Stable fluorescent gold nanoparticles for detection of Cu<sup>2+</sup>with good sensitivity and selectivity

Guo, Yongming; Wang, Zhuo; Shao, Huawu; Jiang, Xingyu

doi:10.1039/c1an15877e

Cited by 110 publications

(65 citation statements)

References 55 publications

(6 reference statements)

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“…The results showed that the fluorescence intensity increased with increasing pH of solution up to a pH 7.4 and then remained more or less constant. This is because of deprotonation of Hb (with a pI of 6.8) on the surface of the Hb-AuNCs, at higher pHs, which resulted in repulsion among the fluorescent gold nanoclusters and thereby stabilizing system [27]. A measured zeta potential of −30.4±4.0 mV on Hb-AuNCs reflects such a great electrostatic repulsion between particles.…”

Section: Characterization Of Hb-auncsmentioning

confidence: 97%

“…3d, the corresponding plot of (F 0 /F) versus [Cu 2+ ] shows two excellent linear correlations graphs with \correlation coefficients (R 2 ) of 0.9973 and 0.9942, over the copper concentrations 0.1-1.0 μM and 1.0 to 20.0 μM, respectively. The LOD was calculated to be 28 nM (S/N=3), which is much lower than the safe limit of copper ions in drinking water (i.e., 1.3 ppm, 20 μM) established by the United States Environmental Protection Agency (EPA) [27].…”

Section: Signal-off Fluorescence Detection Of Cu 2+mentioning

confidence: 99%

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Novel blue-emitting gold nanoclusters confined in human hemoglobin, and their use as fluorescent probes for copper(II) and histidine

Shamsipur

Molaabasi

Shanehsaz³

et al. 2014

Microchim Acta

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We report on the synthesis and characterization of highly fluorescent gold nanoclusters (Au-NCs) from a gold precursor using a single-step chemical reduction in the presence of human adult hemoglobin (Hb). The conformational changes of Hb before and after cluster formation were studied by various spectroscopic techniques. The Au-NCs in Hb display blue fluorescence with a peak centered at 450 nm (photoexcited at 365 nm) and a quantum yield of 2.8 %. The Au-NCs exhibit excellent photostability and long-term stability, and can be applied in the pH range 5-12 even in the presence of high electrolyte concentrations. The Au-NCs in Hb can act as a highly sensitive and selective fluorescent turnoff probe for Cu(II) ion. The observed reversible fluorescence recovery of Hb-AuNCs/Cu(II) aggregates was exploited to develop a selective and sensitive turn-on fluorescence assay for His. Under optimized conditions, the probe gives a fluorescent response that is linear in the 0.1 to 20.0 μM concentration range of Cu(II), with a limit of detection of 28 nM. The probe for His, in turn, has a linear range in the 1-21 μM concentration range, and the limit of detection is 0.6 μM.

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Section: Characterization Of Hb-auncsmentioning

confidence: 97%

Section: Signal-off Fluorescence Detection Of Cu 2+mentioning

confidence: 99%

Novel blue-emitting gold nanoclusters confined in human hemoglobin, and their use as fluorescent probes for copper(II) and histidine

Shamsipur

Molaabasi

Shanehsaz³

et al. 2014

Microchim Acta

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“…Additionally, the paramagnetic feature of Cu 2? would also contribute to the emission quenching due to the generation of intersystem crossing process; thus, the transitions from excited states to ground states were reduced [23,24]. Furthermore, we have studied the correlation between the quenching effect (I 0 /I) and concentration of the guest species (F -or Cu 2? )…”

Section: Resultsmentioning

confidence: 98%

Dual-target optical sensors assembled by lanthanide complex incorporated sol–gel-derived polymeric films

Gao

Deng

et al. 2016

J Sol-Gel Sci Technol

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Sensors bearing functional units that could transform the chemical recognition into readable signals due to binding to single or even more targets have received much attention. Here, two F -/Cu 2? optical sensors based on lanthanide edifices were designed. The f-f forbidden transitions of lanthanide elements differ significantly from organic compounds since they exhibited favorable features such as narrow emissions and high color purity. Europium(III) complex of 2-(3-carboxyphenyl)imidazo [4,5-f]-1,10-phenanthroline (Eu-1) and europium(III) ternary complex of 2-(3-carboxyphenyl)imidazo[4,5-f]-1,10-phenanthroline and dibenzoylmethane (Eu-2) showed on-off changes in responses to the guest species. The excitation wavelength of Eu-2 could be extended to nearly visible light range, and this longer wavelength sensitisation will be useful in the selection of cheap laser sources.Generally organic complexes suffered from the instabilities in practical uses, the encapsulation of indicators into hosts will be necessary. Therefore, the lanthanide containing hybrid films which were composed of cross-linked siloxane and polymeric matrices were also prepared. The inorganic-organic film could be excited at 410 nm and demonstrated improved thermal stability. Moreover, we could detect F -and Cu 2? in aqueous mixed solution and this feature would be favorable for future uses.Graphical Abstract F -/Cu 2? optical lanthanide sensors were designed. The excitation wavelength of europium(III) complex with 2-(3-carboxyphenyl)imidazo[4,5-f]-1,10-phenanthroline and dibenzoylmethane (Eu-2) could be extended to nearly visible light range. Moreover, the Eu-2 doped film with cross-linked siloxane and polymeric hosts was also prepared. N N H N N HOOC Eu 3+ Cu 2+ F -O O -3 on-off

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“…Fluorescent AuNPs could be utilized in sensors for the purpose of heavy metal detection, controlling the growth of pathogens, imaging, etc. [23][24][25][26][27][28]. Some methods have already been developed to prepare fluorescent AuNPs, such as reduction of gold precursor with NaBH 4 in the presence of 11-mercaptoundecanoic acid in toxic organic solvent, reduction of gold precursor with biomolecules like bovine serum albumin (BSA) and etching pre-synthesized AuNPs with hyperbranched and multivalent polymers [23,29,30].…”

Section: Structurementioning

confidence: 99%

Size-controlled preparation of fluorescent gold nanoparticles using pamoic acid

et al. 2015

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We previously showed that pamoic acid (PA) could be utilized as a reducing and capping reagent for preparing monodispersed gold nanoparticles (AuNPs) with diameters of 10.8 nm. Here, we show that the size of these PA-capped AuNPs can be varied in a controlled manner by changing the pH used in the preparation process. By changing the added amount of NaOH in the PA solution before mixing with HAuCl 4 , several types of AuNPs were prepared at different pH values. The absorption spectra showed a red shift of the characteristic peak of the AuNPs with decreasing pH, indicating the formation of larger AuNPs. The TEM results confirmed this relationship between AuNP size and pH, and the zeta potentials indicated that the AuNPs capped with PA were more stable than the AuNPs prepared by citrate reduction method. Furthermore, the PA-capped AuNPs showed much higher fluorescence intensities than those of citrate-capped AuNPs, which is due to the fluorescence of PA. The sizes of PA-capped spherical AuNPs could also be controlled by a seed-mediated growth approach. However, the original PAcapped AuNPs, with diameters of 10.8 nm, exhibited the highest fluorescence intensities among the various types of PA-capped AuNPs that were grown. In addition to conferring fluorescence properties to the AuNPs, the capping by PA also provided the nanoparticles with carboxylate groups.

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Stable fluorescent gold nanoparticles for detection of Cu²⁺with good sensitivity and selectivity

Cited by 110 publications

References 55 publications

Novel blue-emitting gold nanoclusters confined in human hemoglobin, and their use as fluorescent probes for copper(II) and histidine

Novel blue-emitting gold nanoclusters confined in human hemoglobin, and their use as fluorescent probes for copper(II) and histidine

Dual-target optical sensors assembled by lanthanide complex incorporated sol–gel-derived polymeric films

Size-controlled preparation of fluorescent gold nanoparticles using pamoic acid

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Stable fluorescent gold nanoparticles for detection of Cu2+with good sensitivity and selectivity

Cited by 110 publications

References 55 publications

Novel blue-emitting gold nanoclusters confined in human hemoglobin, and their use as fluorescent probes for copper(II) and histidine

Novel blue-emitting gold nanoclusters confined in human hemoglobin, and their use as fluorescent probes for copper(II) and histidine

Dual-target optical sensors assembled by lanthanide complex incorporated sol–gel-derived polymeric films

Size-controlled preparation of fluorescent gold nanoparticles using pamoic acid

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Product

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Stable fluorescent gold nanoparticles for detection of Cu²⁺with good sensitivity and selectivity