Spontaneous patterning and nanoparticle encapsulation in carboxymethylcellulose/alginate/dextran hydrogels and sponges

e preparation of gels by charge interaction methods has been extensively studied, but it is not yet clear how these methods influence gel characteristics. e objective of this work was to study differences in morphology and surface charge of hydrogels prepared by ionotropic gelation, polyelectrolyte complexation, and a combination of both methods. us, the anionic charge was provided by carboxymethylcellulose (CMC), carboxymethylated starch (CMS), and alginic acid (AA); calcium chloride (CaCl 2 ) and chitosan (CS) were used for the ionotropic gelation and polyelectrolyte complexation, respectively. ose materials are commercially available, have low toxicity, and are widely used in the area. ese compounds interact through physical crosslinks, which are affected by physical changes of the medium. Our results showed that these two methods produced changes in the morphology of the hydrogels. CMC gels exhibited larger pores in the presence of CaCl 2 . In polyelectrolyte complexation, CMS produced an increased agglomeration of particles, while the addition of CaCl 2 to AA generated dispersed particles of size in the order of millimeters. Mixing both ionotropic gelation and polyelectrolyte complexation methods yielded gels of varied charge (568 mV for CMC, 502 mV for CMS, and 1713 mV for AA). FTIR spectra of the hydrogels showed interactions between the different polymeric compounds, being the greatest changes between 1250 and 1600 cm −1 , due possibly to the replacement of Na by Ca at crosslinking points. erefore, the method of gel preparation employed had a major influence on the size and pore distribution, parameters which in turn influence encapsulation and drug delivery in these systems.

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“…Also, the same anionic polymers have been used with CaCl 2 (ionotropic gelation) [11,12] or a mix of polymers with the salt [13,14].…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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“…The compressive strength was determined by crushing the cubic-shaped scaffolds with a dimension of 10 10 10 mm until it reached 30 % deformation using a computer-controlled texture analyzer (CT3, Brookfield, USA) with a ramp rate of 0.5 mm s -1 [22,23]. Three identical specimens for each sample group were used in the compressive testing and average results were taken.…”

Section: Characterization Of Bone Scaffoldsmentioning

confidence: 99%

Fabrication of Bone Scaffolds from Cockle Shell Waste

2019

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Bone scaffold is a three-dimensional structure composed of materials that could enhance bone regeneration. Bone scaffolds were prepared using freeze-drying by varying the cockle shell powder concentration where sodium alginate acted as matrix. The scaffolds were then characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, texture analyzer, and liquid displacement method. The bioactivity of the scaffolds was evaluated by immersion into a simulated body fluid solution. Cockle shell powder concentrations affected the bone scaffold characteristics. The increment of the powder concentrations improved the physicochemical properties and bioactivity of the scaffolds.

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“…Carboxymethyl cellulose is an important ingredient in the preparation of biodegradable and biocompatible polymers that has applications in drug delivery and tissue engineering [16]. In addition to proper biocompatibility, the ability to make chemical changes in these molecules is an interesting range of ejaculations based on cellulose, which can be created from gel to porous sponge according to the type of application and type of crosslinking [17,18].…”

Section: Introductionmentioning

confidence: 99%

Construction and Evaluation of Composite Scaffold Properties of Cellulose Base Enhanced with Calcium Alginate Containing Propolis for Use in Skin Tissue Engineering

Asri

Asefnejad

Naeimi

2020

Journal of Asian Scientific Research

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Ideal wound dressing materials should meet the requirements including maintaining a local moist environment, good surface absorbance for wound exudate, decreasing wound surface necrosis, and avoiding the lack of moisture in the wound. Common treatments for infections caused by skin diseases, resulting in extensive damage and often cause the death of people. In this project, the electrolytic solution of carboxymethylcellulose / calcium alginate / propolis was used to fabricate suitable fiber diameter and uniform distribution. Cellulose is suitable for the grafting of a myriad of chemical groups because of the ample availability of hydroxyl groups, and Propolis was selected in this research due to its excellent properties, such as accelerating wound healing and cell growth and antibacterial growth. The optimum electrospinning conditions were achieved at a voltage of 20 kV, with a spacing of 20 cm from the syringe to the collecting plate and a rate of 15 ml / h. Then, to evaluate the properties of the scaffold. Scanning electron microscopy (SEM), infrared Fourier transform (FTIR), mean of weight loss were performed. Finally, for testing the cellular survival of the samples MTT test was performed and a mechanical test was performed on the specimens. The scaffold degradation rate was linear and resulted in its complete destruction in 21 days. Cytotoxicity testing of scaffolds yielded acceptable results. A suitable structure for porosity and permeability was obtained in calcium carboxymethylcellulose/calcium alginate/propolis scaffold and this scaffold is a good candidate for application in skin tissue engineering. Contribution/ Originality: In this project, the electrolytic solution of carboxymethylcellulose / calcium alginate / propolis was used to fabricate suitable fiber diameter and uniform distribution.

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Spontaneous patterning and nanoparticle encapsulation in carboxymethylcellulose/alginate/dextran hydrogels and sponges

Cited by 24 publications

References 20 publications

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Fabrication of Bone Scaffolds from Cockle Shell Waste

Construction and Evaluation of Composite Scaffold Properties of Cellulose Base Enhanced with Calcium Alginate Containing Propolis for Use in Skin Tissue Engineering

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