Stabilin Receptors Clear LPS and Control Systemic Inflammation

Cabral, Fatima; Al-Rahem, Mustafa; Skaggs, John; Thomas, Thushara; Kumar, Naresh; Wu, Qian; Fadda, Paolo; Yu, Lianbo; Robinson, John M.; Kim, Jonghan; Jarjour, Wael; Rajaram, Murugesan V. S.; Harris, Edward N.; Ganesan, Latha P.

doi:10.2139/ssrn.3845681

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…37 42 However, LSECs are known to play a key role in the clearance of bacterial LPS, 56 viruses, 57 and viral particles 58 from the bloodstream in vivo and have been shown to interact with several microbial antigens in vitro. 59 60 61 In fact, a recent study has implicated LSEC-expressed stabilin-1 and stabilin-2 in the systemic clearance of LPS 62 ; therefore, the role of LSEC-expressed scavenger receptors in hepatic innate immunity warrants future investigation.…”

Section: Scavenger Receptors In Liver Homeostasismentioning

confidence: 99%

Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer

et al. 2021

View full text Add to dashboard Cite

The scavenger receptor superfamily represents a highly diverse collection of evolutionarily-conserved receptors which are known to play key roles in host homeostasis, the most prominent of which is the clearance of unwanted endogenous macromolecules, such as oxidized low-density lipoproteins, from the systemic circulation. Members of this family have also been well characterized in their binding and internalization of a vast range of exogenous antigens and, consequently, are generally considered to be pattern recognition receptors, thus contributing to innate immunity. Several studies have implicated scavenger receptors in the pathophysiology of several inflammatory diseases, such as Alzheimer's and atherosclerosis. Hepatic resident cellular populations express a diverse complement of scavenger receptors in keeping with the liver's homeostatic functions, but there is gathering interest in the contribution of these receptors to hepatic inflammation and its complications. Here, we review the expression of scavenger receptors in the liver, their functionality in liver homeostasis, and their role in inflammatory liver disease and cancer.

show abstract