Squamous cell cancer – 31-year epidemiological study in a city of south                   Brazil

Nasser, Nilton; Filho, Nilton Nasser; Lehmkuhl, Rafaela Ludvig

doi:10.1590/abd1806-4841.20153465

Cited by 16 publications

(17 citation statements)

References 13 publications

(34 reference statements)

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“…In BCC, the trunk, especially the back, was more frequently involved in men than women, and in comparison, the head and neck region and lower limbs were more frequently affected in women, also corroborating the results from another author [10,11,15,16]. When we regarded the head and neck region alone, males had more commonly involved extrafacial part of the head and neck compared to women in both BCC and SCC lesions, similar to the findings of another study [3,4,9,10]. This is probably due to thicker and longer hair cover in females, which provide better protection against UVR-light.…”

Section: Discussionsupporting

confidence: 90%

“…In MM, there was a high male to female ratio (2.6) for tumors of the trunk and low male to female ratio (0.5) for tumors of the leg. In SCC, the head and neck accounted for a larger proportion of lesions for men than women, and the lower limbs were affected more commonly (in our series exclusively) in women, justifying literature data [3,9,15,16,27]. In BCC, the trunk, especially the back, was more frequently involved in men than women, and in comparison, the head and neck region and lower limbs were more frequently affected in women, also corroborating the results from another author [10,11,15,16].…”

Section: Discussionsupporting

confidence: 82%

“…Although it is generally accepted that both BCCs and SCCs develop most frequently in the head and neck region, the percentages of tumors in this body part significantly differ among analyses conducted from various countries. Most of the published documents comprising Italian [3], Slovakian [8], Brasilian [9][10][11], Portuguese [12], and Romanian [7], or Iranian [13] studies have found, the head and neck represented 73.6-96.8% of all BCCs [3,7,8,[10][11][12][13] and 70.2-77.6% of all SCCs [3,[7][8][9]12] analyzed. In this study, this body part comprised 69% of BCCs and 81.5% of SCCs diagnosed, corroborating above-mentioned papers.…”

Section: Discussionmentioning

confidence: 99%

“…These UVR-related differences result in distinct anatomic distribution of the skin cancer types. In general, while MMs arise most commonly on the trunk and limbs [2][3][4][5][6][7], the vast majority of research papers have clearly demonstrated [3,[7][8][9][10][11][12][13] that NMSC occurs predominantly on the head and neck region. In spite of that, however, some studies [4,5,[14][15][16] have found discrepant percentages of BCCs and SCCs at individual body parts compared with the above-mentioned papers and as a consequence, the relative tumor density (RTD) has showed wide variations.…”

Section: Introductionmentioning

confidence: 99%

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Body Site Distribution and Relative Tumor Density of Different Human Cutaneous Malignancies with Emphasis on Sunlight Exposure: A Single Institution Experience

Barto¹,

Kullová²

2017

J Environ Occup Sci

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INTRODUCTIONHuman skin cancers encompass a wide spectrum of malignant conditions with different epidemiologic and clinical characteristics. The three most common malignancies include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), also referred to, collectively, as nonmelanoma skin cancer (NMSC), and malignant melanoma (MM). Although their etiopatogenesis is complex, there is persuasive evidence that an ultraviolet radiation (UVR) has a vital role in the development of each of these main tumor types [1]. However, the relative relationship between the sunlight exposure and the genesis of BCC, SCC, and MM seems to be tumor-specific [1]. These UVR-related differences result in distinct anatomic distribution of the skin cancer types. In general, while MMs arise most commonly on the trunk and limbs [2][3][4][5][6][7], the vast majority of research papers have clearly demonstrated [3,[7][8][9][10][11][12][13] that NMSC occurs predominantly on the head and neck region. In spite of that, however, some studies [4,5,[14][15][16] have found discrepant percentages of BCCs and SCCs at individual body parts compared with the above-mentioned papers and as a consequence, the relative tumor density (RTD) has showed wide variations. The RTD measure was first introduced by Pearl and Scott [17] in 1986, to create a standard way of comparing skin cancers distribution by anatomical sites. It considers the ratio between the proportion of tumor in a certain location and the proportion of the surface area on the same location. This index highlights the differences between the expected and observed occurrence of tumors by site. In this study, we have evaluated the topographic distribution and RTD of three types of cutaneous neoplasms mentioned above and confronted our results with eligible literature data. Results: MMs occurred most commonly on the trunk (46.8%) and the upper limbs (25.3%). While the back and the trunk in particular was sites with the most frequent MM development in males (64.3% and 45.9%), the upper limbs were the most common location in females (34.1%). BCCs and SCCs occurred predominantly on the head and neck, comprising a total of 69.0% and 81.5% of the cases. The face was a region with by far the highest RTDs in BCC and SCC patients. Men had more frequently affected extrafacial sites of the head and neck compared to women in both BCC (46% vs. 31.9%) and SCC (62.5% vs. 48.3%) cases. In BCC, the second most frequent anatomic site included the back in both genders (25.1% in males, 18.2% in females), but in SCC, it represented the trunk as a whole in males (13.6%), and the lower limbs in females (14.3%). The greatest differences in RTDs between BCC and SCC were on the back (BCC: SCC ratio, 7.5:1), especially in men (BCC: SCC ratio, 9:1). Conclusion: We have confirmed striking heterogeneity for skin cancer risk by anatomic site. While MMs arise predominantly on the body parts intermittently exposed to the sunlight, BCCs and especially SCCs develop most frequently on the sites that are habitually exposed to ...

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“…For statistical analysis, chi-square test was employed and p < 0.05 was considered significant. [1,12,17] analyzed. In the current study, this anatomic part comprised 69.8% of BCCs and 81.4% of SCCs diag nosed, corroborat ing the papers mentioned above.…”

Section: Kľúčové Slovámentioning

confidence: 99%

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Bartoš¹,

Kullová

2018

Klin Onkol

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SummaryBackground: Non-melanoma skin cancer (NMSC) is the most common malignancy in Caucasians. It mainly includes two major keratinocyte tumors -basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The objective of the study was to analyze and compare the clinicopathological differences between patients with BCC and SCC of the skin. Material and Methods: A cohort of 541 patients with a total of 719 BCCs, and 126 patients with a total of 162 SCCs were retrospectively analyzed. Results: While there was virtually the same proportion of men (49.91%) and women (50.09%) in BCC patients, SCCs occurred more frequently in men (68.2%) than in women (31.8%). The mean age of the individuals with BCC and SCC was 70.8 and 78.2 years, resp. The number of BCCs rises from 50 years of age and this increase showed a linear trend up to 80 years, subsequently followed by decline. SCC lesions occur more rapidly from 70 years of age followed by a sharp increase that exhibited an exponential relationship. BCCs and SCCs occurred predominantly on the head and neck region, compris ing a total of 69.8% and 81.4% of the cases, resp. However, BCC lesions were seen more often on the face and SCC lesions were dia gnosed more frequently on the extra-facial parts of the head. Further, BCCs occurred more frequently on the trunk, and particularly on the back, compared to SCCs. Conclusion: Although BCC and SCC are covered under common term NMSC, they manifest several clinicopathological differences. Despite shar ing common etiologic determinants, at least from the onco-epidemiologic perspective, they should be considered separately.

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Squamous cell cancer – 31-year epidemiological study in a city of south Brazil

Cited by 16 publications

References 13 publications

Body Site Distribution and Relative Tumor Density of Different Human Cutaneous Malignancies with Emphasis on Sunlight Exposure: A Single Institution Experience

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

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