Starting the journey: Understanding the roles of complement proteins in liver diseases through mendelian randomization

Rezaee-Zavareh, Mohammad Saeid; Kim, Naomy; Yang, Ju Dong

doi:10.3350/cmh.2024.0116

Cited by 3 publications

(2 citation statements)

References 22 publications

(30 reference statements)

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“…Recent studies have highlighted the significant public health burden posed by these metabolic liver diseases. The global prevalence of MASLD is estimated to be around 30%, with more than a 50% increase from the 1990s to the 2010s, and its variations are based on geographic region, ethnicity, and the diagnostic criteria used [3,4]. MetALD, although less well-defined in the literature, is increasingly implicating a requirement for the specific management of the disease and future prospective studies for better defining its natural history [5].…”

Section: Introductionmentioning

confidence: 99%

Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment

Yang,

Chang,

Jeong

et al. 2024

Nutrients

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Coffee consumption is globally widespread and has become a lifestyle habit. This study investigated coffee consumption and liver-related survival in a large cohort of 455,870 individuals with UK biobank, categorized into without steatosis, metabolic dysfunction-associated steatotic liver disease (MASLD), and MASLD and increased alcohol intake (MetALD). Inverse probability of treatment weighting (IPTW) adjusted for confounding variables was used, followed by Kaplan–Meier analysis. Moderate coffee consumption (1–2 cups per day) was associated with lower all-cause mortality across the entire cohort, without the steatosis, MASLD (p < 0.0001), and MetALD cohorts (p = 0.0047 for pre-IPTW, p = 0.027 for post-IPTW). Before IPTW adjustment, consuming one or more cups of coffee per day appeared to significantly reduce liver-related mortality in the overall (p = 0.015) and MASLD cohorts (p = 0.011). However, post-IPTW application, no significant differences in liver-related mortality were observed between the coffee intake groups (p = 0.778, 0.319, 0.564, 0.238 for each group). While increased coffee consumption initially seemed to reduce liver-related mortality, after IPTW adjustment, only all-cause mortality significantly decreased (p < 0.0001 and p = 0.027). These findings suggest that previous studies might have overestimated the favorable effect of coffee intake on chronic liver disease due to confounding factors.

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Section: Introductionmentioning

confidence: 99%

Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment

Yang,

Chang,

Jeong

et al. 2024

Nutrients

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“…Grounded in the principles of Mendelian inheritance, MR's causal inference is crucial for the identification and repurposing of therapeutic agents 16 . MR has emerged as a powerful investigative tool in HCC research, enabling the elucidation of causal relationships within this field 17 . Previous studies employing MR have provided significant insights into the determinants of HCC susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Causal relationship between immune cells and hepatocellular carcinoma: a Mendelian randomisation study

Tang,

Zhang,

Jiang

et al. 2024

J. Cancer

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Impact of Physical Activity on Overall Survival and Liver Cirrhosis Incidence in Steatotic Liver Disease: Insights from a Large Cohort Study Using Inverse Probability of Treatment Weighting

Yang,

Chung,

Ryu

2024

Nutrients

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Physical activity is a cornerstone of a healthy lifestyle, with benefits in managing chronic diseases. This study investigates the relationship between physical activity and liver-related outcomes with or without steatotic liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD) and MASLD and increased alcohol intake (MetALD). The primary outcomes of interest were overall survival in the entire population, individuals without steatotic liver disease, patients with MASLD, and those with MetALD. The secondary outcomes included the incidence of liver cirrhosis. Participants were categorized based on physical activity frequency and Kaplan–Meier survival curves and Cox proportional hazards models were used for analysis. Higher physical activity was associated with significantly better survival in the overall cohort and MASLD cohort before and after inverse probability of treatment weighting (IPTW). In participants without steatotic liver disease and the MetALD cohort, higher physical activity showed significant survival improvement after IPTW. For the incidence of liver cirrhosis, higher physical activity showed significant associations before IPTW in the overall cohort and MASLD cohort, but these associations were not significant after IPTW. Marginal significance was observed in the MetALD cohort before and after IPTW. In conclusion. promoting physical activity may be key in improving liver-related outcomes.

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Starting the journey: Understanding the roles of complement proteins in liver diseases through mendelian randomization

Cited by 3 publications

References 22 publications

Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment

Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment

Causal relationship between immune cells and hepatocellular carcinoma: a Mendelian randomisation study

Impact of Physical Activity on Overall Survival and Liver Cirrhosis Incidence in Steatotic Liver Disease: Insights from a Large Cohort Study Using Inverse Probability of Treatment Weighting

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