1997
DOI: 10.1590/s0100-879x1997000500015 View full text |Buy / Rent full text
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Abstract: Lactating rat dams were submitted to short episodes (1, 2 or 3 weeks) of nutritional restriction by receiving the "regional basic diet" (RBD, with 8% protein) of low-income human populations of Northeast Brazil. Their pups were then studied regarding the developmental effects on body and brain weights. When the rats reached adulthood, cortical susceptibility to the phenomenon of spreading depression (SD) was evaluated by performing electrophysiological recordings on the surface of the cerebral cortex. SD was e… Show more

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“…Concerning nutritional deficiency, CSD-susceptibility was increased in rats malnourished early in life, as judged by its higher CSD velocities, in comparison to the well-nourished rats, confirming previous studies (Andrade et al 1990;Rocha-De-Melo and Guedes 1997;Santos Monteiro et al 2000;Amâncio-dosSantos et al 2006). Deficient myelination, increased brain cell packing density, altered neuron-to-glia ratio and synaptic neurotransmitters are the most suggested mechanisms to explain the effect of early malnutrition on cortical CSD (De Luca et al 1977;Rocha-DeMelo and Guedes 1997).…”
Section: Malnutrition-pe Interaction On Cortical Spreading Depressionsupporting
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“…Concerning nutritional deficiency, CSD-susceptibility was increased in rats malnourished early in life, as judged by its higher CSD velocities, in comparison to the well-nourished rats, confirming previous studies (Andrade et al 1990;Rocha-De-Melo and Guedes 1997;Santos Monteiro et al 2000;Amâncio-dosSantos et al 2006). Deficient myelination, increased brain cell packing density, altered neuron-to-glia ratio and synaptic neurotransmitters are the most suggested mechanisms to explain the effect of early malnutrition on cortical CSD (De Luca et al 1977;Rocha-DeMelo and Guedes 1997).…”
Section: Malnutrition-pe Interaction On Cortical Spreading Depressionsupporting
“…Malnutrition facilitates CSD in the rat brain (De Luca et al 1977), and this condition has been extensively demonstrated in our laboratory (Guedes et al 1987;Andrade et al 1990;Rocha-de-Melo and Guedes 1997;Rocha-de-Melo et al 2006), and confirmed in the present study, as indexed by the CSD velocities in the naïve condition, which were higher in the malnourished group, as compared to the well-nourished one (see Fig. 3).…”
Section: Amplitudes (Mv) Duration (S) Rise Times (S) Recovery Times (S)supporting
“…This study provides further evidence that early malnutrition can lead to endocrine disruption , Ramos et al 1997, Rocha de Melo & Guedes 1997, Teixeira et al 2002. The maternal nutritional state during lactation is equivalent and possibly even more important than that during gestation, as evidenced by a study from Léonhard et al (2003) that showed that the offspring whose dams were malnourished during lactation had more drastic consequences on gonadal development when compared with the offspring whose dams were malnourished only during pregnancy or during pregnancy and lactation.…”
Section: Discussionmentioning
“…Undernutrition is known to have a wide variety of effects on endocrine systems (Rocha de Melo & Guedes 1997, Cónsole et al 2001. Regarding the reproductive system, it has been shown that food restriction can inhibit both the maintenance and onset of reproductive capability (Desjardins & Lopez 1983).…”
Section: Introductionmentioning