Standardized Full-Field Electroretinography

Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography

“…In contrast, b-wave sensitivity (log K ) was generally independent of age. These results are consistent with those obtained from human subjects 3 , which also showed considerable loss of V max from age 20 to 68, with minimal increase in K .…”

Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography

“…In contrast, b-wave sensitivity (log K ) was generally independent of age. These results are consistent with those obtained from human subjects 3 , which also showed considerable loss of V max from age 20 to 68, with minimal increase in K .…”

Intensity response function of the photopic negative response (PhNR): effect of age and test–retest reliability

“…Since previous studies have reported significant age effects on the photopic b-wave amplitude [62,64], we were surprised on the finding in our study that the V max of the bwave did not show statistically significant changes with age. This could be partly because we were estimating the saturated amplitudes of the photopic b-waves while the earlier studies measured amplitudes at a fixed flash intensity, most likely in the linear portion of the intensity response curve.…”

Electroretinography and Gene Expression Measures Implicate Phototransduction and Metabolic Shifts in Chick Myopia and Hyperopia Models

“…Indeed, the absence of a significant effect of induction time on ERG wave amplitudes in the present study suggests that axial length artefacts may have a minimal effect on the gfERG in the small chick eye, consistent with previous multifocal ERG reports in humans [58]. We did identify a decrease in a-wave and b-wave implicit time with induction time independent of lens defocus, consistent with investigations of ERG maturation in humans [59,60] and chicks [61].…”

Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography

“…In contrast, b-wave sensitivity (log K ) was generally independent of age. These results are consistent with those obtained from human subjects 3 , which also showed considerable loss of V max from age 20 to 68, with minimal increase in K .…”

Intensity response function of the photopic negative response (PhNR): effect of age and test–retest reliability

“…Since previous studies have reported significant age effects on the photopic b-wave amplitude [62,64], we were surprised on the finding in our study that the V max of the bwave did not show statistically significant changes with age. This could be partly because we were estimating the saturated amplitudes of the photopic b-waves while the earlier studies measured amplitudes at a fixed flash intensity, most likely in the linear portion of the intensity response curve.…”

Electroretinography and Gene Expression Measures Implicate Phototransduction and Metabolic Shifts in Chick Myopia and Hyperopia Models

“…Indeed, the absence of a significant effect of induction time on ERG wave amplitudes in the present study suggests that axial length artefacts may have a minimal effect on the gfERG in the small chick eye, consistent with previous multifocal ERG reports in humans [58]. We did identify a decrease in a-wave and b-wave implicit time with induction time independent of lens defocus, consistent with investigations of ERG maturation in humans [59,60] and chicks [61].…”

Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography

“…In contrast, b-wave sensitivity (log K ) was generally independent of age. These results are consistent with those obtained from human subjects 3 , which also showed considerable loss of V max from age 20 to 68, with minimal increase in K .…”

Intensity response function of the photopic negative response (PhNR): effect of age and test–retest reliability

“…Since previous studies have reported significant age effects on the photopic b-wave amplitude [62,64], we were surprised on the finding in our study that the V max of the bwave did not show statistically significant changes with age. This could be partly because we were estimating the saturated amplitudes of the photopic b-waves while the earlier studies measured amplitudes at a fixed flash intensity, most likely in the linear portion of the intensity response curve.…”

Electroretinography and Gene Expression Measures Implicate Phototransduction and Metabolic Shifts in Chick Myopia and Hyperopia Models

“…Indeed, the absence of a significant effect of induction time on ERG wave amplitudes in the present study suggests that axial length artefacts may have a minimal effect on the gfERG in the small chick eye, consistent with previous multifocal ERG reports in humans [58]. We did identify a decrease in a-wave and b-wave implicit time with induction time independent of lens defocus, consistent with investigations of ERG maturation in humans [59,60] and chicks [61].…”