Spontaneous Resolution of a Central Giant-Cell Granuloma After Incisional Biopsy: A Case Report

Berti, Soraya A; Souza, Paulo Henrique Couto; Jacobs, Reinhilde; Lambrichts, Ivo; Corpas, Livia; Arruda, Elcy Pinto de; Martins, Wilson; Westphalen, Fernando Henrique; Tolazzi, Ana Lúcia

doi:10.1016/j.joms.2008.12.053

Cited by 9 publications

(2 citation statements)

References 21 publications

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“…Occasional articles over the years do appear to have confirmed this, particularly after biopsy. [6] We ourselves have seen the occasional lesion of this type resolve spontaneously, and this is shown in [Figure 1] where a 23-year-old Caucasian female patient had biopsy only for this lesion and never had any definitive treatment carried out. The lesion resolved over an 18-month period.…”

Section: Introductionmentioning

confidence: 98%

The diagnosis and management of giant cell lesions of the jaws

Pogrel

2012

Ann Maxillofac Surg

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This article will review current thoughts with regard to the etiology, histopathology, diagnosis, and management of giant cell lesions of the jaws. It will attempt to point out the differences between these lesions and giant cell lesions elsewhere in the body and also the current techniques for medical management of these conditions including steroid injections, calcitonin treatment, and alpha interferon treatment.

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Section: Introductionmentioning

confidence: 98%

The diagnosis and management of giant cell lesions of the jaws

Pogrel

2012

Ann Maxillofac Surg

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“…El granuloma central de células gigantes (GCCG) es una lesión intraósea de la parte anterior o posterior de la mandíbula y el maxilar, que en casos de gran tamaño expande las tablas corticales, causa desplazamiento, de los dientes y produce reabsorción radicular; está compuesto por células gigantes en un fondo de células fibrohistiocíticas, mononucleares y eritrocitos (2,3). Se caracteriza por afectar principalmente al maxilar inferior en zonas posteriores de arcadas dentarias, aunque también puede aparecer en sectores anteriores, especialmente en jóvenes con promedio de edad 2 a 30 años, afectando más al sexo femenino (4,5).…”

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Consideraciones sobre el granuloma central de células gigantes

Pallares

Herrera

Caballero

2014

Cienc. Salud virtual

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El granuloma central de células gigantes (GCCG) es un proceso circunscrito, endofítico poco frecuente de la cavidad oral, también denominada épulis de células gigantes, osteoclastoma, granuloma reparativo de células gigantes, o hiperplasia de células gigantes, la mayor parte de las veces se desarrolla de manera asintomática y se detecta como un hallazgo radiográfico o por la expansión indolora del hueso afectado. En algunos casos se presenta con un comportamiento más agresivo, asociado a dolor, parestesia, perforación de corticales óseas e incluso ulceración de la mucosa. Siempre se debe realizar diagnóstico diferencial, enfocando sobre todo tres de ellos el tumor pardo del hiperparatiroidismo, el querubismo y el quiste óseo aneurismático. Se presenta caso clínico en paciente masculino de 14 años de edad, con diagnóstico de GCCG a nivel de molares inferiores derechos, el cual después de realizarse curetaje, presentó posterior recidiva de la lesión a los seis meses, por lo que se realiza hemimandibulectomía y colocación de placa de reconstrucción mandibular en titanio sistema Marx. Se plantea el caso con el propósito de evitar nueva recidiva de la lesión, logrando éxito con el tratamiento empleado, observando ausencia clínica y radiográfica de signos de recurrencia.

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Central giant cell granuloma: treatment with calcitonin, triamcinolone acetonide, and a cystic finding 3 years and 6 months after the primary treatment

Sampieri

Yaedú

Santos

et al. 2012

Oral Maxillofac Surg

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Due to the diagnosis and the age of the patient, we chose a conservative treatment, administering subcutaneous injections of calcitonin. During this treatment, no reduction to the lesion was observed. Therefore, we chose to treat the lesion with triamcinolone acetonide. Monthly follow-ups demonstrated good lesion reduction and the absence of any clinical symptoms during the first 2 years. After a 3-year follow-up, the patient returned, presenting mobility of the lower incisors. A significant increase in the size of the lesion was observed. After a biopsy, with the removal of tissue which had the appearance of a cyst capsule, microscopic analyses were found to be compatible with a secondarily infected cyst. Two months following this procedure, the patient did not present tooth mobility anymore and the oral mucosa presented a normal aspect. Following a radiographic exam, full lesion repair was observed. These conservative treatments should be the first option in cases of central giant cell granuloma and the patient must be observed for a long period of time, until no further clinical or radiographic signs of lesions are observed.

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Spontaneous Resolution of a Central Giant-Cell Granuloma After Incisional Biopsy: A Case Report

Cited by 9 publications

References 21 publications

The diagnosis and management of giant cell lesions of the jaws

The diagnosis and management of giant cell lesions of the jaws

Consideraciones sobre el granuloma central de células gigantes

Central giant cell granuloma: treatment with calcitonin, triamcinolone acetonide, and a cystic finding 3 years and 6 months after the primary treatment

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