEG- b -PAGE modified PLGA on nanoparticle formation, protein loading and release

“…There has been an increasing interest in the past years to overcome this problem through the development of more hydrophilic PLGA derivatives, as an increased hydrophilic character is expected to improve interaction with and facilitate encapsulation of hydrophilic substances such as proteins. In this respect, the covalent linkage of polyethylene glycol (PEG) as a flexible, hydrophilic, and FDA-approved molecule to PLGA (Dumitriu and Popa, 2013) has been extensively described in literature (Gref et al, 2000;Liu et al, 2010). The…”