2011
DOI: 10.1099/jmm.0.031922-0
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Abstract: Staphylococcus epidermidis is an opportunistic pathogen and, due to its ability to establish biofilms, is a leading causative agent of indwelling medical device-associated infection. The presence of high amounts of dormant bacteria is a hallmark of biofilms, making them more tolerant to antimicrobials and to the host immune response. We observed that S. epidermidis biofilms grown in excess glucose accumulated high amounts of viable but non-culturable (VBNC) bacteria, as assessed by their low ratio of culturabl… Show more

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Cited by 56 publications
(72 citation statements)
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“…For example, C. jejuni , a food-borne bacterium, forms VBNC cells in biofilms where biocide resistance is increased (Newell and Fearnley, 2003). S. epidermidis in biofilms was found to enter a VBNC state when grown in media with an excess of glucose (Cerca et al, 2011). Interestingly, these VBNC cells induced a lower production of the cytokines TNF-α and IL-6, and replicated in macrophages to a lesser extent than their culturable counterparts leading to lower macrophage death.…”
Section: Significancesmentioning
confidence: 99%
“…For example, C. jejuni , a food-borne bacterium, forms VBNC cells in biofilms where biocide resistance is increased (Newell and Fearnley, 2003). S. epidermidis in biofilms was found to enter a VBNC state when grown in media with an excess of glucose (Cerca et al, 2011). Interestingly, these VBNC cells induced a lower production of the cytokines TNF-α and IL-6, and replicated in macrophages to a lesser extent than their culturable counterparts leading to lower macrophage death.…”
Section: Significancesmentioning
confidence: 99%
“…Remarkably, part of the biofilm population of pathogenic bacteria persists in a VBNC state and escapes detection by the existing methods. The presence of Staphylococcus epidermidis in the VBNC state leads to the formation of biofilms, which are not only tolerant to many antimicrobials, but also contribute to immune evasion (84). …”
Section: Public Health and Environmental Investigationsmentioning
confidence: 99%
“…Increased macrophage cytotoxicity was also observed in the presence of S. aureus biofilms. S. epidermidis biofilms containing increased levels of dormant bacteria led to decreased activation of murine macrophages and less secretion of inflammatory cytokines, suggesting that biofilms aid in immune evasion [109]. …”
Section: The Impact Of Staphylococcal Biofilms On Immune Responses Anmentioning
confidence: 99%