Statistical modeling of extracellular vesicle cargo to predict clinical trial outcomes for hypoplastic left heart syndrome

Hoffman, Jessica R.; Park, Hyun-Ji; Bheri, Sruti; Platt, Manu O.; Hare, Joshua M.; Kaushal, Sunjay; Bettencourt, Judith L.; Lai, Dejian; Slesnick, Timothy C.; Mahle, William T.; Davis, Michael E.

doi:10.1016/j.isci.2023.107980

iScience

2023

DOI: 10.1016/j.isci.2023.107980

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Statistical modeling of extracellular vesicle cargo to predict clinical trial outcomes for hypoplastic left heart syndrome

Jessica R. Hoffman,

Hyun-Ji Park,

Sruti Bheri

et al.

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2024

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Cardiomyocyte proliferation and regeneration in congenital heart disease

Liang,

He,

Wang

2024

Pediatric Discovery

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Despite advances in prenatal screening and a notable decrease in mortality rates, congenital heart disease (CHD) remains the most prevalent congenital disorder in newborns globally. Current therapeutic surgical approaches face challenges due to the significant rise in complications and disabilities. Emerging cardiac regenerative therapies offer promising adjuncts for CHD treatment. One novel avenue involves investigating methods to stimulate cardiomyocyte proliferation. However, the mechanism of altered cardiomyocyte proliferation in CHD is not fully understood, and there are few feasible approaches to stimulate cardiomyocyte cell cycling for optimal healing in CHD patients. In this review, we explore recent progress in understanding genetic and epigenetic mechanisms underlying defective cardiomyocyte proliferation in CHD from development through birth. Targeting cell cycle pathways shows promise for enhancing cardiomyocyte cytokinesis, division, and regeneration to repair heart defects. Advancements in human disease modeling techniques, clustered regularly interspaced short palindromic repeats ‐based genome and epigenome editing, and next‐generation sequencing technologies will expedite the exploration of abnormal machinery governing cardiomyocyte differentiation, proliferation, and maturation across diverse genetic backgrounds of CHD. Ongoing studies on screening drugs that regulate cell cycling are poised to translate this nascent technology of enhancing cardiomyocyte proliferation into a new therapeutic paradigm for CHD surgical interventions.

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Cardiomyocyte proliferation and regeneration in congenital heart disease

Liang,

He,

Wang

2024

Pediatric Discovery

View full text Add to dashboard Cite

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Statistical modeling of extracellular vesicle cargo to predict clinical trial outcomes for hypoplastic left heart syndrome

Cited by 1 publication

References 34 publications

Cardiomyocyte proliferation and regeneration in congenital heart disease

Cardiomyocyte proliferation and regeneration in congenital heart disease

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