2017
DOI: 10.1590/s2175-97902017000115177
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Abstract: In this study, conditions were optimized for development of a simple RP-HPLC method for simultaneous analysis of gatifloxacin and dexamethasone in different matrices like pharmaceuticals, human serum and urine. Good separation of gatifloxacin and dexamethasone from the induced degradation products was accomplished using C8 as stationary phase; 0.02 M phosphate buffer (pH 3. .999). Both the analyte peaks were completely separated from the peaks of induced degradation products as indicated by the peak purity ind… Show more

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Cited by 7 publications
(3 citation statements)
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“…The newly developed method had shown better sensitivity relative to previously reported methods with an LOD of 0.489 μg ml −1 for OFX, 0.654 μg ml −1 for GFN, 0.891 μg ml −1 for DSP and 0.658 μg ml −1 for PA (Agarwal, Dadhich, Tiwari, & Nagariya, 2013; Razzaq et al, 2017; Yu, 2014). The LOD and LOQ were calculated utilizing the signal‐to‐noise ratio method (ICH, 2005).…”
Section: Resultsmentioning
confidence: 83%
“…The newly developed method had shown better sensitivity relative to previously reported methods with an LOD of 0.489 μg ml −1 for OFX, 0.654 μg ml −1 for GFN, 0.891 μg ml −1 for DSP and 0.658 μg ml −1 for PA (Agarwal, Dadhich, Tiwari, & Nagariya, 2013; Razzaq et al, 2017; Yu, 2014). The LOD and LOQ were calculated utilizing the signal‐to‐noise ratio method (ICH, 2005).…”
Section: Resultsmentioning
confidence: 83%
“…[ 13 ] Several approaches for determining GTF have been reported such as spectrophotometry, [ 14,15 ] spectrofluorimetry, [ 16,17 ] and HPLC methods. [ 18–20 ]…”
Section: Introductionmentioning
confidence: 99%
“…[13] Several approaches for determining GTF have been reported such as spectrophotometry, [14,15] spectrofluorimetry, [16,17] and HPLC methods. [18][19][20] Micellar mobile phase (MLC) has recently sparked a lot of interest in liquid chromatography. Diverse types of interactions including hydrophobic, electrostatic, and steric exist between the solute and both the mobile and stationary phases were afforded.…”
Section: Introductionmentioning
confidence: 99%