Statistical methods in functional magnetic resonance imaging with respect to nonstationary time‐series: Auditory cortex activity

Gaschler‐Markefski, Birgit; Baumgart, Frank; Tempelmann, Claus; Schindler, Frank; Stiller, Detlet; Heinze, HJ; Scheich, Henning

doi:10.1002/mrm.1910380518

Cited by 37 publications

(26 citation statements)

References 50 publications

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“…Functional images of which gray values deviated of more than 2.5% from the grand average were excluded from further analysis. A minimum of 20 images has to be left for each condition to perform cross-correlations with an alpha error of 5% and a corresponding beta error of 30% for an effect value of 0.8 as recommended for small sample sizes, that is, for small numbers of pairs of comparison (stimulus versus reference) [Gaschler-Markefski et al, 1997]. Therefore, a significance level of 5% error probability was chosen.…”

Section: Discussionmentioning

confidence: 99%

“…After mean intensity adjustment of each slice, data sets were corrected for in-plane motion between successive images using the three parameter inplane rigid body model of BrainVoyager 2 . Functional activation was determined by correlation analysis to obtain statistical parametric maps [Bandettini et al, 1993;Gaschler-Markefski et al, 1997]. A trapezoid function, roughly modeling the expected blood-oxygen-level-dependent (BOLD) response, served as correlation vector with the time series of gray value change of each voxel.…”

Section: Discussionmentioning

confidence: 99%

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FMRI activations of amygdala, cingulate cortex, and auditory cortex by infant laughing and crying

Sander¹,

Frome²,

Scheich³

2007

Human Brain Mapping

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112

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One of the functions of emotional vocalizations is the regulation of social relationships like those between adults and children. Listening to infant vocalizations is known to engage amygdala as well as anterior and posterior cingulate cortices. But, the functional relationships between these structures still need further clarification. Here, nonparental women and men listened to laughing and crying of preverbal infants and to vocalization-derived control stimuli, while performing a pure tone detection task during low-noise functional magnetic resonance imaging. Infant vocalizations elicited stronger activation in amygdala and anterior cingulate cortex (ACC) of women, whereas the alienated control stimuli elicited stronger activation in men. Independent of listeners' gender, auditory cortex (AC) and posterior cingulate cortex (PCC) were more strongly activated by the control stimuli than by infant laughing or crying. The gender-dependent correlates of neural activity in amygdala and ACC may reflect neural predispositions in women for responses to preverbal infant vocalizations, whereas the gender-independent similarity of activation patterns in PCC and AC may reflect more sensory-based and cognitive levels of neural processing. In comparison to our previous work on adult laughing and crying, the infant vocalizations elicited manifold higher amygdala activation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

FMRI activations of amygdala, cingulate cortex, and auditory cortex by infant laughing and crying

Sander¹,

Frome²,

Scheich³

2007

Human Brain Mapping

Self Cite

112

View full text Add to dashboard Cite

show abstract

“…Functional images of which gray values deviated more than 2.5% from the mean gray value were excluded from further analysis. A minimum of 20 images has to be left for each condition to perform cross-correlations with an alpha error of 5% and a corresponding beta error of 30% for an effect value of 0.8 as recommended for small sample sizes, that is, for small numbers of pairs of comparison (stimulus vs. reference) (Gaschler-Markefski et al, 1997). Therefore, a significance level of 5% error probability was chosen.…”

Section: Discussionmentioning

confidence: 99%

Left Auditory Cortex and Amygdala, but Right Insula Dominance for Human Laughing and Crying

Sander

Scheich

2005

Journal of Cognitive Neuroscience

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Evidence suggests that in animals their own species-specific communication sounds are processed predominantly in the left hemisphere. In contrast, processing linguistic aspects of human speech involves the left hemisphere, whereas processing some prosodic aspects of speech as well as other not yet well-defined attributes of human voices predominantly involves the right hemisphere. This leaves open the question of hemispheric processing of universal (species-specific) human vocalizations that are more directly comparable to animal vocalizations. The present functional magnetic resonance imaging study addresses this question. Twenty subjects listened to human laughing and crying presented either in an original or time-reversed version while performing a pitch-shift detection task to control attention. Time-reversed presentation of these sounds is a suitable auditory control because it does not change the overall spectral content. The auditory cortex, amygdala, and insula in the left hemisphere were more strongly activated by original than by time-reversed laughing and crying. Thus, similar to speech, these nonspeech vocalizations involve predominantly left-hemisphere auditory processing. Functional data suggest that this lateralization effect is more likely based on acoustical similarities between speech and laughing or crying than on similarities with respect to communicative functions. Both the original and time-reversed laughing and crying activated more strongly the right insula, which may be compatible with its assumed function in emotional self-awareness.

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“…For visual areas outside V1, a purely anatomical identification is also quite reliable for V5, which lies at the intersection of the ascending limb of the inferior temporal sulcus and the lateral occipital sulcus (Watson et al, 1993;Walters et al, 2003). The primary auditory cortex has a clear spatial relationship with Heschl's gyrus (Gaschler-Markefski et al, 1997;Rademacher et al, 2001). All these functional domains are relevant in relation to migraine aura symptoms.…”

Section: Functional Domains and Anatomical Landmarksmentioning

confidence: 99%

Hot spots and labyrinths: Why neuromodulation devices for episodic migraine should be personalized

Dahlem

Schmidt

Bojak

et al. 2014

Preprint

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Stimulation protocols for medical devices should be rationally designed. For episodic migraine with aura we outline model-based design strategies towards preventive and acute therapies using stereotactic neuromodulation. To this end, we regard a localized spreading depression (SD) wave segment as a central element in migraine pathophysiology. To describe nucleation and propagation features of the SD wave segment, we define the new concepts of cortical hot spots and labyrinths, respectively. In particular, we firstly focus exclusively on curvature-induced dynamical properties by studying a generic reaction-diffusion model of SD on the folded cortical surface. This surface is described with increasing level of details, including finally personalized simulations using patient's magnetic resonance imaging (MRI) scanner readings. At this stage, the only relevant factor that can modulate nucleation and propagation paths is the Gaussian curvature, which has the advantage of being rather readily accessible by MRI. We conclude with discussing further anatomical factors, such as areal, laminar, and cellular heterogeneity, that in addition to and in relation to Gaussian curvature determine the generalized concept of cortical hot spots and labyrinths as target structures for neuromodulation.Our numerical simulations suggest that these target structures are like fingerprints, they are individual features of each migraine sufferer. The goal in the future will be to provide individualized neural tissue simulations. These simulations should predict the clinical data and therefore can also serve as a test bed for exploring stereotactic neuromodulation.

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Statistical methods in functional magnetic resonance imaging with respect to nonstationary time‐series: Auditory cortex activity

Cited by 37 publications

References 50 publications

FMRI activations of amygdala, cingulate cortex, and auditory cortex by infant laughing and crying

FMRI activations of amygdala, cingulate cortex, and auditory cortex by infant laughing and crying

Left Auditory Cortex and Amygdala, but Right Insula Dominance for Human Laughing and Crying

Hot spots and labyrinths: Why neuromodulation devices for episodic migraine should be personalized

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