Spontaneous pregnancy following cytoreduction with peritonectomy and hyperthermic intraperitoneal chemotherapy

Kyser, Kathy L.; Bidus, Michael A.; Rodríguez, M. Vázquez; Rose, G. Scott; Elkas, John C.

doi:10.1016/j.ygyno.2005.08.045

Cited by 14 publications

(7 citation statements)

References 11 publications

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“…In the case of obvious ovarian invasion, ovarian sparing surgery must include preoperative counseling and informed consent [4]. In the case of extensive peritonectomy, ovarian sparing does not prevent postoperative adhesions potentially responsible for impaired tubal motility and subsequent infertility [47]. The role of HIPEC is difficult to clarify despite several studies showing that pregnancies following CRS-HIPEC is feasible and probably underestimated [41,47].…”

Section: Discussionmentioning

confidence: 99%

“…In the case of extensive peritonectomy, ovarian sparing does not prevent postoperative adhesions potentially responsible for impaired tubal motility and subsequent infertility [47]. The role of HIPEC is difficult to clarify despite several studies showing that pregnancies following CRS-HIPEC is feasible and probably underestimated [41,47]. That suggests that heat and drug toxicities on ovarian function are relatively low.…”

Section: Discussionmentioning

confidence: 99%

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Multicystic peritoneal mesothelioma treated with cytoreductive surgery followed or not by hyperthermic intraperitoneal chemotherapy: results from a large multicentric cohort

Képénékian

Péron

Goèré

et al. 2021

International Journal of Hyperthermia

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Background: Multicystic peritoneal mesothelioma (MCPM) is a rare, slowly growing, condition prone to recur after surgery. The role of hyperthermic intraperitoneal chemotherapy (HIPEC) added to complete cytoreductive surgery (CRS) remains controversial and difficult to assess. As patients are mostly reproductive age women, surgical approach, and fertility considerations are important aspects of the management. This observational retrospective review aimed to accurate treatment strategy reflections. Methods: The RENAPE database (French expert centers network) was analyzed over a 1999-2019 period. MCPM patients treated with CRS were included. A special focus on HIPEC, mini-invasive approach, and fertility considerations was performed. Results: Overall 60 patients (50 women) were included with a median PCI of 10 (4-14) allowing 97% of complete surgery, followed by HIPEC in 82% of patients. A quarter of patients had a laparoscopic approach. Twelve patients (20%) recurred with a 3-year recurrence free survival of 84.2% (95% confidence interval 74.7-95.0). The hazard of recurrence was numerically reduced among patients receiving HIPEC, however, not statistically significant (hazard ratio 0.41, 0.12-1.42, p ¼ 0.200). A severe postoperative adverse event occurred in 22% of patients with five patients submitted to a subsequent reoperation. Among four patients with a childbearing desire, three were successful (two had a laparoscopic-CRS-HIPEC and one a conventional CRS without HIPEC). Conclusion: MCPM patients treatment should aim at a complete CRS. The intraoperative treatment options as laparoscopic approach, fertility function sparing and HIPEC should be discussed in expert centers to propose the most appropriate strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multicystic peritoneal mesothelioma treated with cytoreductive surgery followed or not by hyperthermic intraperitoneal chemotherapy: results from a large multicentric cohort

Képénékian

Péron

Goèré

et al. 2021

International Journal of Hyperthermia

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“…In light of increased long term survival and cure, future fertility should be considered for reproductiveaged women with DMPM prior to initiation of CRS and HIPEC treatment [10]. Options for future fertility are dependent upon the acuity of the disease and timely access to advanced reproductive technologies, along with the cost of oocyte and embryo cryopreservation.…”

Section: Discussionmentioning

confidence: 99%

In vitro fertilization pregnancy following treatment of diffuse malignant peritoneal mesothelioma

Assis¹,

Saunders²

2019

J Case Rep Images Gynecol Obstet

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Introduction: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare aggressive neoplasm. Cytoreductive surgery (CRS) and hyperthermic intraoperative peritoneal perfusion chemotherapy (HIPEC) increased overall survivals but the impact on women's fertility after treatment is unknown. Case Report: A 28-year-old with primary infertility and recurrent ascites was diagnosed with epithelioid subtype DMPM. Ovarian suppression was achieved with a GnRH-agonist prior to treatment. Two years after remission, she underwent invitro fertilization (IVF) and delivered a healthy female infant at term. Conclusion: Patients with DMPM have a 50% survival at five years with CRS and HIPEC. We report the rare case of a live birth achieved with IVF following CRS and HIPEC treatment for DMPM. Pre-chemotherapy GnRH

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“…Chemotherapeutic agents have a direct cytotoxic eff ect on the ovaries, which may result in premature ovarian failure and, thus, infertility. To date, very few cases of pregnancy aft er IPHC have been documented in literature (Kyser et al 2006). Th e administration of IPHC might control growth of peritoneal disease.…”

Section: Discussionmentioning

confidence: 99%

Infiltrating mucinous appendicular carcinoma during pregnancy. A case report and review of the literature

Chiverto

Cabezas

Pérez-Medina

et al. 2015

Journal of Obstetrics and Gynaecology

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Spontaneous pregnancy following cytoreduction with peritonectomy and hyperthermic intraperitoneal chemotherapy

Cited by 14 publications

References 11 publications

Multicystic peritoneal mesothelioma treated with cytoreductive surgery followed or not by hyperthermic intraperitoneal chemotherapy: results from a large multicentric cohort

Multicystic peritoneal mesothelioma treated with cytoreductive surgery followed or not by hyperthermic intraperitoneal chemotherapy: results from a large multicentric cohort

In vitro fertilization pregnancy following treatment of diffuse malignant peritoneal mesothelioma

Infiltrating mucinous appendicular carcinoma during pregnancy. A case report and review of the literature

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