Status of colitis-associated cancer in ulcerative colitis

Kinugasa, Tetsushi; Akagi, Yoshito

doi:10.4251/wjgo.v8.i4.351

Cited by 54 publications

(37 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TLR pathway, increases the risk of colitis-associated CRC due to commensal gut microbiota (39,40). TLRs play an important role in immunity and are expressed in various cell types, including tumor cells (41,42).…”

Section: Discussionmentioning

confidence: 99%

The role of Vitamin D Receptor gene polymorphisms in colorectal cancer risk

Messaritakis

Koulouridi

Sfakianaki

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Vitamin D deficiency has been associated with increased colorectal cancer (CRC) incidence risk and mortality. Vitamin D mediates its action through binding of the vitamin D receptor (VDR) and polymorphisms of the VDR might explain these inverse associations. Methods: The aim of the study was the investigation of TaqI, ApaI, FokI and BsmI polymorphisms of the VDR gene for their relevance to colorectal carcinogenesis and progression. Peripheral blood was obtained from 397 patients with early operable stage II/III (n=202) and stage IV (n=195) CRC. Moreover, samples from 100 healthy donors and 40 patients with adenomatous polyps were also included as control groups. Genotyping in samples from patients and controls was performed using PCR-RFLP. Results: A significant association revealed between all four polymorphisms and cancer. Individuals with homozygous mutant (tt, aa, ff or bb) genotype are more susceptible to the disease (p<0.001). All mutant genotypes detected were also significantly associated with the stage IV disease (p<0.001) leading to significantly decreased survival (p<0.001). Moreover, all four polymorphisms were significantly associated with KRAS mutations and with TLR2, TLR4 and TLR9 genetic variants. In multivariate analysis, tt, aa and ff genotypes emerged as independent factors associated with decreased OS (p=0.001, p<0.001 and p=0.001, respectively). Conclusions: The detection of higher frequencies of the VDR polymorphisms in CRC patients highlights the role of these polymorphisms in cancer development and progression.

show abstract

Section: Discussionmentioning

confidence: 99%

The role of Vitamin D Receptor gene polymorphisms in colorectal cancer risk

Messaritakis

Koulouridi

Sfakianaki

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…In either situation, the cancer develops from acquiring hallmark molecular alterations in the epithelium of the colon and rectum. Regrettably, 20 to 50% of UC patients with CAC were diagnosed with dysplasia only in the preoperative pathological diagnosis (13). This indicates the difficulty of surveillance for UC patients using colonoscopy.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑449a is a potential predictor of colitis‑associated colorectal cancer progression

Feng

Song

et al. 2018

Oncol Rep

View full text Add to dashboard Cite

An early diagnosis of colitis‑associated colorectal cancer (CAC) is important for its clinical management. However, it is currently difficult to distinguish the different stages of CAC development. MicroRNA dysregulation is common in human colorectal disorders, however little is known regarding whether miRNA affects tumor progression by regulating inflammation. In the present study, we identified a novel miRNA (miR‑449a), the expression of which was significantly reduced in CAC tissues than in paired adjacent non‑cancerous tissues (ANTs). Notably, the level of miR‑449a was in a markedly decreased pattern during the neoplastic transformation of ulcerative colitis (UC)‑to‑CAC, as demonstrated by both clinical investigations and the experimental mouse model induced by AOM/DSS treatment. In addition, we observed that decreased miR‑449a expression was associated with advanced T or N status, later clinical stage and poor histological differentiation of CAC. Mechanistic studies revealed that miR‑449a inhibited the growth and metastasis of human colon cancer cells by directly binding to the 3'‑UTR of Notch‑1 and thereby, suppressed the activation of the Notch signaling pathway. Therefore, these findings provide strong evidence for the translational potential of miR‑449a in the discrimination of patients with UC that is likely to progress into CAC, from those unlikely to progress, as well as in the prognosis and diagnosis of CAC.

show abstract

“…Ulcerative colitis are an important risk factor for the development of colon cancer. Several reports suggest that the rate of colon cancer is increasing in ulcerative colitis 21,37, 38 . Aspirin has been associated In ulcerative colitis, there are reduced in the number of goblet cells (goblet cell depletion) and thinner colonic mucus layer.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Activity of Indonesian Soybean in comparison with Soybean Meal on Goblet Cell Count and Micro Vessel Density in Colitis-Associated Mouse Colon Carcinogenesis

Putri¹,

Kusmardi²,

Elya³

2017

IJPTR

View full text Add to dashboard Cite

: Colon cancer is a major public health problem throughout the worldwide. Recently, many studies have focused on finding chemoprevention based on the natural compound. The present study was aimed to investigate the inhibitory activity of Indonesian soybean in comparison with soybean meal extract in colitis-associated mouse colon carcinogenesis. Methods: In this study, Swiss Webster mice were induced by azoxymethane 10 mg/kg body weight followed by administration of 2% dextran sodium sulfate during a week. Soybean, soybean meal extract at each dose of 75, 150, and 200 mg daily and aspirin 0,39 mg/kg body weight daily (equivalent to 150 mg for a 70 kg human) administered orally. Histopathological examination of the colon tissue (hematoxylin-eosin staining) was done by counting the number of goblet cells and micro vessel density in ten randomly selected fields visual. The results: Soybean and soybean meal significantly reduced the count of goblet cell (P<0,05) in colitis-associated colon carcinogenesis mice. Soybean extract is also significantly reduced the number of micro vessel density (P<0,001) in colitis-associated colon carcinogenesis mice. Otherwise, there were no significant effects of the soybean meal extract on the number of micro vessel density in colitis-associated colon carcinogenesis mice. Conclusion: Our results indicate that Indonesian soybean and soybean meal extract may have inhibitory activity in colitis-associated colon carcinogenesis through inhibiting reduction in the number of goblet cell and micro vessel density. Indonesian soybean may have Inhibitory activity better than soybean meal.

show abstract

Status of colitis-associated cancer in ulcerative colitis

Cited by 54 publications

References 45 publications

The role of Vitamin D Receptor gene polymorphisms in colorectal cancer risk

The role of Vitamin D Receptor gene polymorphisms in colorectal cancer risk

MicroRNA‑449a is a potential predictor of colitis‑associated colorectal cancer progression

Inhibitory Activity of Indonesian Soybean in comparison with Soybean Meal on Goblet Cell Count and Micro Vessel Density in Colitis-Associated Mouse Colon Carcinogenesis

Contact Info

Product

Resources

About