Standardization of an antihemorrhagic potency test of antivenoms prepared from two different Agkistrodon halys venoms

Abstract

ABSTRACT:To establish Korea National Standards for venoms and antivenoms, it is necessary to have standardized assay methods. In this study, we standardized a method to evaluate the antihemorrhagic potency of two horse-derived antivenoms using rabbit intracutaneous injection. We expressed the capability of these antivenoms to neutralize the hemorrhagic activities triggered by the venoms of