Squamous cell carcinoma of supraglottic larynx with metastasis to all five distal phalanges of left hand

Kumar, Narendra; Bera, Anjan; Kumar, Ritesh; Ghoshal, Sushmita; Angurana, Shabab; Srinivasan, Radhika

doi:10.4103/0019-5154.87161

Cited by 12 publications

(12 citation statements)

References 8 publications

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“…We've had 2 cases of laryngeal Squamous Cell Carcinomas (SCC) with subcutaneous metastasis in the neck regions which has been confirmed by tissue biopsy. Laryngeal SCC most commonly metastasizes to lung and liver [6]. Subcutaneous metastasis in this tumor has been rarely reported.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Subcutaneous Metastatic Deposits by Fine Needle Aspiration

Geramizadeh¹

2012

J Cytol Histol

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Objectives: Subcutaneous tissue is an uncommon site of metastasis. Overall it can be seen in 0.8-4% of the malignancies. Fine Needle Aspiration Cytology (FNAC) is a method for the diagnosis of subcutaneous metastasis and to exclude other differential diagnoses such as primary cutaneous tumors or inflammatory process. In this study we want to report our experience with Fine Needle Aspiration (FNA) of subcutaneous metastasis in 25 patients with known malignancy.Study design: During 3 years, among more than 10000 cytology cases, we had 25 patients with different types of malignancy who were referred with subcutaneous nodules. FNA was performed. Results:In these 25 patients, there were 15 males and 10 female patients (22-80 years of age). Most common malignancy was breast cancer and the most common site of metastasis was subcutaneous tissue of chest wall. FNAC was 100% accurate for the diagnosis of subcutaneous metastasis. There were no false positive and false negative cases. Discussion and conclusion: FNAC is an accurate, noninvasive and fast method for the diagnosis of subcutaneous metastasis in the patients with a known malignancy without any complication.

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Section: Discussionmentioning

confidence: 99%

Diagnosis of Subcutaneous Metastatic Deposits by Fine Needle Aspiration

Geramizadeh¹

2012

J Cytol Histol

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“…20 They have been reported to occur at different sites all throughout the body such as head, neck, thorax, upper extremities, abdomen, buttock, and lower extremities. [4][5][6][7][8][9][10][11][12]21 (Table 1) elaborates on sites of metastasis, treatments offered and outcomes in patients with skin metastasis in treated cases of SCC larynx. Treatment options such as radiotherapy, chemotherapy, and excision of skin lesions were considered.…”

Section: Discussionmentioning

confidence: 99%

“…3 That too, metastasis to skin in a treated case of SCC of the larynx is extremely rare. [4][5][6][7][8][9][10][11][12] It generally denotes impending distant metastatic spread or locoregional recurrence, and poor prognosis. On review of literature, there were only few reports of cutaneous metastasis in treated SCC of larynx and limited information on potential treatment options.…”

Section: Introductionmentioning

confidence: 99%

Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

Selvaraj

Gudipudi

2020

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Cutaneous metastasis from squamous cell carcinoma (SCC) of larynx is very uncommon. Skin mestatsis in a treated of case of SCC larynx is considered to be a sign of impending distant metastasis and dismal prognosis. There are very few case reports in literature describing such presentations, and very minimal information on treatment options available for these patients. Here, we describe two cases of locally advanced SCC larynx treated with chemoradiation upfront, who later presented with cutaneous metastasis in neck within the previous radiation field. Evaluation for distant metastasis was done and started on palliative chemotherapy. The first patient had complete resolution of cutaneous nodules post 8 cycles of weekly palliative chemotherapy. However, post 18 cycles of chemotherapy, he developed a metachronous primary in upper thoracic oesophagus and disease progressed loco-regionally too. The second patient’s general condition deteriorated after 1st cycle of palliative chemotherapy, hence was offered best supportive care. Cutaneous nodules in a treated SCC of larynx must raise the suspicion of metastasis, warranting histological examination, and whole-body imaging work-up to rule out distant metastasis. Palliative chemotherapy must be advocated in all eligible patients to delay disease progression. Best supportive care can be offered in patients not eligible for chemotherapy.</p>

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“…Skin metastasis indicates a poor prognosis. [ 9 ] Berger and Fletcher[ 10 ] in their study reported that length of survival was approximately 3 months after skin metastasis becomes clinically evident in HNSCC. The treatment intent is usually palliative with the available options being surgical excision, chemotherapy, External beam radiotherapy or a combination of these.…”

Section: Discussionmentioning

confidence: 99%