Squamous cell carcinoma. A population-based incidence study in Rochester, Minn

Chuang, Tsu‐Yi

doi:10.1001/archderm.126.2.185

Cited by 111 publications

(137 citation statements)

References 8 publications

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“…In both subroups, men were more In the present study, 4.1% of all BCC lesions and 1.8% of all SCC lesions locally recurred dur ing the 7.5-years period, roughly agree ing with the observations from previous studies [27][28][29][30]. However, as they represented only microscopically verified cases, a certain number of tumor relapses could have been subsequently treated non-invasively without histopathologic examination.…”

Section: Resultssupporting

confidence: 91%

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Bartoš¹,

Kullová²

2018

Klin Onkol

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SummaryBackground: Non-melanoma skin cancer (NMSC) is the most common malignancy in Caucasians. It mainly includes two major keratinocyte tumors -basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The objective of the study was to analyze and compare the clinicopathological differences between patients with BCC and SCC of the skin. Material and Methods: A cohort of 541 patients with a total of 719 BCCs, and 126 patients with a total of 162 SCCs were retrospectively analyzed. Results: While there was virtually the same proportion of men (49.91%) and women (50.09%) in BCC patients, SCCs occurred more frequently in men (68.2%) than in women (31.8%). The mean age of the individuals with BCC and SCC was 70.8 and 78.2 years, resp. The number of BCCs rises from 50 years of age and this increase showed a linear trend up to 80 years, subsequently followed by decline. SCC lesions occur more rapidly from 70 years of age followed by a sharp increase that exhibited an exponential relationship. BCCs and SCCs occurred predominantly on the head and neck region, compris ing a total of 69.8% and 81.4% of the cases, resp. However, BCC lesions were seen more often on the face and SCC lesions were dia gnosed more frequently on the extra-facial parts of the head. Further, BCCs occurred more frequently on the trunk, and particularly on the back, compared to SCCs. Conclusion: Although BCC and SCC are covered under common term NMSC, they manifest several clinicopathological differences. Despite shar ing common etiologic determinants, at least from the onco-epidemiologic perspective, they should be considered separately.

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Section: Resultssupporting

confidence: 91%

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Bartoš¹,

Kullová²

2018

Klin Onkol

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“…In 1988, more than 400,000 cases of BCC were diagnosed in the USA 32 , as opposed to 980,000 cases diagnosed for all other types of cancer together. In the Rochester region, (USA), Chuang et al 7 detected a prevalence of 146 cases per 100,000 inhabitants, while the prevalence estimated in Australia was 1,335 per 100,000 inhabitants for men and 817 per 100,000 inhabitants for women 21 .…”

Section: Introductionmentioning

confidence: 99%

Risk factors for basal cell carcinoma: a case-control study

1995

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A controlled trial was performed with the purpose of investigating which factors could be considered of significant risk for the development of basal cell carcinoma. A total of 259 cases of basal cell carcinoma diagnosed from July 1991 to July 1992 were compared with 518 controls matched for age and sex. All subjects in both groups were white. Protocol data were submitted to statistical analysis by the chi-square test and by multiple conditional logistic regression analysis and the following conclusions were reached: 1) light skin color (types I and II of the Fitzpatrick classification), odds ratio of 2.8; outdoor work under constant sunlight, odds ratio of 5.0; the presence of actinic lesions due to exposure to the sun, odds ratio of 4.9, are risk factors perse. 2) Type III skin in the Fitzpatrick classification only represents a risk factor when the patient reports a history of intense sunburns, but not in the absence of such a history. 3) Sunburns per se do not represent a risk factor althorig the point made in item 2 of these conclusions is valid. 4) Other suspected risk factors whose significance was not confirmed by multiple conditioned logistic regression analysis were: residence in rural areas, light eyes and blond hair color, extent of the awareness of the "sun x skin cancer" relationship, familial occurrence of skin cancer, excessive exposure to the sun, and freckles appearing in childhood.Carcinoma, basal cell, epidemiology.Risk factors.

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“…(Frost and Green, 1994) and over 75% of NMSCs (Gallagher et al, 1990;Chuang et al, 1990) occur on sun-exposed areas of the skin, this limited skin examination gave a high probability of detecting lesions with minimum disruption and embarrassment for these elderly study subjects. (Graham et al, 1985) and takes account of the substantial UV radiation exposure that can occur on cloudy days (Marks, 1990).…”

mentioning

confidence: 97%

Non-melanoma skin cancer and solar keratoses. I. Methods and descriptive results of the South Wales Skin Cancer Study

Harvey

Frankel²,

Marks³

et al. 1996

Br J Cancer

115

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Summary This study aimed to describe the prevalence and incidence of solar keratoses and skin cancers and the natural history of solar keratoses in a random population sample. It was a cross-sectional study, with follow-up, conducted in South Wales, and involved 1034 subjects aged 60 years and over drawn from the Family Health Services Authority register. The main outcome measures were detection of the presence of solar keratoses and skin cancers on sun-exposed skin and photographic validation of solar keratoses and biopsy confirmation of cancers wherever possible. We found that solar keratosis prevalence was 23% (95% confidence interval 19.5-26.5) and that of skin cancer (all types) 2% (95% confidence interval 1.0-3.5). The incidence rate of solar keratoses was 149 lesions per 1000 person-years and of non-melanoma skin cancer 9 per 1000 person-years. In all 21% (95% CL 16-26) of solar keratoses regressed spontaneously during follow-up. None underwent malignant change. We believe that the failure of individuals to seek medical advice and the variable under-registration of non-melanoma skin cancer makes population-based study important. The high prevalence and incidence of malignant and pre-malignant skin lesions in this random sample raise major public health concerns. The high rate of spontaneous regression of solar keratoses and the low rate of malignant change challenges conventional views about the need for routine treatment of these lesions.

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Squamous cell carcinoma. A population-based incidence study in Rochester, Minn

Cited by 111 publications

References 8 publications

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Risk factors for basal cell carcinoma: a case-control study

Non-melanoma skin cancer and solar keratoses. I. Methods and descriptive results of the South Wales Skin Cancer Study

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