Statistical data processing of mobility curves of univalent weak bases

Abstract

This paper brings a new rigorous and complete statistical approach to the data processing of the mobility curves of univalent weak bases. This approach is based on application of the least square method to the equation of the related mobility curve. Thus, an equation for the best fit is derived and its mathematical solution is found. The solution brings best estimates of the mobility curve parameters, i.e., dissociation constant K and ionic mobility of the protonated base U. Further, explicit formulas have been derived for the calculation of related statistical parameters, i.e., SDs of effective mobility s(u), of the dissociation constant s(K), and of ionic mobility of protonated base s(U). The mathematical functions used in the above approach do not impose any limitations on the data used, i.e., the mobility and pH values used may be real numbers (positive, negative, zero).

Determination of thermodynamic acidity constants and limiting ionic mobilities of weak electrolytes by capillary electrophoresis using a new free software AnglerFish

“…There were many attempts to use CZE to determine both pKa and ionic mobilities, see, for example, Refs. []. Šlampová et al.…”

“…Šlampová et al. attempted to correct both pKas and ionic mobilities for ionic effects. Šlampová’s approach was limited to singly charged weak electrolytes and required that all experimental data be measured at the same ionic strength.…”