Stability Study of Carboplatin in Aqueous Solution and Under Illumination by High Performance Liquid Chromatography

Stability study of carboplatin infusion solutions in 0.9% sodium chloride in polyvinyl chloride bags

“…Platinum compounds such as carboplatin are lightsensitive. 14,22,37,38 For instance, Torres et al 22 found that in 0.8 mg/mL and 3.2 mg/mL solutions of carboplatin-5% glucose exposed to light, 10% degradation occurred within 1-10 h depending on light intensity. 22 Similarly, Pujol et al 38 found that carboplatin Table 1.…”

“…11,12 Accordingly, the final diluted infusion solutions are stable up to 8 h at 25 C. 11,12 Currently, there is an abundance of stability data on carboplatin solutions prepared in D5W. [13][14][15][16][17][18][19][20][21][22] Many of these studies have been reviewed elsewhere, 23 and a comprehensive review of the data is beyond the scope of this manuscript. In brief, the stability of carboplatin-D5W infusion solutions stored at room temperature ($25 C) ranges from 1 day to 30 days in various administration packages.…”

Mechanisms of reaction of L‐methionine with carboplatin and oxaliplatin in different media: a comparison with cisplatin

“…The difference between our results and those of Knox relies on the different experimental conditions and especially the composition of the media of incubation. In fact, it has been shown that carboplatin, under some conditions was likely to give cisplatin hydrated species [28].…”

Stability of carboplatin infusion solutions used in desensitization protocol

“…The HPLC method of Carballar et al. 11 for carboplatin was adapted to our conditions. The HPLC system consisted of an Agilent 1200 system comprising a quaternary pump, an autosampler, a column compartment, and a diode array ultraviolet-visible (UV–vis) detector.…”