Staphylococcus epidermidis Endophthalmitis Complicating Intravitreal Antiviral Therapy of Cytomegalovirus Retinitis

Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

“…The half-life of ganciclovir in vitreous fluid following intravitreal administration is about 13 hours [29] and, thus, frequent injections are necessary to maintain the therapeutic levels. This fact limits its use because these injections are associated with a risk of cataract development, retinal detachment and endophtalmitis [30,31].…”

Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

“…The half-life of ganciclovir in vitreous fluid following intravitreal administration is about 13 hours [29] and, thus, frequent injections are necessary to maintain the therapeutic levels. This fact limits its use because these injections are associated with a risk of cataract development, retinal detachment and endophtalmitis [30,31].…”

Ring-Opening Polymerization of ε-Caprolactone Initiated by Ganciclovir (GCV) for the Preparation of GCV-Tagged Polymeric Micelles

“…GCV however is only slightly water soluble, and as a result, has poor oral and ocular bioavailability. Therefore, it needs to be administered intravenously; however, due to its short biological half-life, frequent dosing is required, which may increase the risk of systemic toxicity and discomfort to the patient [ 1 , 2 , 3 , 4 ]. To address the aforementioned problems, several drug delivery systems have been developed for GCV [ 5 , 6 , 7 , 8 , 9 ].…”

Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

“…The half-life of ganciclovir in vitreous fluid following intravitreal administration is about 13 hours [29] and, thus, frequent injections are necessary to maintain the therapeutic levels. This fact limits its use because these injections are associated with a risk of cataract development, retinal detachment and endophtalmitis [30,31].…”

Ring-Opening Polymerization of ε-Caprolactone Initiated by Ganciclovir (GCV) for the Preparation of GCV-Tagged Polymeric Micelles

“…GCV however is only slightly water soluble, and as a result, has poor oral and ocular bioavailability. Therefore, it needs to be administered intravenously; however, due to its short biological half-life, frequent dosing is required, which may increase the risk of systemic toxicity and discomfort to the patient [ 1 , 2 , 3 , 4 ]. To address the aforementioned problems, several drug delivery systems have been developed for GCV [ 5 , 6 , 7 , 8 , 9 ].…”

Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

“…The half-life of ganciclovir in vitreous fluid following intravitreal administration is about 13 hours [29] and, thus, frequent injections are necessary to maintain the therapeutic levels. This fact limits its use because these injections are associated with a risk of cataract development, retinal detachment and endophtalmitis [30,31].…”

Ring-Opening Polymerization of ε-Caprolactone Initiated by Ganciclovir (GCV) for the Preparation of GCV-Tagged Polymeric Micelles

“…GCV however is only slightly water soluble, and as a result, has poor oral and ocular bioavailability. Therefore, it needs to be administered intravenously; however, due to its short biological half-life, frequent dosing is required, which may increase the risk of systemic toxicity and discomfort to the patient [ 1 , 2 , 3 , 4 ]. To address the aforementioned problems, several drug delivery systems have been developed for GCV [ 5 , 6 , 7 , 8 , 9 ].…”