Squamous cell carcinoma arising in long-standing necrobiosis lipoidica

Clement, M.

doi:10.1001/archderm.121.1.24

Cited by 13 publications

(8 citation statements)

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“…In this respect, most of our patients showed a lack of compliance or adherence, despite the psychological strain caused by the cosmetically disfiguring ulcerations and the pain. In addition, regular follow-up is necessary because it has been shown that long-standing chronic ulcerating lesions of necrobiosis lipoidica can lead to squamous cell carcinoma owing to malignant transformation as described in several case reports (28)(29)(30). In addition, an adequate pain therapy is necessary, because all patients in our group described their ulcerations as very painful.…”

Section: Treatmentmentioning

confidence: 90%

Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers: case report series of ten patients

Franklin

Stoffels-Weindorf

Hillen

et al. 2013

International Wound Journal

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Necrobiosis lipoidica is a rare granulomatous disorder of the skin. In up to 30% of the affected patients it can lead to ulcerations, which can impair the quality of life and are also very difficult to treat. Its pathogenesis is not fully understood. Only few studies focussing on necrobiosis lipoidica can be found, but none of them focus on ulcerated necrobiosis lipoidica. Therefore, we collected demographic data and comorbidities and assessed treatment options for patients with ulcerated necrobiosis lipoidica. Data of patients who were treated in the wound care centre of the University Hospital of Essen for ulcerated necrobiosis lipoidica over the past 10 years were retrospectively analysed. Hence, data of altogether ten patients (nine women and one man) with ulcerated necrobiosis lipoidica were collected. Of these, 70% of the patients had diabetes mellitus of which 30% had type I diabetes and 40% had type II diabetes; 60% of the patients suffered from arterial hypertension, obesity and hypercholesterolaemia; 40% of the patients suffered from psychiatric disorders such as depression and borderline disorder. Our clinical data demonstrate an association of ulcerated necrobiosis lipoidica and aspects of metabolic syndrome. This leads to a conclusion that ulcerating necrobiosis lipoidica can be seen as part of a generalised inflammatory reaction similar to the inflammatory reaction already known in the pathophysiology of rheumatoid diseases or psoriasis. In patients with clinical atypical painful ulcerations, necrobiosis lipoidica should be considered as a possible differential diagnosis. Therapists should be aware of associated aspects in patients with ulcerated necrobiosis lipoidica who besides diabetes often suffer from other aspects of a metabolic syndrome with increased cardiovascular risk factors. Therefore, these related comorbidities should also be diagnosed and treated.

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Section: Treatmentmentioning

confidence: 90%

Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers: case report series of ten patients

Franklin

Stoffels-Weindorf

Hillen

et al. 2013

International Wound Journal

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“…Chronic scarring conditions include burn scars, vaccination sites, sinuses, stasis ulcers, cutaneous discoid lupus erythematosus, lupus vulgaris, and dystrophia epidermolysis bullosa. 7,11,12,14,15 However, it has rarely been described as arising from an area of NL. Although lesions of NL may resolve spontaneously, most become chronic and develop ulcerations which usually occur after trauma.…”

Section: Discussionmentioning

confidence: 99%

“…To the author's knowledge, only nine cases have been reported so far. [5][6][7][8][9][10][11][12][13] We report another case which occurred in a patient with poorly controlled Type 1 diabetes mellitus and review the literature.…”

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confidence: 99%

Squamous cell carcinoma arising in an area of long‐standing necrobiosis lipoidica

Lim¹,

Tschuchnigg²,

Lim

2006

J Cutan Pathol

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“…Trente-cinq pour cent des patients atteints de NLD déve-lopperont des ulcérations [1]. Une NLD ancienne, comme nombre d'affections cutanées chroniques, peut se transformer en un épithélioma malpighien de la peau comme le décrivent certains auteurs [1,[9][10][11]. La biopsie des lésions de la NLD montre habituellement un épiderme normal excepté lorsqu'il y a ulcération, auquel cas, ce dernier peut être atrophié, voire absent.…”

Section: Discussionunclassified

Signes cliniques et anatomopathologiques d'une atteinte cutanée similaire à une nécrobiose lipoïdique au cours d'une sarcoïdose

Mendoza

Vahid

Weibel

2007

Revue du Rhumatisme

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Squamous cell carcinoma arising in long-standing necrobiosis lipoidica

Cited by 13 publications

References 0 publications

Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers: case report series of ten patients

Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers: case report series of ten patients

Squamous cell carcinoma arising in an area of long‐standing necrobiosis lipoidica

Signes cliniques et anatomopathologiques d'une atteinte cutanée similaire à une nécrobiose lipoïdique au cours d'une sarcoïdose

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