Steady-state and dynamic MR angiography with MS-325: initial experience in humans.

Grist, Thomas M.; Korosec, Frank R.; Peters, Dana C.; Witte, S; Walovitch, Richard C.; Dolan, Robert; Bridson, W E; Yucel, E K; Mistretta, Charles A.

doi:10.1148/radiology.207.2.9577507

Cited by 230 publications

(144 citation statements)

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“…Correlations between these parameters and histological measurements of neovasculature and macrophage content ranged from 0.74 to 0.80. Future developments in DCE-MRI of atherosclerosis may benefit from the development of new gadolinium agents with higher molecular weights to inhibit diffusion and of agents that bind to blood products such as albumin and thus remain within the blood pool (69)(70)(71). The slower kinetics of these agents may allow higher resolution imaging, where spatially resolved enhancement can be observed, for example within the fibrous cap.…”

Section: Contrast Enhancementmentioning

confidence: 99%

MRI of atherosclerosis in clinical trials

et al. 2006

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Magnetic resonance imaging (MRI) of the arterial wall has emerged as a viable technology for characterizing atherosclerotic lesions in vivo, especially within carotid arteries and other large vessels. This capability has facilitated the use of carotid MRI in clinical trials to evaluate therapeutic effects on atherosclerotic lesions themselves. MRI is specifically able to characterize three important aspects of the lesion: size, composition and biological activity. Lesion size, expressed as a total wall volume, may be more sensitive than maximal vessel narrowing (stenosis) as a measure of therapeutic effects, as it reflects changes along the entire length of the lesion and accounts for vessel remodeling. Lesion composition (e.g. lipid, fibrous and calcified content) may reflect therapeutic effects that do not alter lesion size or stenosis, but cause a transition from a vulnerable plaque composition to a more stable one. Biological activity, most notably inflammation, is an emerging target for imaging that is thought to destabilize plaque and which may be a systemic marker of vulnerability. The ability of MRI to characterize each of these features in carotid atherosclerotic lesions gives it the potential, under certain circumstances, to replace traditional trials involving large numbers of subjects and hard end-points -heart attacks and strokes -with smaller, shorter trials involving imaging end-points. In this review, the state of the art in MRI of atherosclerosis is presented in terms of hardware, image acquisition protocols and post-processing. Also, the results of validation studies for measuring lesion size, composition and inflammation will be summarized. Finally, the status of several clinical trials involving MRI of atherosclerosis will be reviewed.

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Section: Contrast Enhancementmentioning

confidence: 99%

MRI of atherosclerosis in clinical trials

et al. 2006

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“…16 Recently, testing has begun in humans of intravascular MR contrast agents that are retained within blood vessels and that selectively enhance the blood pool on T1-weighted MR images. [17][18][19][20][21] AMI-227 (Advanced Magnetics), an ultrasmall iron particle, has been shown to enhance vessels within the abdomen and chest in the steady state. 17,18 Another iron particle, NC100150 (Nycomed-Amersham), has recently entered human trials.…”

Section: Mra: Technical Considerationsmentioning

confidence: 99%

“…However, additional study is indicated before MRA can be relied on for evaluation of the mesenteric circulation. Recent improvements in scanner speed that allow contrast-enhanced aortography to be performed in Ͻ30 seconds, or within a breath-hold interval, 13,68 -70 and new blood-pool contrast agents currently under investigation 21 may allow additional improvements in this area.…”

Section: Mra Of the Thoracic And Abdominal Aortamentioning

confidence: 99%

Magnetic Resonance Angiography

Yucel¹,

Anderson²,

Edelman³

et al. 1999

Circulation

125

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“…The binding to human serum albumin reduces the extravasation of the contrast agent out of the vascular system and also leads to a high increase in relaxivity. Due to these properties MS-325 provides strong, persistent enhancement of blood vessel images (Lauffer et al 1996;Grist et al 1998). Other attempts to design blood pool contrast agents include synthesis of macromolecular gadolinium(III) chelates such as dendrimers, linear polymers, or proteins, which stay confined into blood vessels because of their large size.…”

Section: Introductionmentioning

confidence: 99%

Paramagnetic liposomes containing amphiphilic bisamide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging

et al. 2005

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Three amphiphilic DTPA bisamide derivatives containing long-chain phenylalanine esters (with 14, 16 and 18 carbon atoms in the alkyl chain) were synthesized and their corresponding gadolinium(III) complexes were prepared. The attempts to form paramagnetic micelles carrying the gadolinium(III) complexes yielded unstable or polydisperse micelles implying that the presence of the bulky aromatic side groups in the amphiphilic Gd-DTPA bisamide complexes results in an inefficient packing of the paramagnetic complex into micelles. All complexes were efficiently incorporated into liposomes consisting of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), yielding stable and monodisperse paramagnetic liposomes. All liposomes had a comparable size, typically between 120 and 160 nm. As a result of the reduced mobility of the gadolinium(III) complexes, solutions of these supramolecular structures show a higher relaxivity than solutions of Gd-DTPA. However, the relaxivity gain is lower compared to compounds consisting of purely aliphatic chains of the same length, most likely due to the less efficient packing or increased local mobility of the gadolinium(III) complex. In the case of the Gd-DTPA bisamide complex with 18 carbon atoms, the immobilization inside the liposomal structure is less effective, probably because the aliphatic chains of the complex are longer than the alkyl chains of the DPPC host, resulting in a relatively high local mobility. The paramagnetic liposomes containing the Gd-DTPA bisamide complexes with 14 carbon atoms showed the highest relaxivity because the optimal length match between the hydrophobic chains of the DPPC and the ligand allowed very efficient packing of the paramagnetic complex into the liposome.

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Steady-state and dynamic MR angiography with MS-325: initial experience in humans.

Abstract: MS-325 provides excellent vascular and selective arterial enhancement during dynamic MR angiography. The long blood residence time also allows acquisition of steady-state images of the arteries and veins with excellent spatial resolution.

Cited by 230 publications

References 0 publications

MRI of atherosclerosis in clinical trials

MRI of atherosclerosis in clinical trials

Magnetic Resonance Angiography

Paramagnetic liposomes containing amphiphilic bisamide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging

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