Squamous cell carcinoma. Occurrence in mycosis fungoides treated with psoralens plus long-wave ultraviolet radiation

Abstract

In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA). In both patients the carcinoma developed on areas not usually exposed to sunlight. Before receiving PUVA therapy one patient had been treated with topically applied thiotepa and x-ray irradiation, while in the other patient PUVA was the only treatment received except for topical corticosteroids. The carcinomas developed after a total UVA dose of 2,042 and 1,296 joules/sq cm, respectively.

Malignant Melanoma Associated with Mycosis fungoides

“…MM was not observed in the study. Epithelial malignancies associated with MF has been attributed to PUVA therapy, radi ation therapy, topical nitrogen mustard or a combination ofthese treatments [2,3]. How ever, squamous cell carcinoma has been re corded in a case report of MF independent of treatment [4], Furthermore, one squamous cell carcinoma and two basal cell carcino mas were found in a patient with a long his tory of poikiloderma [5] with later develop ment of MF.…”

Multiple squamous cell carcinomas in a patient with mycosis fungoides

“…The latency period between use of nitrogen mustard and the development of carcinoma is said to be at least 2–5 years 2 . Photochemotherapy has been associated with an increased rate of non‐melanomatous skin carcinoma 5,6 . There has been a report of one patient with MF who developed a fatal SCC on the back, 9 years after receiving TSEB therapy and 4 years after PUVA therapy.…”

An Aggressive Spindle Cell Squamous Carcinoma Arising in a Patient with Long‐standing Erythroderma

“…The patient might have had impaired tumor immunity, so that the invasion was deep and metastases occurred. There have been, on the other hand, some earlier reports discussing the relationship of T cell lymphoma and aggressive behavior of see (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). In most of such cases, see developed after treatment with carcinogenic agents such as electron beam, PUVA, and topical nitrogen mustard (2-4, 7-9, 12-14).…”