Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats

Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions

“…As indicated previously, BPC 157 has been tested in clinical trials as an agent against ulcerative colitis, but studies have shown its efficacy throughout complete gastrointestinal tract (Sikiric et al., ). BPC 157 reduces high myeloperoxidase (MPO) activity in colonic tissue (Veljaca et al., ), and in particular, heals fistulas (Baric et al., ; Grgic et al., ; Klicek et al., ), rescues failed anastomosis healing (Klicek et al., ; Sever et al., ; Vuksic et al., ), and markedly improves intestinal adaptation following massive bowel resection (Sever et al., ). Studies have shown different molecular mechanisms involved in BPC 157 beneficiary effects (Chang et al., , ; Hsieh et al., ; Huang et al., ).…”

Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye's Stress Coping Response: Progress, Achievements, and the Future

“…[73][74][75][76][77] Thus, we suggested that BPC 157 exerts its effect simultaneously in the healing of different tissues, and accommodate the healing processes in different tissues. 1 As a supportive analogy a clear demonstration of the rat fistulas healing appears, [82][83][84][85][86][87] and thereby simultaneously achieves healing in different tissues. In rat fistulas studies, [82][83][84][85][86][87] creation of the fistulas by anastomoses between the different tissues, accurately provides the defined defect in each of the tissues.…”

“…1 As a supportive analogy a clear demonstration of the rat fistulas healing appears, [82][83][84][85][86][87] and thereby simultaneously achieves healing in different tissues. In rat fistulas studies, [82][83][84][85][86][87] creation of the fistulas by anastomoses between the different tissues, accurately provides the defined defect in each of the tissues. Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously.…”

“…Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously. [82][83][84][85][86][87] A similar demonstration should be the creation of the different gastrointestinal anastomoses 57,[88][89][90][91][92] that would accordingly heal as opposed to commonly poor healing in the corresponding control rats. Thus, the healing of the esophagocutaneous, 82 gastrocutaneous, 83 duodenocutaneous, 84 colocutaneous, 85 vesicovaginalis, 86 and rectovaginalis fistulas, 87 assessed grossly, biomechanically and microscopically means demonstration of the both external and internal fistulas healing [82][83][84][85][86][87] and consequently, the realization of the simultaneous healing of different tissues.…”

“…[82][83][84][85][86][87] A similar demonstration should be the creation of the different gastrointestinal anastomoses 57,[88][89][90][91][92] that would accordingly heal as opposed to commonly poor healing in the corresponding control rats. Thus, the healing of the esophagocutaneous, 82 gastrocutaneous, 83 duodenocutaneous, 84 colocutaneous, 85 vesicovaginalis, 86 and rectovaginalis fistulas, 87 assessed grossly, biomechanically and microscopically means demonstration of the both external and internal fistulas healing [82][83][84][85][86][87] and consequently, the realization of the simultaneous healing of different tissues. Likewise, is the demonstration of the improved anastomoses healing, 57,[88][89][90][91][92] gastrointestinal (i.e., esophagogastric, esophagojejunal ileoileal, jejunoileal, colon anastomoses), 57,[88][89][90][91][92] but also nerve (sciatic nerve) 93 and vascular (abdominal aorta).…”