Standardisation of the single-breath determination of carbon monoxide uptake in the lung

MacIntyre, Neil R.; Crapo, Robert O.; Viegi, Giovanni; Johnson, Douglas C.; Grinten, C.P.M. van der; Brusasco, Vito; Burgos, Felip; Casaburi, Richard; Coates, Allan L.; Enright, P.; Gustafsson, Per; Hankinson, John; Jensen, Robert L.; McKay, Roy T.; Miller, Martin; Navajas, Daniel; Pedersen, Ole F.; Pellegrino, Riccardo; Wanger, Jack

doi:10.1183/09031936.05.00034905

Cited by 1,975 publications

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“…Results were expressed as percentage of normal for gender, age, and height (percent predicted). DLCO was measured by single breath test24 (2010 Ganshorn, Medizin Electronic GmbH Industries, Trasse 6‐8, 97618. Software version LF 8).…”

Section: Methodsmentioning

confidence: 99%

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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Background and AimUlcerative colitis (UC) patients have several extraintestinal and systemic manifestations. As studies on the frequency and predictors of pulmonary involvement in patients with UC are inconsistent, we undertook this prospective study.MethodsEighty‐seven patients with UC (in remission 49, 56.3%, active disease 38, 43.6%, median age: 40 years, range: 16–66, 55, 62.2% males) and 50 healthy controls (median age: 38 years, range: 14–69, 34, 68% males) underwent pulmonary function tests (PFTs) including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), Tiffeneau value (FEV1/FVC), mid‐expiratory flow rate, and diffusion lung capacity for carbon monoxide with spirometer.ResultsSubjects with UC and control were comparable in age and gender. PFT was abnormal in 24 (27.5%) patients (active disease 15/38, 39.4%, remission 9/49, 18.4%) and 1 (2%) control (P < 0.005). Of the 24 patients with abnormal PFT, small airway, restrictive, and obstructive defects were detected in 12 (50%), 11 (45.8%), and 1 (4.2%) patients, respectively. Patients with abnormal PFT more often had active disease (15/24, 62.5% vs 23/63, 36.5%; P = 0.03). No relation of PFT abnormalities was found with age, sex, duration of disease, body mass index, serum albumin, and hemoglobin levels, and other extraintestinal manifestation (arthritis/arthralgia) and drugs used to treat UC.ConclusionUC patients with active disease have abnormal pulmonary functions with predominant involvement of small airways. Active UC was more often associated with abnormal PFT than the disease in remission.

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Section: Methodsmentioning

confidence: 99%

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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“…We used DL CO ϫ 1.23 as a surrogate for the diffusing capacity for oxygen (17). Hemoglobin concentrations were measured from venous blood samples, and Vc and DL CO values were corrected accordingly for an inspired PO2 of 150 mmHg and for standard concentrations of hemoglobin of 14.6 g/dl for men and 13.4 g/dl for women (29). The percent predicted values were calculated using previously reported equations (3).…”

Section: Methodsmentioning

confidence: 99%

Improvement in lung diffusion by endothelin A receptor blockade at high altitude

Bisschop

Martinot

Leurquin‐Sterk³

et al. 2012

Journal of Applied Physiology

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de Bisschop C, Martinot J, Leurquin-Sterk G, Faoro V, Guénard H, Naeije R. Improvement in lung diffusion by endothelin A receptor blockade at high altitude. J Appl Physiol 112: 20 -25, 2012. First published October 6, 2011 doi:10.1152/japplphysiol.00670.2011.-Lung diffusing capacity has been reported variably in high-altitude newcomers and may be in relation to different pulmonary vascular resistance (PVR). Twenty-two healthy volunteers were investigated at sea level and at 5,050 m before and after random double-blind intake of the endothelin A receptor blocker sitaxsentan (100 mg/day) vs. a placebo during 1 wk. PVR was estimated by Doppler echocardiography, and exercise capacity by maximal oxygen uptake (V O2 max). The diffusing capacities for nitric oxide (DLNO) and carbon monoxide (DLCO) were measured using a single-breath method before and 30 min after maximal exercise. The membrane component of DLCO (Dm) and capillary volume (Vc) was calculated with corrections for hemoglobin, alveolar volume, and barometric pressure. Altitude exposure was associated with unchanged DLCO, DLNO, and Dm but a slight decrease in Vc. Exercise at altitude decreased DLNO and Dm. Sitaxsentan intake improved V O2 max together with an increase in resting and postexercise DLNO and Dm. Sitaxsentan-induced decrease in PVR was inversely correlated to DLNO. Both DLCO and DLNO were correlated to V O2 max at sea level (r ϭ 0.41-0.42, P Ͻ 0.1) and more so at altitude (r ϭ 0.56 -0.59, P Ͻ 0.05). Pharmacological pulmonary vasodilation improves the membrane component of lung diffusion in high-altitude newcomers, which may contribute to exercise capacity. altitude; hypoxia; lung diffusion; gas exchange; exercise capacity; pulmonary vascular resistance; pulmonary capillary pressure; pulmonary hypertension BOTH THE MEMBRANE AND THE capillary components of lung diffusing capacity have been shown to be increased in highaltitude residents (10,13,15,25). Increased lung diffusing capacity at high altitude allows for the preservation of gas exchange in the presence of a decreased ventilatory response at exercise (15). High-altitude newcomers do not benefit from this adaptation (10,15,25) and, accordingly, depend on increased ventilation to maintain pulmonary gas exchange (15,45).Previous studies on lung diffusing capacity at high altitudes calculated the membrane and capillary components of alveolocapillary transfer of carbon monoxide (CO) using measurements at ambient air and increased inspired PO 2 (10,13,15,25). This approach rests on the PO 2 dependence of , the blood's specific transfer conductance of CO, in the Roughton and Forster equation, which states that 1/DL CO ϭ 1/Dm ϩ 1/ Vc where DL CO is the diffusing capacity of the lung for CO, Dm its membrane component, and Vc the capillary blood volume (37). Thus changing as by increasing or decreasing inspired PO 2 allows for the calculation of Dm and Vc from a simple system of two equations with two unknowns. However, changing inspired PO 2 might also change pulmonary vascular tone, cardiac output, ...

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“…Best of three satisfactory readings was taken for analysis. The technique was validated in our laboratory and the prediction equations for normal Indian subjects had been derived and reported previously [15,16]. Normal values are based upon age, height, ethnicity, and sex.…”

Section: Measurement Of Dlcomentioning

confidence: 99%

“…Normal values are based upon age, height, ethnicity, and sex. A value is usually considered abnormal if it is less than 80% of predicted value [15,16].…”

Section: Measurement Of Dlcomentioning

confidence: 99%

Assessment of Lung Function by Spirometry and Diffusion Study and Effect of Glycemic Control on Pulmonary Function in Type 2 Diabetes Mellitus Patients of the Eastern India

Zaman¹

2014

JCDR

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Introduction: There are so many complications involving eyes, kidneys, lungs and nerves associated with diabetes. But, pulmonary complications are poorly characterized among eastern Indian diabetic populations. Aims and Objectives:To assess pulmonary function in patients with type 2 diabetes mellitus. To find out correlation of the pulmonary functions test variables with Glycemic control. Materials and Methods:Total of 60 type 2 diabetes patient of age between 35-55 y and same number of age and sex matched apparently healthy control individual were included in the present study. All subjects were evaluated for PFT by flow sensitive spirometer (RMS HELIOS-401), the spirometric parameters were measured as a percentage of predicted and DLCO (by single breath technique). HBA1c of all cases were measured and they were grouped according to HBA1c level (Group-a =>7%, Group-b =6%-7%, Group-c =<6%).Results: Significant differences in the spirometric parameters (FVC, FEV1/FVC) and diffusion capacity (DLCO% and DL/VA%) existed between cases and controls. There was a significant decrease in FVC, DLCO and DL/VA and significant increase in FEV1/FVC in that groups having HBA1c level >7% than the other groups. FEV1, FVC, DLCO, and DL/VA were negatively correlated with HbA1c where as FEV1/FVC has positive association with HbA1c. Conclusion:Significant deterioration of lung function and diffusing capacity was observed in type 2 diabetes patients with poor glycemic control.India [6][7][8][9]. The wide range of geographical and climatic conditions in a large country such as India may be associated with regional differences in lung function. Pulmonary complications are poorly characterized among eastern Indian diabetic populations. On this background this study was conducted on eastern India population for assessment of lung function in type 2 diabetes mellitus. AIMS AND OBjeCTIveS1. To assess pulmonary function in patients with type 2 diabetes mellitus.2. To find out correlation of the pulmonary functions test variables with Glycemic control. MATeRIAlS AND MeThODSEighty type 2 DM cases were randomly selected from patients attending Diabetic Following patients were excluded from the study: Smokers; history of respiratory diseases such as asthma, COPD, tuberculosis,

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Standardisation of the single-breath determination of carbon monoxide uptake in the lung

Cited by 1,975 publications

References 96 publications

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

Improvement in lung diffusion by endothelin A receptor blockade at high altitude

Assessment of Lung Function by Spirometry and Diffusion Study and Effect of Glycemic Control on Pulmonary Function in Type 2 Diabetes Mellitus Patients of the Eastern India

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