Statins for prevention of atrial fibrillation after cardiac surgery: A systematic literature review

Abstract

Our meta-analysis provides evidence that preoperative statin therapy is associated with a reduction in the incidence of atrial fibrillation after cardiac surgery.

Secondary Prevention After Coronary Artery Bypass Graft Surgery

“…[99][100][101][102] Through antisympathetic activity and the stabilization of ion channels, 103 both randomized and observational studies have illustrated that statin treatment significantly reduces the risk of AF after CABG both in the perioperative period and long term after surgery. [104][105][106][107][108][109][110] Although selection bias cannot be excluded, several nonrandomized, retrospective studies have noted significant associations between perioperative statin use and a lower risk of postoperative renal dysfunction, 111,112 infection, 113 stroke, [114][115][116] and mortality, 111,[116][117][118] even among patients without elevated lipid profiles before surgery. 119 Some investigators have suggested that preoperative statin treatment may reduce the risk of mortality late after surgery, 117,[120][121][122] but it is also possible that preoperative statin administration simply predicts those who will receive statins after surgery, 123 ultimately leading to improved long-term outcomes.…”

Statin for Prevention of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting in Japanese Patients

“…21 In this meta-analysis the majority of patients (97.7%, 17,002 patients) underwent surgery with cardiopulmonary bypass. Song et al investigated the preventive effects of atorvastatin on the incidence of AF after elective off-pump coronary artery bypass surgery.…”

Predictors of short- and mid-term recurrence of atrial fibrillation after surgical radiofrequency ablation: A six-month transtelephonic electrocardiogram monitoring study

“…Preoperative use of antiarrhythmic drugs and statins in our patients resulted in less frequent recurrence of arrhythmia. The ARMYDA-3 study showed that statins reduced the incidence of POAF [14,15]. Statins are recommended for prophylaxis of arrhythmia in patients following coronary artery bypass grafting, irrespectively of heart valve surgery.…”