Spouse-Related Drug Side-Effects

Moore, Nicholas; Paux, Gautier; Noblet, C.; Andrejak, M

doi:10.1016/s0140-6736(88)91254-8

Cited by 15 publications

(9 citation statements)

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“…Transdermal hormone transfer from dosed individual to naïve interpersonal contact can occur [36,39,42,[45][46][47] and may cause clinically significant hormone imbalance and adverse events [21][22][23][24][25][26][27][28] . Transfer from parent to young child, as has been previously described [29][30][31][32][33][34][35] , is concerning.…”

Section: Discussionmentioning

confidence: 99%

“…While transdermal delivery of estradiol and testosterone may be clinically relevant for the treated individual, unintentional transfer to a close contact can cause hormone imbalance and adverse effects. These imbalances may increase the risk of adverse cardiac events in men; cause hyperandrogenism, hirsutism, acne, coarsening of the voice, clitoris hypertrophy, and male-pattern baldness in women; and can lead to early puberty changes, virilization, and premature epiphyseal closure of the bones in children [21][22][23][24][25][26][27][28] . Cases of skin-to-skin transfer of transdermal testosterone products from father to son have caused precocious puberty and/or pronounced virilization [29][30][31][32][33][34][35] .…”

mentioning

confidence: 99%

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Transdermal Estradiol and Testosterone Transfer in Man: Existence, Models, and Strategies for Prevention

Busse

Maibach

2010

Skin Pharmacol Physiol

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Background: Transdermal hormone application allows delivery of a clinically relevant hormone dose often with fewer systemic side effects than oral formulations. However, transdermal hormone transfer from a dosed individual to naïve interpersonal contact occurs and may cause significant hormone imbalance and adverse effects. Methods: We reviewed PubMed, Medline, and Scopus articles from the years 1950 to 2010 for articles related to transdermal hormone transfer in the setting of in vivo and in vitro human and animal models. We used the following key words: transfer, transdermal, absorption, cutaneous, hormone, estradiol, and testosterone. Unpublished trials were reviewed on the US Food and Drug Administration (FDA) website for product approval. Results: Data reflecting in vivo transfer of transdermal estradiol and testosterone in man is available from case reports, clinical trials, and FDA product information. While results clearly show that transfer can occur, methods for measuring the effect are not standardized and are thus difficult to compare among positive and negative studies. No in vitro human studies or animal models have been developed to specifically examine transfer potential of transdermal estradiol or testosterone. Conclusion: It is necessary to consider the mechanism behind transdermal hormone transfer and consider ways to enhance clinical benefits to the dosed individual while minimizing transfer to a naïve interpersonal contact. A detailed discussion of trial comparisons and future optimization methods may help enhance our understanding of the potential for transdermal hormone transfer and encourage development of newer formulations and/or application methods to minimize its occurrence.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Transdermal Estradiol and Testosterone Transfer in Man: Existence, Models, and Strategies for Prevention

Busse

Maibach

2010

Skin Pharmacol Physiol

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“…In one report, in a woman whose husband was using testosterone cream for hypogonadism, excessive facial hair growth with a distinctly male pattern was observed. The man was asked to stop using the cream and hair growth stopped worsening within days (17). In other research, hirsutism development was reported in some female partners of 17 men using medroxyprogestrone acetate (oral) plus testosterone ointment for contraception.…”

Section: Discussionmentioning

confidence: 99%

A randomized, double‐blind, controlled trial of testosterone gel treatment versus vehicle control on the facial hair of young men with beta‐thalassemia major

Saeedi

Kosaryan

Fekri

et al. 2007

Journal of Dermatological Treatment

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“…514 Transdermal Testosterone. As a large amount of testosterone remains on the skin after topical application, transfer of testosterone by direct skin contact is a risk for an intimate partner [535][536][537] or for children. 152 Adhesive dermal patches and gels delivering testosterone transdermally by daily application can maintain physiologic circulating testosterone levels.…”

Section: Formulation Route and Dosementioning

confidence: 99%