Spontaneous perforation of jejunal gastrointestinal stromal tumor: A case report

Al-Swaiti, Ghassan T.; Al-Qudah, Mohammad H.; Al-doud, Mohammad A.; Al-Bdour, Alaa R.; Al-Nizami, Walid

doi:10.1016/j.ijscr.2020.06.088

Cited by 6 publications

(11 citation statements)

References 9 publications

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“…GIST is the most common mesenchymal neoplasm of the gastrointestinal system that occurs in adults more than 40 years of age, where they peak between 60 and 65 years. Males are affected more than females without any geographic or ethnic relation (2). About 60-70% of GISTs occur in the stomach, 25-35% in the small intestine, and 10% in the jejunum (6).…”

Section: Discussionmentioning

confidence: 99%

“…According to morphology, there are three types of tumor cells: spindle cell type (70%), epithelioid cell type (20%), and mixed cell type (10%). Almost all of the GISTs are positive for c-kit (CD117) and DOG1, and 60-70% are positive for CD34 on immunohistochemistry (2,18). Further, 30-40% of GISTs are positive for SMA, 10% positive for vimentin, and 5% positive for S100 protein (19,20).…”

Section: Discussionmentioning

confidence: 99%

“…GIST is a benign tumor in 70-80% of cases. GIST arises most commonly from the stomach (60-70%), followed by the small intestine (20-25%), colon, rectum, esophagus, appendix, omentum, and retroperitoneum (2). Metastatic GIST was found in nearly 50% of cases, with the most common site of metastasis in the liver (65%) followed by the peritoneum (21%) and lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Acute Abdomen Caused by Perforation of Jejunal Gastrointestinal Stromal Tumor (Gist): A Case Report and Literature Review

Mirovic¹,

Stojanovic

Stanković

et al. 2022

Preprint

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Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal system and it accounts for between 1-3% of all gastrointestinal malignancies. GIST arises most commonly from the stomach in 60 – 70% of cases. The clinical presentation of acute abdomen, due to GIST perforation, was a particularly rare described complication of this disease. Our case report aimed to present a case of acute abdomen in an elderly female patient, due to jejunal GIST perforation. Case presentation: A 76-year-old female patient presented with acute abdomen to the emergency surgical unit University Clinical Center of Kragujevac. Computed tomography (CT) scan with intravenous contrast showed pneumoperitoneum, the presence of a 75 x 35 mm irregular fluid collection in the left lower quadrant of the abdomen with air inclusions and signs of small intestine perforations. The patient underwent an emergency laparotomy. Intraoperative findings showed the acute inflammatory reaction of the peritoneum with free bowel contents in the abdominal cavity due to jejunal tumor perforation. Partial resection of the small intestine with tumor was performed followed by intestine anastomosis. Histopathological examination of a specimen revealed a completed resected jejunal gastrointestinal stromal tumor. CONCLUSIONS: GIST arises from the small intestine in 25-30% of cases, and jejunum in 10% of cases. Perforation of GIST and acute diffuse peritoneal inflammation was rare complication of the disease. Emergency laparotomy and complete resection of tumors are essential.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Acute Abdomen Caused by Perforation of Jejunal Gastrointestinal Stromal Tumor (Gist): A Case Report and Literature Review

Mirovic¹,

Stojanovic

Stanković

et al. 2022

Preprint

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“…Gastrointestinal stromal tumors (GISTs) are the primary mesenchymal neoplasms of the gastrointestinal system, representing 1-3% of all gastrointestinal cancers [1][2][3]. Believed to originate from Cajal's cells, crucial for regulating gastrointestinal motility, these tumors predominantly appear in the stomach (60-70%) and, to a lesser extent, in the small intestine (20-25%) [1,4,5]. They are less frequently found in areas like the colon, rectum, and esophagus [1,4].…”

Section: Introductionmentioning

confidence: 99%

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature

Mirovic,

Stojanovic,

Jovanovic

et al. 2024

CIMB

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This case report details a rare instance of a perforated jejunal gastrointestinal stromal tumor (GIST) in a 76-year-old female patient. The patient presented with acute abdominal pain and distension without any changes in bowel habits or episodes of nausea and vomiting. Initial diagnostics, including abdominal plain radiography and ultrasonography, were inconclusive; however, a computed tomography (CT) scan revealed pneumoperitoneum and an irregular fluid collection suggestive of small intestine perforations. Surgical intervention uncovered a 35 mm jejunal GIST with a 10 mm perforation. Histopathological examination confirmed a mixed cell type GIST with high malignancy potential, further substantiated by immunohistochemistry markers CD117, DOG1, and vimentin. Molecular analysis illuminated the role of key oncogenes, primarily KIT and PDGFRA mutations, emphasizing the importance of molecular diagnostics in GIST management. Despite the severity of the presentation, the patient’s postoperative recovery was favorable, highlighting the effectiveness of prompt surgical and multidisciplinary approaches in managing complex GIST cases.

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“…acute abdomen) [1] . In jejunal GISTs, they can present with a palpable mass or symptoms secondary to obstruction, seldom necrosis or ulceration followed by perforation [4] , [5] , [6] , [7] , [8] .…”

Section: Introductionmentioning

confidence: 99%

Acute abdomen secondary to perforated jejunal gastrointestinal stromal tumor and imatinib-related isolated pericardial effusion in a 50-year-old female patient: A case report and review of literature

Aldosari¹,

Azzam²,

Almaiman³

et al. 2023

International Journal of Surgery Case Reports

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Spontaneous perforation of jejunal gastrointestinal stromal tumor: A case report

Abstract: Highlights GIST is rare and its presentation as spontaneous rupture is extremely rare. GIST preoperative diagnosis remains difficult. Local excision of the GIST associated with the use of imatinib is effective. GIST is a rare pathological condition.

Cited by 6 publications

References 9 publications

A Rare Case of Acute Abdomen Caused by Perforation of Jejunal Gastrointestinal Stromal Tumor (Gist): A Case Report and Literature Review

A Rare Case of Acute Abdomen Caused by Perforation of Jejunal Gastrointestinal Stromal Tumor (Gist): A Case Report and Literature Review

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature

Acute abdomen secondary to perforated jejunal gastrointestinal stromal tumor and imatinib-related isolated pericardial effusion in a 50-year-old female patient: A case report and review of literature

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