Sprayed Fibrin Sealant as the Sole Hemostatic Agent for Porcine Laparoscopic Partial Nephrectomy

Pick, Donald L.; Kolla, Surendra B.; Mucksavage, Phillip; Louie, Michael K.; Sountoulides, Petros; Kaufmann, Oskar Grau; Olamendi, Stephania; Kaplan, Adam; Huynh, Victor; Ortiz-Vanderdys, Cervando; Truong, H. P.; Said, Shary; Andrade, Lorena A.; Tongson-Ignacio, Jane; McDougall, Elspeth M.; Clayman, Ralph V.

doi:10.1016/j.juro.2010.09.002

Cited by 16 publications

(10 citation statements)

References 19 publications

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“…The knee was closed in layers prior to performing a carbon dioxide (CO 2 ) insufflated arthroscopy (Smith & Nephew) with a standard anterolateral approach. The two-component holder of the cell laden (2 Â 10 6 cells/ml) fibrin glue was connected to the DuploSpray system which was originally designed to spray a fibrin sealant as a hemostatic agent for laparoscopic surgery 17,18 . For the cadaveric study, both chondrons (n ¼ 3) and chondrocytes (n ¼ 5) were used.…”

Section: Cadaveric Studymentioning

confidence: 99%

Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study

Windt

Vonk

Buskermolen

et al. 2015

Osteoarthritis and Cartilage

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Section: Cadaveric Studymentioning

confidence: 99%

Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study

Windt

Vonk

Buskermolen

et al. 2015

Osteoarthritis and Cartilage

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“…Margulis et al confirmed the effect of a new inorganic hemostatic agent on the model of open and laparoscopic partial nephrectomy in pigs without the use of supportive hemostatic techniques 18. Similarly, Pick et al19 confirmed the effect of sprayed fibrin sealant.…”

Section: Discussionmentioning

confidence: 92%

Preparation and properties of phosphorylated and crosslinked poly(vinyl alcohol)/bisphenol A–epoxy resin membranes for fuel cell applications

Yuan

Liu

et al. 2011

J of Applied Polymer Sci

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To overcome the strong dependence of the conductivity on the relative humidity and the lower thermal stability at high temperature of perfluorosulfonate polymers and the leaching-out problem of phosphoric acid doped membranes, a series of phosphorylated and crosslinked poly(vinyl alcohol) (PVA)/bisphenol A-epoxy resin [diglycidyl ether of bisphenol A (DGEBA)] membranes were prepared. The membrane properties were characterized by Fourier transform infrared spectra, solubility, thermogravimetric analysis, water uptake, swelling ratio, ion-exchange capacity (IEC), small-angle X-ray scattering, and proton conductivity measurements. The results show that the crosslinked PVA/DGEBA membrane had a higher thermal stability (T d ! 250 C) than the pure PVA membrane (T d ! 220 C) and that the phosphorylated and crosslinked PVA/DGEBA membranes (IEC ¼ 5.54 mmol/g) with a low volume swelling ratio (7.21%) could achieve a maximum proton conductivity of 2.51 Â 10 À3 S/cm at a temperature as high as 150 C in anhydrous conditions V C 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: [3071][3072][3073][3074][3075][3076][3077][3078][3079] 2011

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“…Tisseel glue can withstand an arterial pressure of up to 350 mmHg before it is dislodged from renal parenchyma. 11 Patients undergoing OPNs are placed in flank position, and a supra 12th rib incision is made. The kidneys are dissected in the retroperitoneal space and the renal lesion(s) identified.…”

Section: Methodsmentioning

confidence: 99%

Laparoscopic and open partial nephrectomy: a UK centre's experience

Youssef

Smith

Oakley

2014

Journal of Clinical Urology

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Introduction: Laparoscopy allows minimally invasive approaches for procedures traditionally performed openly, with associated lower morbidity. Nephron-sparing surgery (NSS) is mostly regarded as an open procedure because laparoscopic partial nephrectomy (LPN) is technically challenging. We evaluated our centre's experience with LPN and open partial nephrectomy (OPN). Methods: All patients over five years (2005)(2006)(2007)(2008)(2009)(2010) undergoing NSS were identified retrospectively from our operating room management information system. Case notes, diagnostic and post-operative surveillance imaging were reviewed. Post-operative morbidity, histopathology and serum full blood count and urea and electrolyte reports were recorded. Results: A total of 97 OPNs and 23 LPNs were performed. Median length of stay was six days for OPNs and three days for LPNs (p = 0.005). Mean drop in haemoglobin (Hb) was 2.6 g/dl for both OPNs and LPNs. No significant difference in transfusion rates was observed. Median warm ischaemia time (WIT) for OPNs was 14 minutes and 32 minutes for LPNs (p < 0.0001). No significant difference was seen in changes from baseline serum creatinine when comparing OPNs with LPNs at day 1 (p = 0.7572) and at 12 months (p = 0.7406) post-operatively. Surgical margins were positive in 20 (21.5%) OPNs and negative in all LPNs (p = 0.038). One patient developed local recurrence following OPN (clear margins) and two patients developed distant metastases. Conclusions: Benefits of LPN include shorter hospital stay and satisfactory long-term preservation of renal function, despite longer WITs. This demonstrates the benefits of LPNs in patients with single exophytic renal tumours performed by highly experienced, regionally selected laparoscopists.

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Sprayed Fibrin Sealant as the Sole Hemostatic Agent for Porcine Laparoscopic Partial Nephrectomy

Abstract: Sprayed Tisseel without suturing effectively sealed the arterial and collecting system after severe laparoscopic partial nephrectomy in the porcine model.

Cited by 16 publications

References 19 publications

Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study

Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study

Preparation and properties of phosphorylated and crosslinked poly(vinyl alcohol)/bisphenol A–epoxy resin membranes for fuel cell applications

Laparoscopic and open partial nephrectomy: a UK centre's experience

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