Spontaneous pneumothorax without any detectable pulmonary metastases in a patient with osteosarcoma

Yamamoto, Toshiyuki; Mizuno, Kosaku

doi:10.1007/s002640050394

Cited by 8 publications

(4 citation statements)

References 5 publications

(4 reference statements)

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“…Patients with osteosarcoma that have pulmonary metastases have a higher risk of spontaneous pneumothorax than patients with pulmonary metastatic carcinoma, but the reason for this remains unclear (8). It is also unclear whether there is any correlation between pneumothorax and lung metastasis (9). Regardless of whether patients with osteosarcoma have pulmonary metastases, those who receive chemotherapy have a higher risk of spontaneous pneumothorax than those who do not (8).…”

Section: Discussionmentioning

confidence: 76%

Bilateral spontaneous pneumothorax in an osteosarcoma patient with pulmonary metastases: A case report

et al. 2015

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Abstract. Spontaneous pneumothorax is a rare complication of chemotherapy in the treatment of lung neoplasms. It is relatively common in osteosarcoma lung metastases patients following chemotherapy, but the cause is still unknown. Here, we report a case of bilateral spontaneous pneumothorax occurring in a 40-year-old female in whom lung metastases from osteosarcoma were treated with combination chemotherapy. The patient had osteosarcoma on the right side of the mandible, and developed bilateral spontaneous pneumothorax. Through contrasting chest computed tomography, pneumothorax was identified at the site of the pulmonary metastases and occurred following the formation of bullae. The pneumothorax and bullae were produced after the patient received chemotherapy. In October 2014, the patient succumbed to the disease due to hemorrhage of the primary osteosarcoma lesions. IntroductionSpontaneous pneumothorax in patients with osteosarcoma is a well-known phenomenon. It occurs as a complication of pulmonary metastases of osteosarcoma or during chemotherapy. Pneumothorax is a clinical emergency (1,2). The incidence rate of the pneumothorax in osteosarcoma patients is extremely low; spontaneous pneumothorax occurs in <2% of patients with pulmonary metastases (3). Pneumothorax affects respiratory function and endangers patient life by interfering with the treatment of osteosarcoma. Subsequently, pneumothorax significantly decreases quality of life and increases the risk of mortality in osteosarcoma patients (4). It reported that <10% of sarcoma patients with spontaneous pneumothorax survive for >2 years following the initial diagnosis of pneumothorax (5).Surgical resection is considered the best treatment for this complication (3). Here, we present a case of bilateral spontaneous pneumothorax with pulmonary metastases. We observed that pneumothorax developed after the formation of bullae through chest computed tomography (CT). In addition, all of these events occurred after the patient had received chemotherapy. Written informed consent was obtained from the patient's family. Case reportA 40-year-old female presented with right lower lip numbness in 2007 and a mass was identified on the right mandibular area in April 2008. CT revealed right mandibular body bone destruction and a soft tissue mass. Following resection of the right mandible, osteosarcoma was revealed by biopsy. The right mandible osteosarcoma relapsed in February 2009. Following surgery, the patient was treated with four cycles of dacarbazine + ifosfamide + epirubicin. However, the osteosarcoma relapsed once more in June 2013. In September of the same year bilateral pulmonary metastases was confirmed by CT. The patient was then treated with one cycle of adriamycin (ADM) and cisplatin (DDP). Chest CT revealed left liquid pneumothorax on 12 December 2013. Following tube drainage therapy, the left liquid pneumothorax was cured and another cycle of ADM + DDP was administered. The patient suffered from severe anemia and thus, chemotherapy could not be applied re...

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Section: Discussionmentioning

confidence: 76%

Bilateral spontaneous pneumothorax in an osteosarcoma patient with pulmonary metastases: A case report

et al. 2015

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“…Can SPx alert us of any coming metastasis ? There are two osteosarcoma cases with pneumothorax who have developed metastasis during follow-up (3,25). In some of the cases, there were no metastatic foci or evidence of disease, although SPx has developed (24).…”

Section: Discussionmentioning

confidence: 95%

Spontaneous Pneumothorax in Children with Osteosarcoma: Report of Three Cases and Review of the Literature

Fayda

Kebudi

Dizdar

et al. 2012

Acta Chirurgica Belgica

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Spontaneous pneumothorax is a rare manifestation of primary lung cancer or metastasis. It is estimated that < 1% of all cases of spontaneous pneumothorax are tumor-associated and metastatic osteogenic or soft-tissue sarcomas are associated most commonly with pneumothorax especially in the setting of cytotoxic chemotherapy or radiotherapy. In this article, we report three pediatric cases with osteosarcoma that developed spontaneous pneumothorax during chemotherapy with a review of the literature. Two of them had lung metastasis at the time of the detection of pneumothorax and the remaining patient was found to have a bronchopleural fistula. SPx is an emergency situation and early diagnosis and management can improve prognosis and quality of life of the patient however the optimal management has yet to be determined.

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“…Finally, infiltration of a pre-existing benign cysts may be responsible for the development of a solution of continuity of the visceral pleura. 1,19…”

Section: Discussionmentioning

confidence: 99%

Bilateral pneumothorax after general anesthesia in patient with pleomorphic sarcoma of soft tissue

Gianesello

Boccaccini

Rostagno

2019

SAGE Open Medical Case Reports

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The occurrence of a pneumothorax using supraglottic device is a rare complication during general anesthesia. Moreover, less than 2% of pneumothoraxes can be related to lung metastases, most due to soft tissue sarcoma. We present the case of a 45-year-old female diagnosed with metastatic sarcoma who developed a bilateral pneumothorax after general anesthesia with supraglottic device. Different causes of pneumothorax were discussed.

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Spontaneous pneumothorax without any detectable pulmonary metastases in a patient with osteosarcoma

Cited by 8 publications

References 5 publications

Bilateral spontaneous pneumothorax in an osteosarcoma patient with pulmonary metastases: A case report

Bilateral spontaneous pneumothorax in an osteosarcoma patient with pulmonary metastases: A case report

Spontaneous Pneumothorax in Children with Osteosarcoma: Report of Three Cases and Review of the Literature

Bilateral pneumothorax after general anesthesia in patient with pleomorphic sarcoma of soft tissue

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