Stanozolol-induced bland cholestasis

Ampuero, Javier; García, Emilio Suárez; Lorenzo, Marina Millán; Calle, R; Ferrero, Paula Gallego; Romero‐Gómez, Manuel

doi:10.1016/j.gastrohep.2013.09.009

Cited by 12 publications

(14 citation statements)

References 9 publications

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“…This biochemical pattern is probably secondary to dysfunction in the canalicular efflux system of bile salts, bilirubin and organic anions 12 , usually associated to drugs. Relative hypoxia may be the driver mechanism of this canalicular defect in patients with hyperthyroidism 13 .…”

Section: Discussionmentioning

confidence: 99%

Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case

et al. 2020

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Hyperthyroidism can induce elevation in several liver function tests including aminotransferases, alkaline phosphatases and, less frequently, serum bilirubin. These alterations are usually mild and asymptomatic. We report a 26 year-old male presenting with palpitations, progressive jaundice, choluria and generalized itching. Laboratory tests were compatible with hyperthyroidism and a mild elevation of bilirubin, alkaline phosphatases and gamma glutamyl transpeptidase. A liver biopsy showed portal hepatitis with canalicular cholestasis. The patient was treated temporarily with glucocorticoids, cholestyramine and betablockade. Thereafter, he was treated with radioactive iodine, after which serum bilirubin decreased steadily until normalization in ten weeks.

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Section: Discussionmentioning

confidence: 99%

Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case

et al. 2020

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“…The overproduction of ROS causes oxidative stress, damages polyunsaturated fatty acids of the cell membranes by altering their initial chemical conformation ( Dornelles et al, 2017 ). In humans, severe hepatotoxicity and cholestasis because of the stanozolol abuse have been reported ( Ampuero et al, 2014 ; Segal, Cooper, & Bolognia, 2000 ). Few cases of severe dilated cardiomyopathy were reported in young patients associated with anabolic steroid abuse ( Ferrera, Putnam, & Verdile, 1997 ; Nieminen et al, 1996 ).…”

Section: Discussionmentioning

confidence: 99%

Performance-Enhancing Drugs Abuse Caused Cardiomyopathy and Acute Hepatic Injury in a Young Bodybuilder

Adhikari

Gao

et al. 2018

Am J Mens Health

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A number of performance-enhancing drugs (PEDs) are used illicitly to improve muscle strength by the bodybuilders. The misuse of these drugs is associated with serious adverse effects to different organs. A previously healthy 22-year-old male bodybuilder after taking stanozolol, clenbuterol, and triiodothyronine for 10 days presented to the hospital with symptoms of icteric sclera, progressive dyspnea, intermittent cough, and bloody sputum. He was diagnosed with dilated cardiomyopathy and acute hepatic injury. Rapidly progressive dilated cardiomyopathy and acute hepatic injury among bodybuilders in such a short period of time have not been reported. People using these drugs must monitor liver and cardiac functions regularly, and they should discontinue using PEDs after diagnosis of liver or cardiac abnormalities. Physicians should always consider the possibility of the PED abuse in the context of a young athlete suffering cardiomyopathy or hepatic injury.

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“…Acute cholestatic injury is the characteristic injury pattern of the anabolic steroids and oral contraceptives 32 . Such injury from oral contraceptives has become less common as the doses of estrogens and progestins have been reduced in more recent formulations, but anabolic steroid jaundice remains a clinical problem, particularly among young men using body building supplements 33–35 . These supplements can be easily obtained without a prescription and often contain steroid derivatives 36 .…”

Section: Characteristic Patterns Of Injurymentioning

confidence: 99%

Drug-induced Liver Injury

Kleiner

2017

Gastroenterology Clinics of North America

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Biopsies of suspected drug-induced liver injury pose a particular challenge to the pathologist that requires a careful and systematic approach. The initial evaluation should be as objective as possible, setting aside consideration of the medical history. Histological changes are catalogued with attention to the hepatic architecture, noting the intensity and character of inflammation, cholestasis, apoptosis and necrosis. Bile ducts, portal vessels, hepatocytes, sinusoidal lining cells and vessels are each examined for evidence of injury. The assessment culminates with the determination of the overall pattern of injury. Armed with this information, the pathologist correlates the findings with the patient’s medical and pharmacological history. Drug induced liver injury is always a diagnosis of exclusion, so the emphasis should be on identification of potential competing causes of injury. If alternate etiologies of injury can be eliminated, the histological injury pattern can be compared to the known patterns of injury of suspect medications. The histological changes can also shed light on the potential mechanism of injury in situations where the suspect agents are new and do not yet have reports of hepatotoxicity. The pathological findings, the histological differential diagnosis and expert interpretation are part of a complete biopsy assessment and provide information that is of greatest value in patient management.

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Stanozolol-induced bland cholestasis

Cited by 12 publications

References 9 publications

Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case

Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case

Performance-Enhancing Drugs Abuse Caused Cardiomyopathy and Acute Hepatic Injury in a Young Bodybuilder

Drug-induced Liver Injury

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Stanozolol-induced bland cholestasis

Cited by 12 publications

References 9 publications

Cholestasis secondary to hyperthyroidism in Graves&#8217; disease. Report of one case

Cholestasis secondary to hyperthyroidism in Graves&#8217; disease. Report of one case

Performance-Enhancing Drugs Abuse Caused Cardiomyopathy and Acute Hepatic Injury in a Young Bodybuilder

Drug-induced Liver Injury

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Product

Resources

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Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case

Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case