Infectious Disease Clinics of North America volume 23, issue 1, P153-171 2009 DOI: 10.1016/j.idc.2008.10.005 View full text
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Adam C. Schaffer, Jean C. Lee

Abstract: Staphylococcus aureus is an important pathogen in the hospital and in the community, and it is increasingly resistant to multiple antibiotics. A nonantimicrobial approach to controlling S aureus is needed. The most extensively tested vaccine against S aureus, which is a capsular polysaccharide-based vaccine known as StaphVAX, showed promise in an initial phase 3 trial, but was found to be ineffective in a confirmatory trial, leading to its development being halted. Likewise, a human IgG preparation known as IN…

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