Staphylococcal scalded skin syndrome in an adult

Rothenberg, R.

doi:10.1001/archderm.108.3.408

Cited by 15 publications

(9 citation statements)

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“…[1974] demonstrated that a staphylococcal TEN could be produced in adult mice pretreated with systematically injected corticosteroids for 3 weeks. Rothenberg et al [1973] related another case report of an infected hematoma followed by SSSS. In addition, their patient, a 64-year-old male, developed an osteomyelitis of the pelvic bone and a septicemia, both caused by S. aureus phage group II.…”

Section: Commentmentioning

confidence: 92%

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Staphylococcal Scalded Skin Syndrome in an Adult

et al. 1975

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The staphylococcal form of toxic epidermal necrolysis or staphylococcal scalded skin syndrome (SSSS) is exceptionally seen in an adult patient. We report a case of SSSS in a 21-year-old male who suffered from a fulminant pneumopathia due to a phage group II Staphylococcus aureus. The onset of that clinical picture in an adult patient is unusual and could be due to a deficient immunity, as previous case reports have emphasized. Unfortunately, the sudden death of our patient did not allow us to investigate his immunological defences.

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Section: Commentmentioning

confidence: 92%

“…This pathology is rarely encountered in the adult; only six documented cases have been reported, to the best of our knowledge [Birke et a/., 1971; Levine and N o r d e n , 1972; Rothenberg et a!., 1973; H aw ley and A ro n so n . 1973; R eid et a !., 1974; E pstein et a!., 1974], and probably another case report in the original paper of L yell in 1956.…”

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confidence: 99%

Staphylococcal Scalded Skin Syndrome in an Adult

et al. 1975

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“…This age predilection is so characteristic that, previously, neonatal age was considered a prerequisite for the diagnosis (Ritter von Rittershain, 1975;Tachau, 1934). Today, cases are recognized in childhood and, rarely, even in adults (Epstein, Flynn & Davis, 1974;Hawley & Aronson, 1973;Levine & Norden, 1972;Reid, Weston & Humbert, 1974;Rothenberg et al:, 1973). Yet, analysis of representative recent series indicates that no shift of the peak incidence has taken place (Eliasj Fritsch & Epstein, 1976).…”

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confidence: 99%

The fate of Staphylococcal exfoliatin in newborn and adult mice*

1976

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The distribution and excretion of the staphylococcal exfoliatin was investigated following in vivo administration of highly purified 125I-labelled exfoliatin fractions to adult and newborn mice. Adult mice excrete approximately one-third of a test dose by 3 hours as compared to a fifteenth of a test dose excreted by newborn mice. Accordingly, blood tracer radioactivity reaches a relatively higher peak and shows a slower decline in newborns than in adults. The urine of adult mice contains considerable biologically active exfoliating material. Both nephrectomized and carbon tetrachloride-poisoned adult mice injected with exfoliatin develop generalized exfoliation whereas comparable doses in untreated controls have no effect. On the other hand, subtotal hepatectomy, followed by injection of exfoliatin, does not lead to exfoliation. We conclude that renal immaturity is a critical factor responsible for the susceptibility of neonates to generalized staphylococcal scalded skin syndrome.

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“…Moreover, the phage group 2 S. aureus produced exfoliative toxins as previously described [1], Few cases of SSSS have been reported in patients with staphylococcal abscess but without predisposing factors [3,4], Indeed, in adults. SSSS is usually associated with renal insufficiency and/or immunosuppression.…”

Section: Discussionmentioning

confidence: 87%