2015
DOI: 10.4314/bcse.v29i1.3
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: ABSTRACT. An accurate, simple and specific reverse phase LC procedure is established and validated for simultaneous estimation of methoxsalen and p-aminobenzoic acid in pharmaceutical formulated products and human serum. Chromatographic separation among methoxsalen, p-aminobenzoic acid and their degradation products have been achieved in less than 5 min with Hypersil-ODS column (250 mm x 4.6 mm, 5 µm), using acetonitrile and 1.28 mM phosphate buffer as mobile phase (60:40 v/v). Flow rate of the mobile phase wa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
4
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 10 publications
(4 citation statements)
references
References 15 publications
0
4
0
Order By: Relevance
“…Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. [3][4][5][6][7] There are few methods reported in the literature of Darunavir and Ritonavir alone or in combination with other drugs in the pure and pharmaceutical formulation by UV, HPLC and UPLC-MS [8][9][10][11][12][13][14][15][16][17][18][19][20] . In view of the need of suitable, cost effective RP HPLC method for routine analysis of simultaneous estimation of RTV and DRV in bulk and synthetic mixture (tablet dosage form), attempts we made do develop a simple, accurate, precise and cost effective analytical method for the estimation of RTV and DRV.…”
Section: Figure 2: Chemical Structure Of Ritonavirmentioning
confidence: 99%
See 1 more Smart Citation
“…Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. [3][4][5][6][7] There are few methods reported in the literature of Darunavir and Ritonavir alone or in combination with other drugs in the pure and pharmaceutical formulation by UV, HPLC and UPLC-MS [8][9][10][11][12][13][14][15][16][17][18][19][20] . In view of the need of suitable, cost effective RP HPLC method for routine analysis of simultaneous estimation of RTV and DRV in bulk and synthetic mixture (tablet dosage form), attempts we made do develop a simple, accurate, precise and cost effective analytical method for the estimation of RTV and DRV.…”
Section: Figure 2: Chemical Structure Of Ritonavirmentioning
confidence: 99%
“…Under these conditions, standards and analytical procedures for these drugs may not be available in the pharmacopoeias. It becomes necessary, therefore to develop newer analytical methods for such drugs 3 Darunavir [1] (DRV) is chemically (3R,3aS,6aR)hexahydrofuro[2, 3-b]…”
Section: Introductionmentioning
confidence: 99%
“…1 Methoxsalen belongs to the class of furanocoumarins, a class of organic natural molecules which comprises of coumarin moiety annulated with furan 2 (Figure 1). Psoralens are estimated and quantified using numerous analytical methods such as Reversed phase-High Pressure Liquid Chromatography (RP-HPLC), [1][2][3][4][5][6][7] ultraperformance liquid chromatographytandem mass spectrometry (UPLC-MS/ MS), 8 LC-MS-MS, 9 Ultraviolet-Visible Spectrophotometry (UV-Vis Spectrophotometry), 10 Thin-layer chromatography (TLC) 11 and other methods. The current literature exists with UV spectrophotometric determination of methoxsalen in different medium such as ethanol.…”
Section: Introductionmentioning
confidence: 99%
“…Reviewing the literature resulted in the occurrence of few methods for this FDC [22][23], however no stability indicating HPLC method was found for this FDC. We are involved recently to conduct research relating to method development of FDC of different drugs with varying chemical properties and many of these papers have been reported in the literature [24][25][26][27][28][29][30][31][32][33][34][35][36]. In order to fill this knowledge gap, it was attempted to develop and validate HPLC method with stability indicating properties for this FDC (ciprofloxacin and dexamethasone) not only in commercial formulations but also in human serum and urine.…”
mentioning
confidence: 99%