Statistical localization of human olfactory cortex

Seubert, Janina; Freiherr, Jessica; Djordjević, Jelena; Lundström, Johan N.

doi:10.1016/j.neuroimage.2012.10.030

Cited by 164 publications

(186 citation statements)

References 97 publications

Supporting

Mentioning

173

Contrasting

Order By: Relevance

“…The area's coordinates are located somewhat posterior and lateral to the coordinates of the olfactory orbitofrontal cortex, as determined by neuroimaging meta-analysis studies (Gottfried and Zald, 2005;Seubert et al, 2012). Interestingly, the coordinates agree better with olfactory projection areas based on animal studies, as reviewed by (Gottfried and Zald, 2005).…”

Section: Discussionmentioning

confidence: 74%

Brain structure is changed in congenital anosmia

et al. 2013

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 74%

Brain structure is changed in congenital anosmia

et al. 2013

View full text Add to dashboard Cite

“…Olfactory sickness (Fig. 3B) was related to increased activation of the mediodorsal thalamus (MDT) and of the odor perception network (27), including the orbitofrontal cortex (OFC), the entorhinal/piriform cortex, and the inferior frontopolar and middle frontal gyrus. The odor perception network is susceptible to attention and learning (28), as well as threat processing (24).…”

Section: Discussionmentioning

confidence: 99%

Behavioral and neural correlates to multisensory detection of sick humans

Regenbogen

Axelsson

Lasselin

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

119

110

View full text Add to dashboard Cite

Throughout human evolution, infectious diseases have been a primary cause of death. Detection of subtle cues indicating sickness and avoidance of sick conspecifics would therefore be an adaptive way of coping with an environment fraught with pathogens. This study determines how humans perceive and integrate early cues of sickness in conspecifics sampled just hours after the induction of immune system activation, and the underlying neural mechanisms for this detection. In a double-blind placebo-controlled crossover design, the immune system in 22 sample donors was transiently activated with an endotoxin injection [lipopolysaccharide (LPS)]. Facial photographs and body odor samples were taken from the same donors when "sick" (LPS-injected) and when "healthy" (saline-injected) and subsequently were presented to a separate group of participants (n = 30) who rated their liking of the presented person during fMRI scanning. Faces were less socially desirable when sick, and sick body odors tended to lower liking of the faces. Sickness status presented by odor and facial photograph resulted in increased neural activation of odor-and faceperception networks, respectively. A superadditive effect of olfactory-visual integration of sickness cues was found in the intraparietal sulcus, which was functionally connected to core areas of multisensory integration in the superior temporal sulcus and orbitofrontal cortex. Taken together, the results outline a disease-avoidance model in which neural mechanisms involved in the detection of disease cues and multisensory integration are vital parts.body odor | lipopolysaccharide | endotoxin | sickness cues | disease avoidance

show abstract

“…The seed time courses were extracted from the preprocessed data as described above. Seeds comprising the core ON were obtained from a meta-analysis that identified these two regions as most likely to be activated by olfactory stimulation [14] and , and were obtained from a meta-analysis contrasting chemical stimulation versus baseline [21], as well as the conjunction of chemical/mechanical (right insula) and chemical/electrical (left insula) stimulations. Coordinates reported by Iannilli et al [21] were in Talairach space and were converted into MNI space by the Brett transform using GingerALE software [22].…”

Section: Methodsmentioning

confidence: 99%

“…In contrast, the primary olfactory network (ON) is linked to conscious memory processing [10] and shows a high correlation between olfactory sensory impairment and age-related memory decline [11], which is a risk factor for developing dementia [12,13]. The core ON includes the orbitofrontal cortex (OFC) and the piriform region in the anterior temporal cortex, and extends into the amygdala [14] and episodic memory systems [15,16].…”

Section: Introductionmentioning

confidence: 99%

Intrinsic intranasal chemosensory brain networks shown by resting-state functional MRI

2016

View full text Add to dashboard Cite

The human brain is organized into functional networks for sensory-motor and cognitive processing. Intrinsic networks are detectable in the absence of stimulation or task demands, whereas extrinsic networks are detectable when stimulated by sensory or cognitive demands. Intranasal chemosensory processing relies on two dissociable networks for processing incoming trigeminal and olfactory stimulation, but it is not known whether these networks are intrinsically organized. The aim of this study was to identify whether brain networks for intranasal chemosensory processing are detectable in functional connectivity resting-state functional MRI (fMRI). Sixteen healthy adults participated in a 5-min resting-state fMRI study. Functional connectivity seeds were defined from coordinates that anchor olfactory (i.e. bilateral piriform and orbitofrontal cortex) and trigeminal (bilateral anterior insula and cingulate cortex) networks in published task activation studies, and the resulting networks were thresholded at P less than 0.001. The olfactory network showed extended functional connectivity to the thalamus, medial prefrontal cortex, caudate, nucleus accumbens, parahippocampal gyrus, and hippocampus. The trigeminal network showed extended functional connectivity to the precuneus, thalamus, caudate, brainstem, and cerebellum. Both networks overlapped in the thalamus, caudate, medial prefrontal cortex, and insula. These results show that brain networks for intranasal chemosensory processing are intrinsically organized, not just extrinsically instantiated in response to task demands, and resemble networks for processing olfactory and trigeminal stimulation. As such, it may be possible to study the functional organization and dynamics of the olfactory network in resting-state fMRI as well as its implications for aging and disease.

show abstract

Statistical localization of human olfactory cortex

Cited by 164 publications

References 97 publications

Brain structure is changed in congenital anosmia

Brain structure is changed in congenital anosmia

Behavioral and neural correlates to multisensory detection of sick humans

Intrinsic intranasal chemosensory brain networks shown by resting-state functional MRI

Contact Info

Product

Resources

About