Static and fatigue mechanical behavior of bone cement with elevated barium sulfate content for treatment of vertebral compression fractures

Kurtz, Steven M.; Villarraga, Marta L.; Zhao, Kaiyue; Edidin, Avram A.

doi:10.1016/j.biomaterials.2004.09.055

Cited by 97 publications

(92 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, as highlighted by Kurtz et al and Makita et al, the static and fatigue properties of PMMA-based bone cement are not necessarily compromised by the addition of barium sulfate within 30%. 28,29 In conclusion, the results highlighted that the infection is resolved by a prompt and high release of antimicrobial drugs, which are able to eliminate the bacteria in osteomyelitis.…”

mentioning

confidence: 81%

Microbiological and pharmacological tests on new antibiotic‐loaded PMMA‐based composites for the treatment of osteomyelitis

Giavaresi

Minelli

Sartori

et al. 2011

Journal Orthopaedic Research

View full text Add to dashboard Cite

Local antibiotic diffusion in rabbit femurs from two new PMMA-based and nail-shaped composites, enriched with btricalcium phosphate (P-TCP) and BaSO 4 or only with BaSO 4 (P-BaSO 4 ), and soaked in a solution of gentamicin (G) and vancomycin (V) was studied. Nails were implanted into the intramedullary cavity of healthy and osteomyelitic femurs to study the resolution of infection and to quantify the antibiotic penetration into bone by microbiological, pharmacological, and histological tests. A significant progression of osteomyelitis was recorded 7 weeks after MRSA inoculation, whereas no bacteria were found in animals treated with antibiotic-loaded nails as confirmed by microbiology and histology (Smeltzer score). The release of both antibiotics from composites was high and prompt both in healthy and infected bone; the amount of V was higher than that of G in all bone samples. Antibiotics of both composites were still present in bone 3 weeks after nail implantation. The P-BaSO4 composite released a lower amount of antibiotics than did P-TCP. The G-V combination in vivo exerted a synergistic bactericidal effect, which was confirmed by microbiological, histological, and clinical results (no infection). These new porous PMMA composites, soaked in G-V solution in the operating room, might be an effective and useful drug delivery system for osteomyelitis treatment. ß

show abstract

mentioning

confidence: 81%

Microbiological and pharmacological tests on new antibiotic‐loaded PMMA‐based composites for the treatment of osteomyelitis

Giavaresi

Minelli

Sartori

et al. 2011

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…Most commercial acrylic bone cements exhibit a compressive strength and elastic modulus in the range of 85-114 MPa and 1700-3700 MPa, respectively 13,14 . The apparent compressive strength and elastic modulus of cancellous bone, on the other hand, is typically in the ranges of 0.1-15 MPa and 10-900 MPa [15][16][17] , respectively, encompassing osteoporotic to healthy bone.…”

Section: Introductionmentioning

confidence: 99%

Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acid-modified bone cement in a bovine model

López

Mestres

Ott

et al. 2014

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

PostprintThis is the accepted version of a paper published in Journal of The Mechanical Behavior of Biomedical Materials. This paper has been peer-reviewed but does not include the final publisher proofcorrections or journal pagination. Citation for the original published paper (version of record):López, A., Mestres, G., Karlsson Ott, M., Engqvist, H., Ferguson, S. et al. (2014) Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acidmodified bone cement in a bovine model. Journal of The Mechanical AbstractAdjacent vertebral fractures are a common complication experienced by osteoporosis patients shortly after vertebroplasty. Whether these fractures are due to the bone cement properties, the cement filling characteristics or to the natural course of the disease is still unclear. However, some data suggests that such fractures might occur because of an imbalance in the load distribution due to a mismatch between the elastic modulus (E) of the bonecement composite, and that of the vertebral cancellous bone. In this study, the properties of bone-compliant linoleic acid-modified bone cements were assessed using a bovine vertebroplasty model. Two groups of specimens (cementonly and bone-cement composites), and four subgroups comprising bone cements with elastic moduli in the range of 870-3500 MPa were tested to failure in uniaxial compression. In addition, monomer release as well as time and concentration-dependent cytocompatibility was assessed through the cement extracts using a Saos-2 cell model.Composites augmented with bone-compliant cements exhibited a reduction in E despite of their relatively high bone volume fraction (BVF). Moreover, a significant positive correlation between the BVF and E for the composites augmented with 870 MPa modulus cements was found. This was attributed to the increased relative contribution of the bone to the mechanical properties of the composites with a decrease in E of the bone cement. The use of linoleic acid reduced monomer conversion resulting in six times more monomer released after 24 hours. However, the cytocompatibility of the bone-compliant cements was comparable to that of the unmodified cements after the extracts were diluted four times. This study represents an important step towards introducing viable bone-compliant bone cements into vertebroplasty practice.

show abstract

“…In this study, a most negative scenario of vertebrectomy situation was applied, where the implant inserts are embedded in vertebral body-like pieces and need to bear presso-flexion. The bone quality of spine determines the characteristics of the fixation screws and stabilizer plate implants [4]. Spinal implant systems for posterior fixation must be made of a good biologically responsive biomaterial and have biomechanical stability [5].…”

Section: Introductionmentioning

confidence: 99%

A Study of the Dynamic Anterior Cervical Plate Implant by Computer Aided Virtual Engineering Method

Karaçalı

2017

Acta Phys. Pol. A

View full text Add to dashboard Cite

The convenience of dynamic anterior cervical PMMA biomaterial placement of spinal implants is considered by finite element modeling. The maximum fatigue behavior was also studied in surface coated Ti-5Al-2.55n spinal screw-rods. Anterior cervical biomaterial plates reduce the hazard for spinal cord injury and provide outstanding fixation for the anterior column, to stop the relocation and slackening of screws-rods by a cross-split screw crown that may be fastened into the biomaterial plate. This article reports about the hollow Ti-5Al-2.55n screw and cervical biomaterial PMMA plate system. The flexion movement of the spine implant was modeled to control the stresses and strains of the bone and screw interfaces under the external forces, as well as motion of the vertebrae by finite element modeling. This computational engineering analysis is aimed to support patients suffering anterior cervical arthrodesis after degenerative disease or trauma. The data from this research may provide an essential base to estimate the stabilization quality. A model for the biomaterial between C4 and C6 segments of vertebrae of cervical spine was obtained. Study of the cervical biomaterial implant provides instantaneous secure fixation virtual experiment with minimal complications, before the real implant surgery, using computer aided virtual engineering.

show abstract

Static and fatigue mechanical behavior of bone cement with elevated barium sulfate content for treatment of vertebral compression fractures

Cited by 97 publications

References 15 publications

Microbiological and pharmacological tests on new antibiotic‐loaded PMMA‐based composites for the treatment of osteomyelitis

Microbiological and pharmacological tests on new antibiotic‐loaded PMMA‐based composites for the treatment of osteomyelitis

Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acid-modified bone cement in a bovine model

A Study of the Dynamic Anterior Cervical Plate Implant by Computer Aided Virtual Engineering Method

Contact Info

Product

Resources

About