Staging of prostate cancer: results of Radiology Diagnostic Oncology Group project comparison of three MR imaging techniques.

Tempany, Clare M.; Zhou, Xiao Hua; Zerhouni, Elias A.; Rifkin, Matthew D.; Quint, Leslie E.; Piccoli, Catherine W.; Ellis, James H.; McNeil, Barbara J.

doi:10.1148/radiology.192.1.8208963

Cited by 236 publications

(114 citation statements)

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“…A wide range has been reported for the accuracy of staging by CT (40±92%) [1±5] and for conventional and contrast material-enhanced MRI (50± 96%) [1±8]. Over the past decade, MRI with an endorectal surface coil has been used to improve the accuracy of the preoperative staging of prostatic carcinoma [9,10]. We have used MRI with an endorectal surface coil to stage bladder tumours and noted a markedly enhanced layer within the bladder wall after administering Gd-DTPA.…”

Section: Introductionmentioning

confidence: 99%

A new staging criterion for bladder carcinoma using gadolinium‐enhanced magnetic resonance imaging with an endorectal surface coil: a comparison with ultrasonography

Hayashi¹,

Tochigi

Shiraishi³

et al. 2000

BJU International

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Objective To evaluate the accuracy of a new staging criterion, submucosal linear enhancement (SLE) on gadolinium-diethylenetriamine-pentaacetic acidenhanced T1-weighted magnetic resonance imaging (MRI) using an endorectal surface coil (endorectal enhanced MRI), and to compare the accuracy of this method with that of transurethral ultrasonography (TUUS). Patients and methods The study included 71 patients with bladder tumours (63 men and eight women, mean age 65.5 years, range 31±85). The SLE coincided with abundant submucosal vascular beds, as reported in a previous study. When the SLE beneath the tumour maintained continuity, the tumour was diagnosed as super®cial (fT1), but if the SLE was interrupted by the tumour, the disease was considered invasive (oT2a). Super®cial muscle invasion (less than half the muscle layer) and deep muscle invasion (more than half the muscle layer) were classi®ed as T2a and T2b, respectively. When the tumour formed an extravesical mass, the tumour was classi®ed as T3b. Results The staging accuracy for bladder tumours using SLE on endorectal-enhanced MRI or TUUS was 83% and 60%, respectively (P<0.01). Using the SLE, muscle invasion of bladder tumour was diagnosed with an accuracy of 87%, a sensitivity of 91% and a speci®city of 87%; this was signi®cantly better than with TUUS (P<0.01). Conclusion The criterion of SLE on Gd-DTPA enhanced T1-weighted MRI using an endorectal surface coil is useful for staging bladder tumour, and the staging accuracy is signi®cantly better than with TUUS.

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Section: Introductionmentioning

confidence: 99%

A new staging criterion for bladder carcinoma using gadolinium‐enhanced magnetic resonance imaging with an endorectal surface coil: a comparison with ultrasonography

Hayashi¹,

Tochigi

Shiraishi³

et al. 2000

BJU International

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“…34,39,40 The detection of seminal vesicle involvement has been demonstrated in several studies that examined retrospectively the results of radical prostatectomy in patients with clinically con®ned disease. In a study by Terris et al the seminal vesicle positive rate was 13.8%.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided seminal vesicle biopsies in prostate cancer

Wymenga

Duisterwinkel

Groenier

et al. 2000

Prostate Cancer Prostatic Dis

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Invasion of prostatic adenocarcinoma into the seminal vesicles (SV) is generally accepted as an index of poor prognosis. The pre-operative identi®cation of SV invasion is an important element in staging since it may alter subsequent treatment decisions. We studied the possibility of diagnosing SV invasion with two biopsies from the junction between the prostate and seminal vesicles. Also we studied the correlation of several prognostic factors with the risk of clinical stage T 1,2,3 prostate cancer patients of having cancer growth into the seminal vesicles.Consecutive patients referred for transrectal ultrasound (TRUS) and biopsy because of clinical suspicion of prostate cancer were examined. This staging procedure was evaluated in patients who underwent a pelvic lymphadenectomy and radical retropubic prostatectomy (RRP).In 83 out of 138 patients prostate cancer was detected whereas 55 patients had benign disease. In 44% of prostate cancer patients a positive SV biopsy was found. The accuracy of the biopsies adjacent to the junction of the SV and the prostate was 91%. The best predictors for SV invasion were tumor grade of the biopsy sample (P`0.001), serum prostate-speci®c antigen (PSA) (P`0.0005), PSA density (P`0.0005) and clinical stage (P`0.0005). No signi®cance was found in the relation to seminal vesicle involvement with free/total (f/t) PSA ratio (P 0.588) for the prostate cancer group (SV and SV 7 ).In a receiver operating characteristic curves analysis, PSA density was signi®cantly more accurate for prediction of SV invasion than PSA or f/t PSA ratio. In ®ve prostatectomized patients (and negative SV biopsy) no SV invasion was found in the ®nal pathologic examination either.SV biopsy at the junction of the SV and prostate is accurate for staging with high ef®cacy and low morbidity. To predict SV invasion in prostate cancer patients, PSA density was more accurate than PSA or f/t PSA ratio. The determination of the f/t PSA ratio in patients with low and intermediate PSA levels (eg`15 mg/L) is not useful to estimation of the risk of seminal vesicle involvement. The combination of serum PSA concentration, PSA density, tumor grade from the biopsy specimens ad clinical stage provides the best prediction of SV invasion. These parameters are identical to the conventional predictors of pathology after RRP. SV biopsies may provide additional information; if one or both basal biopsies are positive, a clinical T 1,2 disease is altered to T 3 . Hence SV biopsy is useful for selection of patients who might obtain good results from RRP for prostate cancer. Prostate Cancer and Prostatic Diseases (2000) 3, 100±106.

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“…The imaging technique involved: external multicoil arrays combined with an endorectal coil (Medrad Inc, Indianola, PA) that were used to allow imaging of the entire prostate and surrounding structures (7). Baseline prostate images were not obtained until at least 3 weeks (median, 1.0 [range, 0.8-3.0] months) after prostate biopsy to reduce the artifact that can be introduced from biopsy related intraprostatic hemorrhage (2).…”

Section: Emri Protocolmentioning

confidence: 99%

Tumor Volume Changes on 1.5 Tesla Endorectal MRI During Neoadjuvant Androgen Suppression Therapy for Higher-Risk Prostate Cancer and Recurrence in Men Treated Using Radiation Therapy Results of the Phase II CALGB 9682 Study

D’Amico

Halabi

Tempany

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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Purpose-We prospectively determined whether the change in tumor volume (TV) during 2 months of neoadjuvant androgen suppression therapy (nAST) measured using conventional 1.5 Tesla endorectal magnetic resonance imaging (eMRI) was associated with the risk of recurrence after radiation (RT) and 6 months of AST. 1997 and 2001, 180 men with clinical stage T1c-T3cN0M0 adenocarcinoma of the prostate were registered. Fifteen were found to be ineligible and the institutional MR radiologist could not assess the TV in 32, leaving 133 for analysis. Multivariable Cox regression analysis was used to assess whether a significant association existed between eMRIdefined TV progression during nAST and time to recurrence adjusting for prostate-specific antigen (PSA) level, Gleason score (8 to 10 or 7 vs. 6 or less) and stage (T3 vs. T1-2). Patients and Methods-BetweenResults-After a median follow up of 6.7 years and adjusting for known prognostic factors, there was a significant increase in the risk of PSA failure (HR, 2.3 [95% CI, 1.1-4.5; p = 0.025) in men with eMRI-defined TV progression during nAST. Specifically, adjusted estimates of PSA failure were significantly higher (p = 0.032) in men with, compared with men without, eMRI-defined TV progression reaching 38% vs. 19%, respectively, by 5 years. Conclusion-Eradicating

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Staging of prostate cancer: results of Radiology Diagnostic Oncology Group project comparison of three MR imaging techniques.

Abstract: No technique was highly accurate for staging early prostate cancer. Individual radiologists did achieve a high degree of staging accuracy with the endorectal-coil and body-coil combination.

Cited by 236 publications

References 0 publications

A new staging criterion for bladder carcinoma using gadolinium‐enhanced magnetic resonance imaging with an endorectal surface coil: a comparison with ultrasonography

A new staging criterion for bladder carcinoma using gadolinium‐enhanced magnetic resonance imaging with an endorectal surface coil: a comparison with ultrasonography

Ultrasound-guided seminal vesicle biopsies in prostate cancer

Tumor Volume Changes on 1.5 Tesla Endorectal MRI During Neoadjuvant Androgen Suppression Therapy for Higher-Risk Prostate Cancer and Recurrence in Men Treated Using Radiation Therapy Results of the Phase II CALGB 9682 Study

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