Squamous Cell Carcinoma of the Vulva Secondary to Granuloma Inguinale

Unusual Gynaecological Presentations of Donovanosis Pseudoelephantiasis and Carcinoma of the Cervix

“…Donovanosis and squamous cell carcinoma of the uterine cervix may coexist (6), and it has been suggested that Donovanosis may be a premalignant condition (13,14). In this patient (case 2) where the typical beefy-red granulation of Donovanosis was not present, and where there was a necrotic looking cervix with both bladder and right ureteric involvement associated with a right pelvic side-wall mass, it was therefore essential to exclude an associated advanced malignancy.…”

Donovanosis

“…An interesting association between granuloma inguinale and genital carcinoma has been suggested but not established (48,120,(122)(123)(124)(125)(126). In Papua New Guinea, carcinoma of the penis occurs primarily in areas where granuloma inguinale is endemic (48).…”

“…Complement fixing antibodies were detected in about 15% of male patients with penile carcinoma, while antibody was not found among control sera (39). However, carcinoma of the penis is also associated with low socioeconomic status, poor personal hygeine, promiscuity, and -c high rates of venereal disease (39, 125,127), factors common in patients with granuloma inguinale. In addition, some cases of alleged genital carcinoma coincident with or due to granuloma inguinale may actually represent the infection simulating a malignancy (120,128) Pseudoelephantiasis (11,55,75,129) ofthe genitals is another disfiguring complication ( Fig.…”