State-of-the-art myocardial strain by CMR feature tracking: clinical applications and future perspectives

Xu, Jing; Yang, Wenjing; Zhao, Shihua; Lu, Minjie

doi:10.1007/s00330-022-08629-2

Cited by 69 publications

(47 citation statements)

References 100 publications

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“…Recently, the strong prognostic power of myocardial strain derived from tissue tracking has been shown closely related to impaired cardiac damage 28 . In current study, the absolute value of GRS, GCS, GLS, and PDRS showed negative changes as the exercise capacity increased.…”

Section: Discussionmentioning

confidence: 45%

The Role of MR Assessments of Cardiac Morphology, Function, and Tissue Characteristics on Exercise Capacity in Well‐Functioning Older Adults

Zhong

et al. 2022

Magnetic Resonance Imaging

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Background: The relationship between resting cardiac indices and exercise capacity in older adults was still not well understood. New developments in cardiac magnetic resonance imaging (MRI) enable a much fuller assessment of cardiac characteristics. Purpose/Hypothesis: To assess the association between exercise capacity and specific aspects of resting cardiac structure, function, and tissue. Study Type: Cross-sectional study. Population: A total of 112 well-functioning older adults (mean age 69 years, 52 men). Field Strength/Sequence: All participants underwent 3.0 T MRI, using scan protocols including balanced steady-state free precession cine sequence, modified look-locker inversion recovery, and T2-prepared single-shot balanced steady-state free precession. Assessment: Demographic and geriatric characteristics were collected. Blood samples were assayed for lipid and glucose related biomarkers. All participants performed a symptom-limited cardiopulmonary exercise test to achieve peakVO 2 . Cardiac MRI parameters were measured with semi-automatic software by S.Y., an 18-year experienced radiologist. Statistical Tests: Demographic, geriatric characteristics and MR measurements were compared among quartiles of peakVO2, with different methods according to the data type. Spearman's partial correlation and least absolute shrinkage selection operator regression were performed to select significant MR features associated with peakVO 2 . Mediation effect analysis was conducted to test any indirect connection between age and peakVO 2 . A two-sided P value of <0.05 was defined statistical significance. Results: Epicardial fat volume, left atrial volume indexed to height, right ventricular end-systolic volume indexed to body surface area and global circumferential strain (GCS) were correlated with peakVO 2 (regression coefficients were À0.040, À0.093, 0.127, and 0.408, respectively). Mediation analysis showed that the total effect of peakVO 2 change was 43.6% from the change of age. The proportion of indirect effect from epicardial fat volume and GCS were 11.8% and 15.1% in total effect, respectively. Data Conclusion: PeakVO 2 was associated with epicardial fat volume, left atrial volume, right ventricular volume and GCS of left ventricle.

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Section: Discussionmentioning

confidence: 45%

The Role of MR Assessments of Cardiac Morphology, Function, and Tissue Characteristics on Exercise Capacity in Well‐Functioning Older Adults

Zhong

et al. 2022

Magnetic Resonance Imaging

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“…A growing body of evidence, including our ndings, had demonstrated that GLS with FT-CMR could be used as a prognosticator and a basis for the risk strati cation of STEMI patients at the early stage. However, the limitations of feature-tracking CMR derived strains were also apparent, including relatively lower spatial and temporal resolution compared with speckle tracking echocardiography or CMR tagging, deviations due to the through-plane myocardial motion, variabilities brought by the manual drawing of the myocardial contours [23,24]. Some advanced technologies like three-dimension FT-CMR could partly solved the problems above.…”

Section: Predictors Of Lvarmentioning

confidence: 99%

Early Cardiac Magnetic Resonance-derived Cardiac Strain as a Predictor of Adverse Events and Ventricular Remodeling in Patients with Reperfused STEMI: A Two-center Cohort Study

Zhou

Lü

Wang

et al. 2023

Preprint

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Purpose The main purpose of this study was to investigate the predictive value of cardiac magnetic resonance (CMR)-derived strains for post-infarction left ventricular adverse remodeling (LVAR) and clinical events in an East Asian patient cohort of ST-segment elevation myocardial infarction (STEMI). Methods Patients diagnosed with STEMI and treated with primary percutaneous coronary intervention (PCI) comprising stent implantation at Chinese two centers were enrolled in this prospective cohort study. All participants underwent CMR imaging early after stenting. Feature tracking was used to assess left ventricular (LV) strains. The primary endpoints were major adverse cardiac events (MACE) and LVAR (defined as 15% increase in LV end-diastolic volume) in 6-month follow up. Results Among the 76 patients included (age 55.5 ± 10.7 years; 88% male), 18 (23.7%) experienced a MACE event. Global longitudinal strain (GLS) revealed by FT-CMR was confirmed to be the independent predictor of MACE (OR = 1.21 (1.07–1.36); P = 0.001). The area under the ROC curve was 0.763. The best cutoff value of GLS for predicting MACE was − 14.6%, with a diagnostic sensitivity of 72.2% and a diagnostic specificity of 74.2%. LVAR was found in 7 patients (29.2%) among the 24 patients underwent CMR imaging at 6-month follow-up time. GLS was an independent predictor of LVAR (OR = 2.06 (1.14–3.73); P = 0.017). Conclusion In STEMI patients treated with primary PCI, GLS determined on early CMR could be an independent predictor of MACE and LVAR.

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“…Currently, cardiac magnetic resonance (CMR) is the non-invasive gold standard imaging modality for the diagnosis and follow-up of myocarditis, the diagnostic criteria being referred to as “Lake Louis Criteria” (LLC) [ 6 , 7 ]. Myocardial strain, acquired using the CMR feature tracking (FT) technique, quantifies atrial and ventricular systolic function in different dimensions, with left atrial (LA) and biventricular strains proving to have diagnostic and prognostic significance [ 8 , 9 ]. The prognostic value of ventricular strain has been demonstrated in other cardiac diseases [ 10 , 11 , 12 ] and myocarditis [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis

Chen

Zhao

Zhang

et al. 2023

JCM

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To assess the variation in left atrial (LA) and biventricular strain and its prognostic value in the course of suspected myocarditis, this retrospective study included 55 patients with clinically suspected myocarditis who underwent cardiac magnetic resonance (CMR) examinations at baseline and follow-up periods. Cine images were used for feature tracking analysis. Paired Student’s t test, McNemar’s test, and Cox proportional hazard regression were used for statistical analysis. The LA total emptying fraction was the only functional index that showed a statistically significant improvement. The initial LA peak’s late negative strain rate (SRa) was the only parameter with a significant predictive power of major adverse cardiac events under univariable (hazard ratio [HR] 2.396, 95% confidence interval [CI] 1.044–5.498, p = 0.039) and multivariable Cox survival analysis when adjusted by LA strain parameters (HR 5.072, 95% CI 1.478–17.404, p = 0.010), LA strain and functional parameters (HR 7.197, 95% CI 1.679–30.846, p = 0.008), and LA and biventricular strain and functional parameters (HR 10.389, 95% CI 2.250–47.977, p = 0.003). Thus, our findings indicate that CMR strain is useful for monitoring LA and ventricular function in suspected myocarditis, that LA function may recover preceding ventricular function changes, and that LA strain may serve as an incremental tool to predict adverse outcomes.

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State-of-the-art myocardial strain by CMR feature tracking: clinical applications and future perspectives

Cited by 69 publications

References 100 publications

The Role of MR Assessments of Cardiac Morphology, Function, and Tissue Characteristics on Exercise Capacity in Well‐Functioning Older Adults

The Role of MR Assessments of Cardiac Morphology, Function, and Tissue Characteristics on Exercise Capacity in Well‐Functioning Older Adults

Early Cardiac Magnetic Resonance-derived Cardiac Strain as a Predictor of Adverse Events and Ventricular Remodeling in Patients with Reperfused STEMI: A Two-center Cohort Study

Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis

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