Sporotrichosis

Ramos‐e‐Silva, Márcia; Vasconcelos, Camila Teixeira Moreira; Carneiro, Sueli; Cestari, Tânia Ferreira

doi:10.1016/j.clindermatol.2006.05.006

Cited by 144 publications

(149 citation statements)

References 26 publications

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“…This organism is closely related to Ophiostoma stenoceras, a non-pathogenic fungus that grows on sapwood from coniferous and hardwood trees (de Beer et al 2003). Sporotrichosis is a subcutaneous mycosis caused by traumatic inoculation of colonised materials (soil, wood, decomposed vegetable matter) or inhalation of the conidia (Ramos-e-Silva et al 2007). The disease has been reported as an emerging mycosis in HIV-infected humans (Durden & Elewski 1997).…”

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confidence: 99%

Purification and biochemica characterisation of endoplasmic reticulum α 1,2-mannosidase from Sporothrix schenckiil

Mora-Montes

Robledo-Ortiz

Gonzalez-Sanchez

et al. 2010

Mem. Inst. Oswaldo Cruz

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N-glycosylation of proteins is a common post-translational modification in eukaryotic cells. Following the translocation of nascent proteins into the endoplasmic reticulum (ER), the Glc 3 Man 9 GlcNAc 2 oligosaccharide is transferred to asparagine residues and sequentially processed by ER α-glucosidases, which remove the three glucose residues and by α-mannosidases that trim at least one mannose residue (Kornfeld & Kornfeld 1985, Herscovics 1999a.Alpha-mannosidases are grouped within families 38 and 47 of the glycosyl hydrolase classification (Henrissat 1991, Henrissat & Davies 1997. Members of family 38 are less specific than enzymes from family 47, removing α1,2, α1,3 and α1,6-linked mannose units (Daniel et al. 1994, Herscovics 1999a. Enzymes from family 47 are α1,2-mannosidases that participate in the trimming of N-glycans and in ER-associated degradation (Herscovics 1999a, b, 2001, Helenius & Aebi 2004. Two subgroups of enzymes comprise family 47: the ER α1,2-mannosidases that trim only one mannose residue from Man 9 GlcNAc 2 (M 9 ) generating Man 8 GlcNAc isomer B (M 8 B) (Ziegler & Trimble 1991, Tremblay & Herscovics 1999, Mora-Montes et al. 2004, Movsichoff et al. 2005; and Golgi α1,2-mannosidases from mammalian cells and filamentous fungi, which act after the ER enzyme to remove three α1,2-linked mannose units, generating Man 5 GlcNAc 2 , an intermediate required for the biosynthesis of complex and hybrid N-glycans (Yoshida et al. 1993, Lal et al. 1998, Ichishima et al. 1999, Eades & Hintz 2000, Tremblay & Herscovics 2000, Lobsanov et al. 2002, Akao et al. 2006. Lower eukaryotes, such as Saccharomyces cerevisiae, lack Golgi α1,2-mannosidases and synthesise only high-mannose N-glycans (Herscovics 1999b).Sporothrix schenckii, the etiological agent of sporotrichosis, is a dimorphic fungus that grows as filamentous and yeast cells during saprophytic and parasitic phases, respectively. This organism is closely related to Ophiostoma stenoceras, a non-pathogenic fungus that grows on sapwood from coniferous and hardwood trees (de Beer et al. 2003). Sporotrichosis is a subcutaneous mycosis caused by traumatic inoculation of colonised materials (soil, wood, decomposed vegetable matter) or inhalation of the conidia (Ramos-e-Silva et al. 2007). The disease has been reported as an emerging mycosis in HIV-infected humans (Durden & Elewski 1997). The cell wall of S. schenckii is being actively researched, as this structure has an important role in adhesion to host tissues and is the main source of antigens that can be exploited in the immuno-diagnosis of the disease (LopesBezerra et al. 2006). The cell wall of S. schenckii contains β1,3, β1,6 and β1,4-glucans (Lopes-Bezerra et al. In order to gain insight into the processing steps of Nglycan biosynthesis, a membrane-bound α-mannosidase from S. schenckii was targeted for purification and characterisation. Biochemical characterisation and intracellular localisation studies indicated that this enzyme is an ER α1,2-mannosidase and therefore a new member of glycosyl hydrol...

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confidence: 99%

Purification and biochemica characterisation of endoplasmic reticulum α 1,2-mannosidase from Sporothrix schenckiil

Mora-Montes

Robledo-Ortiz

Gonzalez-Sanchez

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…1 The disseminated cutaneous presentation of sporotrichosis has been observed mainly in immunocompromised patients, especially HIV positive ones. Extra cutaneous clinical presentations such as pulmonary, osteoarticular, ocular, and meningitis are rare.…”

Section: Discussionmentioning

confidence: 99%

“…The disease is sometimes classified as an occupational hazard and professionals like florists, horticulturists, gardeners and miners have a higher risk of getting infected. 1,6 Other forms of contamination include inhalation of the fungus and zoonotic transmission through scratches or bites from domestic animals, mostly cats.…”

Section: Discussionmentioning

confidence: 99%

“…The growth of the colonies can be seen in 30 days. 1 The media BHI Agar can be used to identify the thermal dimorphism. 2 The histopathological examination is not specific; however it is a useful tool to diagnosis by showing the pseudoepitheliomatous hyperplasia and the granulomatous reaction, which can harbor microabscesses within.…”

Section: Discussionmentioning

confidence: 99%

“…The disease is considered by some authors as occupational. 1 The number of cases of zoonotic transmission has been increasing significantly, with a recent report of an epidemic outbreak with documented zoonotic transmission by infected cats in Rio de Janeiro, south east of Brazil. 2 In this paper we report the occurrence of simultaneous cases of sporotrichosis in three members of the same family, where the source of infection was a domestic cat.…”

Section: Introductionmentioning

confidence: 99%

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Ocorrência familiar de esporotricose zoonótica

Cordeiro

Bruno

Paula

et al. 2011

An. Bras. Dermatol.

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Abstract:Sporotrichosis is a suba cu te or chro nic myco sis cau sed by the dimor phic fun gus Sporothrix schenc kii which is ende mic in Brazil and is trans mit ted pri ma rily through trau ma tic ino cu la tion of its causa ti ve agent into the skin. The zoo no tic trans mis sion, espe cially from infec ted cats, has been demons trated in seve ral reports and case series. We pre sent simul ta neous occur ren ce of the disea se in three members of the same family by scrat ches from an infec ted domes tic cat. Two patients deve lo ped the lympho cuta neous form and one only deve lo ped the fixed cuta neous form. Two patients were suc cess fully trea ted with satu ra ted solu tion of potas sium iodi de; howe ver, the third case repor ted side effects and had his therapy subs ti tu ted for itra co na zo le, with reso lu tion of his lesions. Keywords: Cats; Disease trans mis sion, infec tious; Potassium iodi de; Sporotrichosis Resumo: A espo ro tri co se é mico se suba gu da ou crô ni ca, cau sa da pelo fungo dimór fi co Sporothrix schenckii, endê mi ca no Brasil e trans mi ti da prin ci pal men te atra vés da ino cu la ção trau má ti ca de seu agen te cau sal na pele. A trans mis são zoo nó ti ca, espe cial men te por gatos infec ta dos, tem sido demons tra da em diver sos rela tos e séries de casos. Nós des cre ve mos a ocor rên cia simul tâ nea da doen ça em três mem bros de uma mesma famí lia atra vés da arra nha du ra por gato domés ti co infec ta do. Dois pacien tes desen vol ve ram a forma cutâ nea-lin fá ti ca e ape nas um desen vol veu a forma cutâ nea fixa. Dois pacien tes foram tra ta dos com sucesso, com solu ção satu ra da de iode to de potás sio; entre tan to, o ter cei ro caso apre sen tou efei tos cola te rais e teve seu tra ta men to subs ti tuí do por itra co na zol, com reso lu ção de suas lesões. Palavras-chave: Esporotricose; Gatos; Iodeto de potás sio; Transmissão de doen ça infec cio sa

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Sporotrichosis

2012

Fungal Infection

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Sporotrichosis

Cited by 144 publications

References 26 publications

Purification and biochemica characterisation of endoplasmic reticulum α 1,2-mannosidase from Sporothrix schenckiil

Purification and biochemica characterisation of endoplasmic reticulum α 1,2-mannosidase from Sporothrix schenckiil

Ocorrência familiar de esporotricose zoonótica

Sporotrichosis

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