Spontaneous Retinal Degeneration in Mature Osborne-Mendel Rats

Nervous System and Special Sense Organs

“…167 Hereditary retinal degeneration has been well characterized in a number of rat strains, notably the Royal College of Surgeons (RCS) strain and the Wag/Rij rat. 385 In the Wag/Rij there appears to be a primary degeneration of the photoreceptor cell body starting at about one month of age and within a period of one year this led to total loss of outer retinal cells. It has been shown that a mutation of the c-mer proto-oncogene tyrosine-protein kinase (mertk), an enzyme that in humans is encoded by the MERTK gene, underlies the retinal pathology.…”

Nervous System and Special Sense Organs

“…167 Hereditary retinal degeneration has been well characterized in a number of rat strains, notably the Royal College of Surgeons (RCS) strain and the Wag/Rij rat. 385 In the Wag/Rij there appears to be a primary degeneration of the photoreceptor cell body starting at about one month of age and within a period of one year this led to total loss of outer retinal cells. It has been shown that a mutation of the c-mer proto-oncogene tyrosine-protein kinase (mertk), an enzyme that in humans is encoded by the MERTK gene, underlies the retinal pathology.…”

Ocular disease in rats: a review

“…Interestingly, even in strains with a defined inherited trait, light has a significant effect. In the RCS rat, discussed further below, environmental light levels have a profound effect on the rate of degenerative change, dark‐reared animals having significantly less severe and more protracted degenerative processes than those kept in the light 68 …”

Mechanisms of retinal photoreceptor loss in spontaneously hypertensive rats

“…Spontaneously hypertensive rats (SHR), which have higher blood pressure compared to their strain of origin, Wistar Kyoto (WKY) rats, are commonly used as an in vivo experimental model for hypertensive diseases, including hypertensive retinopathy ( Eshaq et al, 2023 ; Leskova et al, 2020 ). In an early study of SHR, von Sallmann and Grimes found retinal degeneration in SHR compared to WKY rats ( von Sallmann and Grimes, 1974 ), and chronic hypertension has been reported to be associated with reduced retinal function in SHR ( Cui et al, 2022 ). While these retinal dysfunctions are thought to be caused by high blood pressure ( von Sallmann and Grimes, 1974 ), the exact pathological mechanisms remain unclear.…”

“…In an early study of SHR, von Sallmann and Grimes found retinal degeneration in SHR compared to WKY rats ( von Sallmann and Grimes, 1974 ), and chronic hypertension has been reported to be associated with reduced retinal function in SHR ( Cui et al, 2022 ). While these retinal dysfunctions are thought to be caused by high blood pressure ( von Sallmann and Grimes, 1974 ), the exact pathological mechanisms remain unclear. This study aims to confirm the retinal changes in SHR and elucidate the underlying pathologies of retinal neurodegeneration in SHR compared to WKY rats.…”

Nervous System and Special Sense Organs

“…167 Hereditary retinal degeneration has been well characterized in a number of rat strains, notably the Royal College of Surgeons (RCS) strain and the Wag/Rij rat. 385 In the Wag/Rij there appears to be a primary degeneration of the photoreceptor cell body starting at about one month of age and within a period of one year this led to total loss of outer retinal cells. It has been shown that a mutation of the c-mer proto-oncogene tyrosine-protein kinase (mertk), an enzyme that in humans is encoded by the MERTK gene, underlies the retinal pathology.…”

Ocular disease in rats: a review

“…Interestingly, even in strains with a defined inherited trait, light has a significant effect. In the RCS rat, discussed further below, environmental light levels have a profound effect on the rate of degenerative change, dark‐reared animals having significantly less severe and more protracted degenerative processes than those kept in the light 68 …”

Mechanisms of retinal photoreceptor loss in spontaneously hypertensive rats

“…Spontaneously hypertensive rats (SHR), which have higher blood pressure compared to their strain of origin, Wistar Kyoto (WKY) rats, are commonly used as an in vivo experimental model for hypertensive diseases, including hypertensive retinopathy ( Eshaq et al, 2023 ; Leskova et al, 2020 ). In an early study of SHR, von Sallmann and Grimes found retinal degeneration in SHR compared to WKY rats ( von Sallmann and Grimes, 1974 ), and chronic hypertension has been reported to be associated with reduced retinal function in SHR ( Cui et al, 2022 ). While these retinal dysfunctions are thought to be caused by high blood pressure ( von Sallmann and Grimes, 1974 ), the exact pathological mechanisms remain unclear.…”

“…In an early study of SHR, von Sallmann and Grimes found retinal degeneration in SHR compared to WKY rats ( von Sallmann and Grimes, 1974 ), and chronic hypertension has been reported to be associated with reduced retinal function in SHR ( Cui et al, 2022 ). While these retinal dysfunctions are thought to be caused by high blood pressure ( von Sallmann and Grimes, 1974 ), the exact pathological mechanisms remain unclear. This study aims to confirm the retinal changes in SHR and elucidate the underlying pathologies of retinal neurodegeneration in SHR compared to WKY rats.…”

Nervous System and Special Sense Organs

“…167 Hereditary retinal degeneration has been well characterized in a number of rat strains, notably the Royal College of Surgeons (RCS) strain and the Wag/Rij rat. 385 In the Wag/Rij there appears to be a primary degeneration of the photoreceptor cell body starting at about one month of age and within a period of one year this led to total loss of outer retinal cells. It has been shown that a mutation of the c-mer proto-oncogene tyrosine-protein kinase (mertk), an enzyme that in humans is encoded by the MERTK gene, underlies the retinal pathology.…”

Ocular disease in rats: a review

“…Interestingly, even in strains with a defined inherited trait, light has a significant effect. In the RCS rat, discussed further below, environmental light levels have a profound effect on the rate of degenerative change, dark‐reared animals having significantly less severe and more protracted degenerative processes than those kept in the light 68 …”

Mechanisms of retinal photoreceptor loss in spontaneously hypertensive rats

“…Spontaneously hypertensive rats (SHR), which have higher blood pressure compared to their strain of origin, Wistar Kyoto (WKY) rats, are commonly used as an in vivo experimental model for hypertensive diseases, including hypertensive retinopathy ( Eshaq et al, 2023 ; Leskova et al, 2020 ). In an early study of SHR, von Sallmann and Grimes found retinal degeneration in SHR compared to WKY rats ( von Sallmann and Grimes, 1974 ), and chronic hypertension has been reported to be associated with reduced retinal function in SHR ( Cui et al, 2022 ). While these retinal dysfunctions are thought to be caused by high blood pressure ( von Sallmann and Grimes, 1974 ), the exact pathological mechanisms remain unclear.…”

“…In an early study of SHR, von Sallmann and Grimes found retinal degeneration in SHR compared to WKY rats ( von Sallmann and Grimes, 1974 ), and chronic hypertension has been reported to be associated with reduced retinal function in SHR ( Cui et al, 2022 ). While these retinal dysfunctions are thought to be caused by high blood pressure ( von Sallmann and Grimes, 1974 ), the exact pathological mechanisms remain unclear. This study aims to confirm the retinal changes in SHR and elucidate the underlying pathologies of retinal neurodegeneration in SHR compared to WKY rats.…”